Microarray data for Cyp51: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Cyp51
KLA  ATP  ATP+KLA
 cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA 1.05 1.08 1.11 .93 .82 .50 .52
 ATP 1.01 1.07 1.27 1.22 .98 .75 1.09
 ATP+KLA 1.06 1.10 1.09 1.03 .72 .44 .39

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Cyp51
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] 25OHC/Ctl (?) .95 .95 .65 .29 .27 .25 .24
 25-OHC*/* (?) .99 .92 .67 .17 .08 .08 .09
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Cyp51
KLA  Compactin  Compactin+KLA
 cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA 1.00 1.25 1.15 1.23 .91 .64 .59
 Compactin .97 1.02 1.08 1.09 1.04 1.11 1.04
 Compactin+KLA .95 1.16 1.30 1.46 1.14 .71 .71

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Cyp51
KLA  Compactin  Compactin+KLA
 cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA 1.08 1.27 1.30 .81 .89 .84 .73
 Compactin 1.08 1.03 1.13 1.13 1.11 1.16 .92
 Compactin+KLA 1.12 1.18 1.56 .94 .78 .83 .89