Gene/Proteome Database (LMPD)

LMPD ID
LMP000363
Gene ID
14571
Species
Mus musculus (Mouse)
Gene Name
glycerol phosphate dehydrogenase 2, mitochondrial
Gene Symbol
Gpd2
Synonyms
AA408484; AI448216; AU021455; AW494132; GPDH; Gdm1; Gpd-m; Gpdh-m; TISP38
Alternate Names
glycerol-3-phosphate dehydrogenase, mitochondrial; FAD-linked glycerol-3-phosphate dehydrogenase; glycerol phosphate dehydrogenase 1, mitochondrial; glycerol-3-phosphate dehydrogenase 2, mitochondrial
Chromosome
2
Map Location
2 C1.1|2 31.66 cM
EC Number
1.1.5.3

Proteins

glycerol-3-phosphate dehydrogenase, mitochondrial precursor
Refseq ID NP_034404
Protein GI 224922803
UniProt ID Q64521
mRNA ID NM_010274
Length 727
RefSeq Status VALIDATED
MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEAAGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL
transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 4420 peptide sequence: MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEA mat_peptide: 43..727 product: Glycerol-3-phosphate dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 76552 peptide sequence: AGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 4420 peptide sequence: MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEA mat_peptide: 43..727 product: Glycerol-3-phosphate dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 76552 peptide sequence: AGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL
glycerol-3-phosphate dehydrogenase, mitochondrial precursor
Refseq ID NP_034404
Protein GI 224922803
UniProt ID Q64521
mRNA ID NM_010274
Length 727
RefSeq Status VALIDATED
MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEAAGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL
transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 4420 peptide sequence: MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEA mat_peptide: 43..727 product: Glycerol-3-phosphate dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 76552 peptide sequence: AGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL transit_peptide: 1..42 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 4420 peptide sequence: MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEA mat_peptide: 43..727 product: Glycerol-3-phosphate dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64521.2) calculated_mol_wt: 76552 peptide sequence: AGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL
glycerol-3-phosphate dehydrogenase, mitochondrial precursor
Refseq ID NP_001139292
Protein GI 224922806
UniProt ID Q64521
mRNA ID NM_001145820
Length 727
RefSeq Status VALIDATED
Protein sequence is identical to GI:224922803 (mRNA isoform)
glycerol-3-phosphate dehydrogenase, mitochondrial precursor
Refseq ID NP_001139292
Protein GI 224922806
UniProt ID Q64521
mRNA ID NM_001145820
Length 727
RefSeq Status VALIDATED
Protein sequence is identical to GI:224922803 (mRNA isoform)

Gene Information

Entrez Gene ID
14571
Gene Name
glycerol phosphate dehydrogenase 2, mitochondrial
Gene Symbol
Gpd2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009331 TAS:MGI C glycerol-3-phosphate dehydrogenase complex
GO:0005743 IDA:MGI C mitochondrial inner membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0005509 IEA:InterPro F calcium ion binding
GO:0052591 IEA:UniProtKB-EC F sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
GO:0043010 IGI:MGI P camera-type eye development
GO:0006094 IMP:MGI P gluconeogenesis
GO:0019563 IEA:UniProtKB-UniPathway P glycerol catabolic process
GO:0006072 IMP:MGI P glycerol-3-phosphate metabolic process
GO:0035264 IGI:MGI P multicellular organism growth

KEGG Pathway Links

KEGG Pathway ID Description
mmu00564 Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
AERESPDON-PWY aerobic respiration -- electron donors reaction list
PWY-6118 glycerol-3-phosphate shuttle

Domain Information

InterPro Annotations

Accession Description
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR006076 FAD dependent oxidoreductase
IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase

UniProt Annotations

Entry Information

Gene Name
glycerol phosphate dehydrogenase 2, mitochondrial
Protein Entry
GPDM_MOUSE
UniProt ID
Q64521
Species
Mouse

Comments

Comment Type Description
Catalytic Activity sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Enzyme Regulation Calcium-binding enhance the activity of the enzyme.
Pathway Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.
Similarity Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}.
Similarity Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular Location Mitochondrion inner membrane.

Identical and Related Proteins

Unique RefSeq proteins for LMP000363 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
224922803 RefSeq NP_034404 727 glycerol-3-phosphate dehydrogenase, mitochondrial precursor
224922803 RefSeq NP_034404 727 glycerol-3-phosphate dehydrogenase, mitochondrial precursor
224922803 RefSeq NP_034404 727 glycerol-3-phosphate dehydrogenase, mitochondrial precursor
224922803 RefSeq NP_034404 727 glycerol-3-phosphate dehydrogenase, mitochondrial precursor

Identical Sequences to LMP000363 proteins

Reference Database Accession Length Protein Name
GI:224922803 DBBJ BAE39294.1 727 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAE39294.1 727 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAE39294.1 727 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAE39294.1 727 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAE26028.1 727 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAE26028.1 727 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAE26028.1 727 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAE26028.1 727 unnamed protein product [Mus musculus]
GI:224922803 RefSeq NP_001139292.1 727 glycerol-3-phosphate dehydrogenase, mitochondrial precursor [Mus musculus]
GI:224922803 RefSeq NP_001139292.1 727 glycerol-3-phosphate dehydrogenase, mitochondrial precursor [Mus musculus]
GI:224922803 RefSeq NP_001139292.1 727 glycerol-3-phosphate dehydrogenase, mitochondrial precursor [Mus musculus]
GI:224922803 RefSeq NP_001139292.1 727 glycerol-3-phosphate dehydrogenase, mitochondrial precursor [Mus musculus]
GI:224922803 SwissProt Q64521.2 727 RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; AltName: Full=Protein TISP38; Flags: Precursor [Mus musculus]
GI:224922803 SwissProt Q64521.2 727 RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; AltName: Full=Protein TISP38; Flags: Precursor [Mus musculus]
GI:224922803 SwissProt Q64521.2 727 RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; AltName: Full=Protein TISP38; Flags: Precursor [Mus musculus]
GI:224922803 SwissProt Q64521.2 727 RecName: Full=Glycerol-3-phosphate dehydrogenase, mitochondrial; Short=GPD-M; Short=GPDH-M; AltName: Full=Protein TISP38; Flags: Precursor [Mus musculus]

Related Sequences to LMP000363 proteins

Reference Database Accession Length Protein Name
GI:224922803 DBBJ BAA08926.1 727 glycerol-3-phosphate dehydrogenase [Mus musculus]
GI:224922803 DBBJ BAA08926.1 727 glycerol-3-phosphate dehydrogenase [Mus musculus]
GI:224922803 DBBJ BAA08926.1 727 glycerol-3-phosphate dehydrogenase [Mus musculus]
GI:224922803 DBBJ BAA08926.1 727 glycerol-3-phosphate dehydrogenase [Mus musculus]
GI:224922803 DBBJ BAC28685.1 726 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAC28685.1 726 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAC28685.1 726 unnamed protein product [Mus musculus]
GI:224922803 DBBJ BAC28685.1 726 unnamed protein product [Mus musculus]
GI:224922803 GenBank AAB50545.1 727 FAD-linked glycerol-3-phosphate dehydrogenase [Mus musculus]
GI:224922803 GenBank AAB50545.1 727 FAD-linked glycerol-3-phosphate dehydrogenase [Mus musculus]
GI:224922803 GenBank AAB50545.1 727 FAD-linked glycerol-3-phosphate dehydrogenase [Mus musculus]
GI:224922803 GenBank AAB50545.1 727 FAD-linked glycerol-3-phosphate dehydrogenase [Mus musculus]
GI:224922803 GenBank AAH21359.1 727 Glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus]
GI:224922803 GenBank AAH21359.1 727 Glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus]
GI:224922803 GenBank AAH21359.1 727 Glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus]
GI:224922803 GenBank AAH21359.1 727 Glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus]
GI:224922803 GenBank EDL26931.1 727 glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus]
GI:224922803 GenBank EDL26931.1 727 glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus]
GI:224922803 GenBank EDL26931.1 727 glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus]
GI:224922803 GenBank EDL26931.1 727 glycerol phosphate dehydrogenase 2, mitochondrial [Mus musculus]
GI:224922803 GenBank ADT54649.1 727 Sequence 127 from patent US 7842783
GI:224922803 GenBank ADT54649.1 727 Sequence 127 from patent US 7842783
GI:224922803 GenBank ADT54649.1 727 Sequence 127 from patent US 7842783
GI:224922803 GenBank ADT54649.1 727 Sequence 127 from patent US 7842783