Microarray data for Ptgs1: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Ptgs1
KLA  ATP  ATP+KLA
 prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA [NM_008969] KLA .74 .74 .76 .74 .61 .53 .18
 ATP 1.01 1.05 1.29 1.14 .99 1.16 3.96
 ATP+KLA .77 .71 .88 .77 .75 .61 .40

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Ptgs1
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA [NM_008969] 25OHC/Ctl (?) 1.06 1.01 .96 .89 .64 .57 .74
 25-OHC*/* (?) .89 1.12 .94 1.02 .64 .56 .68
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Ptgs1
KLA  Compactin  Compactin+KLA
 prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA [NM_008969] KLA 1.02 .96 .96 .56 .34 .27 .28
 Compactin 1.03 .96 1.13 1.05 .99 1.05 .86
 Compactin+KLA 1.01 .93 .88 .59 .36 .35 .30

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Ptgs1
KLA  Compactin  Compactin+KLA
 prostaglandin-endoperoxide synthase 1 (Ptgs1), mRNA [NM_008969] KLA .94 1.11 1.04 .87 .97 .92 .97
 Compactin .85 1.06 1.14 1.02 1.11 1.28 2.13
 Compactin+KLA .95 1.02 1.03 1.01 .90 .99 1.05