Gene/Proteome Database (LMPD)

LMPD ID
LMP000225
Gene ID
20288
Species
Mus musculus (Mouse)
Gene Name
macrophage scavenger receptor 1
Gene Symbol
Msr1
Synonyms
MRS-A; MSR; MSR-A; SR-AI; SR-AII; Scara1; Scvr
Alternate Names
macrophage scavenger receptor types I and II; SR-A; scavenger receptor type A; macrophage acetylated LDL receptor I and II
Chromosome
8
Map Location
8 A4|8 23.89 cM

Proteins

macrophage scavenger receptor types I and II isoform a
Refseq ID NP_112472
Protein GI 85861254
UniProt ID Q8CED7
mRNA ID NM_031195
Length 354
RefSeq Status VALIDATED
MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSRSV
macrophage scavenger receptor types I and II isoform b
Refseq ID NP_001106797
Protein GI 164664520
UniProt ID P30204
mRNA ID NM_001113326
Length 458
RefSeq Status VALIDATED
MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS

Gene Information

Entrez Gene ID
20288
Gene Name
macrophage scavenger receptor 1
Gene Symbol
Msr1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005581 IEA:UniProtKB-KW C collagen trimer
GO:0031410 IEA:Ensembl C cytoplasmic vesicle
GO:0005829 IEA:Ensembl C cytosol
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034362 IEA:UniProtKB-KW C low-density lipoprotein particle
GO:0005886 TAS:Reactome C plasma membrane
GO:0030169 IMP:BHF-UCL F low-density lipoprotein particle binding
GO:0005044 IEA:InterPro F scavenger receptor activity
GO:0030301 IMP:BHF-UCL P cholesterol transport
GO:0042953 IMP:MGI P lipoprotein transport
GO:0034381 IMP:BHF-UCL P plasma lipoprotein particle clearance
GO:0010886 IMP:BHF-UCL P positive regulation of cholesterol storage
GO:0010744 IGI:BHF-UCL P positive regulation of macrophage derived foam cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
ko04145 Phagosome
mmu04145 Phagosome

REACTOME Pathway Links

REACTOME Pathway ID Description
5894073 Binding and Uptake of Ligands by Scavenger Receptors
5894076 Scavenging by Class A Receptors

Domain Information

InterPro Annotations

Accession Description
IPR008160 Collagen triple helix repeat
IPR003543 Macrophage scavenger receptor
IPR001190 SRCR domain
IPR017448 SRCR-like domain

UniProt Annotations

Entry Information

Gene Name
macrophage scavenger receptor 1
Protein Entry
Q8CED7_MOUSE
UniProt ID
Q8CED7
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=I; IsoId=P30204-1; Sequence=Displayed; Name=II; IsoId=P30204-2; Sequence=VSP_006231, VSP_006232;
Function Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).
Sequence Caution Sequence=AAA39747.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA39748.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Contains 1 SRCR domain. {ECO:0000255|PROSITE- ProRule:PRU00196}.
Similarity Contains 1 collagen-like domain. {ECO:0000305}.
Subcellular Location Membrane; Single-pass type II membrane protein.
Subunit Homotrimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP000225 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
85861254 RefSeq NP_112472 354 macrophage scavenger receptor types I and II isoform a
164664520 RefSeq NP_001106797 458 macrophage scavenger receptor types I and II isoform b

Identical Sequences to LMP000225 proteins

Reference Database Accession Length Protein Name
GI:85861254 DBBJ BAC25973.1 354 unnamed protein product [Mus musculus]
GI:85861254 DBBJ BAE30370.1 354 unnamed protein product [Mus musculus]
GI:85861254 DBBJ BAE30744.1 354 unnamed protein product [Mus musculus]
GI:85861254 DBBJ BAE33337.1 354 unnamed protein product [Mus musculus]
GI:85861254 DBBJ BAE29630.1 354 unnamed protein product [Mus musculus]
GI:164664520 SwissProt P30204.3 458 RecName: Full=Macrophage scavenger receptor types I and II; AltName: Full=Macrophage acetylated LDL receptor I and II; AltName: Full=Scavenger receptor type A; Short=SR-A; AltName: CD_antigen=CD204 [Mus musculus]

Related Sequences to LMP000225 proteins

Reference Database Accession Length Protein Name
GI:85861254 DBBJ BAE32842.1 354 unnamed protein product [Mus musculus]
GI:164664520 GenBank AAA39747.1 454 macrophage scavenger receptor type I [Mus musculus]
GI:85861254 GenBank AAF14001.1 458 scavenger receptor type A SR-A [Mus musculus]
GI:164664520 GenBank AAF14001.1 458 scavenger receptor type A SR-A [Mus musculus]
GI:85861254 GenBank EDL35489.1 354 macrophage scavenger receptor 1 [Mus musculus]
GI:85861254 RefSeq NP_001106797.1 458 macrophage scavenger receptor types I and II isoform b [Mus musculus]
GI:164664520 RefSeq NP_001178868.1 454 macrophage scavenger receptor types I and II [Rattus norvegicus]
GI:164664520 RefSeq XP_006253268.1 509 PREDICTED: macrophage scavenger receptor types I and II isoform X1 [Rattus norvegicus]
GI:85861254 RefSeq XP_006509374.1 481 PREDICTED: macrophage scavenger receptor types I and II isoform X1 [Mus musculus]
GI:164664520 RefSeq XP_006509374.1 481 PREDICTED: macrophage scavenger receptor types I and II isoform X1 [Mus musculus]
GI:164664520 RefSeq XP_006509375.1 454 PREDICTED: macrophage scavenger receptor types I and II isoform X2 [Mus musculus]
GI:85861254 SwissProt P30204.3 458 RecName: Full=Macrophage scavenger receptor types I and II; AltName: Full=Macrophage acetylated LDL receptor I and II; AltName: Full=Scavenger receptor type A; Short=SR-A; AltName: CD_antigen=CD204 [Mus musculus]