Microarray data for Dhcr7: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Dhcr7
KLA  ATP  ATP+KLA
 7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] KLA .58 .54 .52 .49 .39 .47 .71
 ATP 1.01 1.09 1.17 1.19 .71 .39 .74
 ATP+KLA .58 .56 .58 .64 .47 .45 .32

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Dhcr7
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] 25OHC/Ctl (?) 1.01 .91 .93 .67 .59 .59 .45
 25-OHC*/* (?) .98 .93 .77 .42 .32 .29 .26
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Dhcr7
KLA  Compactin  Compactin+KLA
 7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] KLA .96 .91 .78 .37 .26 .33 .57
 Compactin 1.05 1.02 1.07 1.07 1.02 1.08 1.08
 Compactin+KLA .96 .94 .76 .39 .29 .42 .65

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Dhcr7
KLA  Compactin  Compactin+KLA
 7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] KLA 1.11 1.08 .83 .44 .67 1.00 1.16
 Compactin 1.25 1.16 1.17 1.45 1.20 .98 1.00
 Compactin+KLA 1.26 1.02 .84 .49 .71 1.01 1.21