Microarray data for Sc4mol: fold-change ratios

Bone marrow-derived macrophage cells treated with Kdo2-Lipid A (KLA) and ATP

Gene Time course graph Description Treatment 15min 30min 1h 2h 4h 8h 20h
Sc4mol
KLA  ATP  ATP+KLA
 sterol-C4-methyl oxidase-like (Sc4mol), mRNA [NM_025436] KLA .43 .37 .41 .44 .44 .41 .54
 ATP .95 .92 1.30 .92 .70 .47 1.36
 ATP+KLA .41 .37 .45 .38 .35 .23 .37

Bone marrow-derived macrophage cells treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sc4mol
25OHC/Ctl - treatment with 25-OHC / no treatment
25-OHC*/* - lipid depleted media containing compactin and treatment with 25-OHC / lipid depleted media containing compactin only
sterol-C4-methyl oxidase-like (Sc4mol), mRNA [NM_025436] 25OHC/Ctl (?) 1.01 .90 .70 .49 .42 .35 .37
 25-OHC*/* (?) .89 .90 .60 .29 .20 .19 .19
 
 

Thioglycolate-elicited macrophage cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sc4mol
KLA  Compactin  Compactin+KLA
 sterol-C4-methyl oxidase-like (Sc4mol), mRNA [NM_025436] KLA 1.01 .90 .67 .59 .59 .44 .47
 Compactin .99 .91 1.04 1.08 1.06 1.05 1.09
 Compactin+KLA 1.00 .85 .80 .67 .79 .54 .58

RAW 264.7 cells treated with Kdo2-Lipid A (KLA) and compactin

Gene Time course graph Description Treatment 30min 1h 2h 4h 8h 12h 24h
Sc4mol
KLA  Compactin  Compactin+KLA
 sterol-C4-methyl oxidase-like (Sc4mol), mRNA [NM_025436] KLA .95 1.13 1.08 .60 .90 1.07 .94
 Compactin .89 .92 .90 .92 .89 1.07 1.28
 Compactin+KLA .98 .95 1.10 .78 1.00 1.18 1.30