Microarray data for Ptgs2: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Ptgs2
KLA  ATP  ATP+KLA
 prostaglandin-endoperoxide synthase 2 (Ptgs2), mRNA [NM_011198] KLA 181.04 220.88 218.58 132.79 103.05 22.69 18.02
 ATP 2.47 9.45 52.13 208.62 271.22 306.11 6.86
 ATP+KLA 233.39 387.29 617.86 1069.32 608.44 290.80 112.22

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Ptgs2
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
prostaglandin-endoperoxide synthase 2 (Ptgs2), mRNA [NM_011198] 25OHC/Ctl (?) .98 1.02 .89 .98 .95 1.05 1.25
 25-OHC*/* (?) 1.08 .97 .98 .78 .82 .96 1.06
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Ptgs2
KLA  Compactin  Compactin+KLA
 prostaglandin-endoperoxide synthase 2 (Ptgs2), mRNA [NM_011198] KLA 1.64 10.05 13.19 27.94 17.76 7.95 5.98
 Compactin 1.07 1.01 1.08 1.13 1.13 1.16 1.20
 Compactin+KLA 1.44 10.54 15.24 27.67 14.52 5.60 3.78

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Ptgs2
KLA  Compactin  Compactin+KLA
 prostaglandin-endoperoxide synthase 2 (Ptgs2), mRNA [NM_011198] KLA 1.71 5.67 12.17 46.29 77.95 86.42 105.26
 Compactin .78 .87 1.03 .83 .90 .97 2.25
 Compactin+KLA 1.55 5.50 11.35 45.69 81.04 135.77 153.55