Research library - Signaling/Regulation

This library is a growing collection of the most significant research advances and key review articles, categorized by subject areas, from across the literature.

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2012

• 12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

  Uderhardt S., Herrmann M., Oskolkova O., Aschermann S., Bicker W. et al.

  Immunity (Published online 1 April 2012)

  [doi: 10.1016/j.immuni.2012.03.010]

• Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger?

  Jensen-Urstad A. and Semenkovich C.

  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821, (2012)

  [doi: 10.1016/j.bbalip.2011.09.017]

• Hypoxia causes triglyceride accumulation via HIF-1-mediated stimulation of lipin 1 expression

  Mylonis I., Sembongi H., Befani C., Liakos P., Siniossoglou S. et al.

  Journal of Cell Science (Published online 30 March 2012)

  [doi: 10.1242/jcs.106682]

• Ataxin-1 poly-Q-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1

  Calandria J., Mukherjee P., de Rivero J., Zhu M., Petasis N. et al.

  Journal of Biological Chemistry (Published online 16 April 2012)

  [doi: 10.1074/jbc.M111.287078]

• Sphingosine 1-Phosphate (S1P) Regulates Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells

  Stanford J., Morris A., Sunkara M., Popa G., Larson K. et al.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.M111.268185]

• Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts

  Liu S., Li Y., Kim S., Fu Q., Parikh D. et al.

  Proceedings of the National Academy of Sciences (Published online 9 April 2012)

  [doi: 10.1073/pnas.1117862109]

• Phospholipase D and mTORC1: Nutrients Are What Bring Them Together

  Wiczer B.M. and Thomas G.

  Science Signaling 5, pe13 (2012)

  [doi: 10.1126/scisignal.2003019]

• Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages

  Valdearcos M., Esquinas E., Meana C., Pena L., Gil-De L. et al.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.M112.342915]

• Piceatannol, Natural Polyphenolic Stilbene, Inhibits Adipogenesis via Modulation of Mitotic Clonal Expansion and Insulin Receptor-dependent Insulin Signaling in Early Phase of Differentiation

  Kwon J., Seo S., Heo Y., Yue S., Cheng J. et al.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.M111.259721]

• A Detour for Yeast Oxysterol Binding Proteins

  Beh C., McMaster C., Kozminski K. and Menon A.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.R111.338400]

• Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

  Eguchi K., Manabe I., Oishi-Tanaka Y., Ohsugi M., Kono N. et al.

  Cell Metabolism (Published online 1 April 2012)

  [doi: 10.1016/j.cmet.2012.01.023]

• Two PI 3-Kinases and One PI 3-Phosphatase Together Establish the Cyclic Waves of Phagosomal PtdIns(3)P Critical for the Degradation of Apoptotic Cells

  Lu N., Shen Q., Mahoney T., Neukomm L., Wang Y. et al.

  PLoS Biology (Published online 17 January 2012)

  [doi: 10.1371/journal.pbio.1001245]

• Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

  Zhang C., Wendel A., Keogh M., Harris T., Chen J. et al.

  Proceedings of the National Academy of Sciences 109, (2012)

  [doi: 10.1073/pnas.1110730109]

• Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

  Bozinovski S., Uddin M., Vlahos R., Thompson M., McQualter J. et al.

  Proceedings of the National Academy of Sciences 109, (2012)

  [doi: 10.1073/pnas.1109382109]

• The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

  van Gils J., Derby M., Fernandes L., Ramkhelawon B., Ray T. et al.

  Nat Immunol (Published online 8 January 2012)

  [doi: 10.1038/ni.2205]

• Signal-dependent Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate without Activation of Phospholipase C

  Lev S., Katz B., Tzarfaty V. and Minke B.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.M111.266585]

• Star-PAP Control of BIK Expression and Apoptosis Is Regulated by Nuclear PIPKIα and PKCδ Signaling

  Li W., Laishram R., Ji Z., Barlow C., Tian B. et al.

  Molecular Cell 45, (2012)

  [doi: 10.1016/j.molcel.2011.11.017]

• Oxysterols are allosteric activators of the oncoprotein Smoothened

  Nachtergaele S., Mydock L., Krishnan K., Rammohan J., Schlesinger P. et al.

  Nat Chem Biol (Published online 8 January 2012)

  [doi: 10.1038/nchembio.765]

• Structure of HDAC3 bound to co-repressor and inositol tetraphosphate

  Watson P., Fairall L., Santos G. and Schwabe J.

  Nature (Published online 9 January 2012)

  [doi: 10.1038/nature10728]

• Regulation of maternal phospholipid composition and IP3-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans

  Kniazeva M., Shen H., Euler T., Wang C. and Han M.

  Genes & Development 26, (2012)

  [doi: 10.1101/gad.187054.112]

• Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion

  Mondal S., Subramanian K., Sakai J., Bajrami B. and Luo H.

  Molecular Biology of the Cell (Published online 1 April 2012)

  [doi: 10.1091/mbc.E11-10-0889]

• Lysophosphatidylinositol signalling: New wine from an old bottle

  Pineiro R. and Falasca M.

  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821, (2012)

  [doi: 10.1016/j.bbalip.2012.01.009]

• Lymphopenia induced by a novel selective S1P1 antagonist structurally unrelated to S1P

  Fujii Y., Ohtake H., Ono N., Hara T., Sakurai T. et al.

  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821, (2012)

  [doi: 10.1016/j.bbalip.2011.12.006]

• Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism

  Albers J., Vuletic S. and Cheung M.

  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821, (2012)

  [doi: 10.1016/j.bbalip.2011.06.013]

• The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

  Fukuhara S., Simmons S., Kawamura S., Inoue A., Orba Y. et al.

  The Journal of Clinical Investigation (Published online 2 April 2012)

  [doi: 10.1172/JCI60746]

• Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor

  Pucci M., Pasquariello N., Battista N., di Tommaso M., Rapino C. et al.

  Journal of Biological Chemistry (Published online 19 March 2012)

  [doi: 10.1074/jbc.M111.314880]

• Sphingoid Bases and the Serine Catabolic Enzyme CHA1 Define a Novel Feedforward/Feedback Mechanism in the Response to Serine Availability

  Montefusco D., Newcomb B., Gandy J., Brice S., Matmati N. et al.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.M111.313445]

• Exploring the World of Phospholipids and Their Interactions with Proteins: The Work of William Dowhan

  Simoni R. and Mukhopadhyay R.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.O112.000002]

• The cellular and signaling networks linking the immune system and metabolism in disease

  Osborn O. and Olefsky J.

  Nat Med 18, 363 - 374 (2012)

  [doi: 10.1038/nm.2627]

• Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

  Calkin A. and Tontonoz P.

  Nat Rev Mol Cell Biol (Published online 14 March 2012)

  [doi: 10.1038/nrm3312]

• A role for the NLRP3 inflammasome in metabolic diseases - did Warburg miss inflammation?

  Wen H., Ting J.P. and O'Neill L.

  Nat Immunol 13, 352 - 357 (2012)

  [doi: 10.1038/ni.2228]

• Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis

  Oyoshi M., He R., Kanaoka Y., Elkhal A., Kawamoto S. et al.

  Proceedings of the National Academy of Sciences (Published online 27 March 2012)

  [doi: 10.1073/pnas.1203127109]

• Connections between Sphingosine Kinase and Phospholipase D in the Abscisic Acid Signaling Pathway in Arabidopsis

  Guo L., Mishra G., Markham J., Li M., Tawfall A. et al.

  The Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.M111.274274]

• FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

  Zechner R., Zimmermann R., Eichmann T., Kohlwein S., Haemmerle G. et al.

  Cell Metabolism 15, (2012)

  [doi: 10.1016/j.cmet.2011.12.018]

• Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

  Antonucci F., Turola E., Riganti L., Caleo M., Gabrielli M. et al.

  EMBO J 31, 1231 - 1240 (2012)

  [doi: 10.1038/emboj.2011.489]

• Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2 Production in Astrocytes

  Font-Nieves M., Sans-Fons M., Gorina R., Bonfill-Teixidor E., Salas-Perdomo A. et al.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.M111.327874]

• Membrane Estrogen Signaling Enhances Tumorigenesis and Metastatic Potential of Breast Cancer Cells via Estrogen Receptor-α36 (ERα36)

  Chaudhri R., Olivares-Navarrete R., Cuenca N., Hadadi A., Boyan B. et al.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.M111.292946]

• Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

  Chipuk J., McStay G., Bharti A., Kuwana T., Clarke C. et al.

  Cell 148, (2012)

  [doi: 10.1016/j.cell.2012.01.038]

• Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP

  Sample V., DiPilato L., Yang J., Ni Q., Saucerman J. et al.

  Nat Chem Biol (Published online 26 February 2012)

  [doi: 10.1038/nchembio.799]

• Vitamin E decreases bone mass by stimulating osteoclast fusion

  Fujita K., Iwasaki M., Ochi H., Fukuda T., Ma C. et al.

  Nat Med (Published online 4 March 2012)

  [doi: 10.1038/nm.2659]

• Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D

  Moreau K., Ravikumar B., Puri C. and Rubinsztein D.

  The Journal of Cell Biology 196, (2012)

  [doi: 10.1083/jcb.201110114]

• PI3K signalling: the path to discovery and understanding

  Vanhaesebroeck B., Stephens L. and Hawkins P.

  Nat Rev Mol Cell Biol 13, 195 - 203 (2012)

  [doi: 10.1038/nrm3290]

• A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing

  Mousley C., Yuan P., Gaur N., Trettin K., Nile A. et al.

  Cell 148, (2012)

  [doi: 10.1016/j.cell.2011.12.026]

• An intrinsically labile [alpha]-helix abutting the BCL9-binding site of [beta]-catenin is required for its inhibition by carnosic acid

  de la Roche M., Rutherford T., Gupta D., Veprintsev D., Saxty B. et al.

  Nat Commun 3, 680 (2012)

  [doi: 10.1038/ncomms1680]

• Triggering Actin Comets Versus Membrane Ruffles: Distinctive Effects of Phosphoinositides on Actin Reorganization

  Ueno T., Falkenburger B.H., Pohlmeyer C. and Inoue T.

  Science Signaling 4, ra87 (2011)

  [doi: 10.1126/scisignal.2002033]

• Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2

  Mahankali M., Peng H., Henkels K., Dinauer M. and Gomez-Cambronero J.

  Proceedings of the National Academy of Sciences 108, (2011)

  [doi: 10.1073/pnas.1114692108]

• Emerging roles for retinoids in regeneration and differentiation in normal and disease states

  Gudas L.

  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821, (2012)

  [doi: 10.1016/j.bbalip.2011.08.002]

• Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis

  Berrya D. and Noy N.

  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821, (2012)

  [doi: 10.1016/j.bbalip.2011.07.002]

• Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme

  Lamour N., Wijesinghe D., Mietla J., Ward K., Stahelin R. et al.

  Journal of Biological Chemistry 286, (2011)

  [doi: 10.1074/jbc.M111.310169]

• WNK1 Promotes PIP2 Synthesis to Coordinate Growth Factor and GPCR-Gq Signaling

  An S., Cha S., Yoon J., Chang S., Ross E. et al.

  Current Biology 21, (2011)

  [doi: 10.1016/j.cub.2011.11.002]

• Choline metabolism in malignant transformation

  Glunde K., Bhujwalla Z. and Ronen S.

  Nat Rev Cancer 11, 835 - 848 (2011)

  [doi: 10.1038/nrc3162]

• Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

  Metallo C., Gameiro P., Bell E., Mattaini K., Yang J. et al.

  Nature (Published online 20 November 2011)

  [doi: 10.1038/nature10602]

• Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

  Nieto-Posadas A., Picazo-Juárez G., Llorente I., Jara-Oseguera A., Morales-Lázaro S. et al.

  Nat Chem Biol (Published online 20 November 2011)

  [doi: 10.1038/nchembio.712]

• Phosphatidylserine Binding Is Essential for Plasma Membrane Recruitment and Signaling Function of 3-Phosphoinositide-dependent Kinase-1

  Lucas N. and Cho W.

  Journal of Biological Chemistry 286, (2011)

  [doi: 10.1074/jbc.M111.300806]

• A Glycosphingolipid/Caveolin-1 Signaling Complex Inhibits Motility of Human Ovarian Carcinoma Cells

  Prinetti A., Cao T., Illuzzi G., Prioni S., Aureli M. et al.

  Journal of Biological Chemistry 286, (2011)

  [doi: 10.1074/jbc.M111.286146]

• Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer

  Muthusamy S., Andersson S., Kim H., Butler R., Waage L. et al.

  Proceedings of the National Academy of Sciences of the United States of America 108, (2011)

  [doi: 10.1073/pnas.1117772108]

• A Highly Dynamic ER-Derived Phosphatidylinositol-Synthesizing Organelle Supplies Phosphoinositides to Cellular Membranes

  Kim Y., Guzman-Hernandez M. and Balla T.

  Developmental Cell 21, (2011)

  [doi: 10.1016/j.devcel.2011.09.005]

• Phosphoinositide Function in Cytokinesis

  Brill J., Wong R. and Wilde A.

  Current Biology 21, (2011)

  [doi: 10.1016/j.cub.2011.10.001]

• Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis

  Legate K., Takahashi S., Bonakdar N., Fabry B., Boettiger D. et al.

  EMBO J (Published online 16 September 2011)

  [doi: 10.1038/emboj.2011.332]

• Mammalian erythroblast enucleation requires PI3K-dependent cell polarization

  Wang J., Ramirez T., Ji P., Jayapal S., Lodish H. et al.

  Journal of Cell Science (Published online 15 January 2012)

  [doi: 10.1242/jcs.088286]

• Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

  Kebede M., Ferdaoussi M., Mancini A., Alquier T., Kulkarni R. et al.

  Proceedings of the National Academy of Sciences 109, (2012)

  [doi: 10.1073/pnas.1114350109]

• Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes

  Irino Y., Tokuda E., Hasegawa J., Itoh T. and Takenawa T.

  Journal of Lipid Research (Published online 1 April 2012)

  [doi: 10.1194/jlr.D019547]

• Suppression of adipose lipolysis by long-chain fatty Acid analogs

  Kalderon B., Azazmeh N., Azulay N., Vissler N., Valitsky M. et al.

  Journal of Lipid Research (Published online 1 May 2012)

  [doi: 10.1194/jlr.M022673]

• VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium

  Karnezis T., Shayan R., Caesar C., Roufail S., Harris N. et al.

  Cancer Cell 21, (2012)

  [doi: 10.1016/j.ccr.2011.12.026]

• Phospholipase C[gamma]-2 and Intracellular Calcium Are Required for Lipopolysaccharide-induced Toll-like Receptor 4 (TLR4) Endocytosis and Interferon Regulatory Factor 3 (IRF3) Activation

  Chiang C., Veckman V., Limmer K. and David M.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.C111.328559]

• Up-regulation of ATP Binding Cassette Transporter A1 Expression by Very Low Density Lipoprotein Receptor and Apolipoprotein E Receptor 2

  Chen X., Guo Z., Okoro E., Zhang H., Zhou L. et al.

  Journal of Biological Chemistry 287, (2012)

  [doi: 10.1074/jbc.M111.310888]

• Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression

  Lucki N., Bandyopadhyay S., Wang E., Merrill A. and Sewer M.

  Molecular Endocrinology 26, (2012)

  [doi: 10.1210/me.2011-1150] LIPID MAPS

• The GDI-like solubilizing factor PDE[delta] sustains the spatial organization and signalling of Ras family proteins

  Chandra A., Grecco H., Pisupati V., Perera D., Cassidy L. et al.

  Nat Cell Biol 14, 148 - 158 (2012)

  [doi: 10.1038/ncb2394]

• Phosphoinositide Signaling Regulates the Exocyst Complex and Polarized Integrin Trafficking in Directionally Migrating Cells

  Thapa N., Sun Y., Schramp M., Choi S., Ling K. et al.

  Developmental Cell 22, (2012)

  [doi: 10.1016/j.devcel.2011.10.030]

• Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

  Park S., Ahmad F., Philp A., Baar K., Williams T. et al.

  Cell 148, (2012)

  [doi: 10.1016/j.cell.2012.01.017]

• Myosin I Links PIP3 Signaling to Remodeling of the Actin Cytoskeleton in Chemotaxis

  Chen C., Wang Y., Sesaki H. and Iijima M.

  Science Signaling 5, (2012)

  [doi: 10.1126/scisignal.2002446]

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