Gene/Proteome Database (LMPD)

LMPD ID
LMP000546
Gene ID
66002
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 4, subfamily F, polypeptide 12
Gene Symbol
CYP4F12
Synonyms
CYPIVF12; F22329_1
Alternate Names
cytochrome P450 4F12; cytochrome P450, subfamily IVF, polypeptide 12
Chromosome
19
Map Location
19p13.1
EC Number
1.14.14.1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Orthologs
View orthologs and multiple alignments for CYP4F12

Proteins

cytochrome P450 4F12
Refseq ID NP_076433
Protein GI 333033782
UniProt ID Q9HCS2
mRNA ID NM_023944
Length 524
RefSeq Status REVIEWED
MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ

Gene Information

Entrez Gene ID
66002
Gene Name
cytochrome P450, family 4, subfamily F, polypeptide 12
Gene Symbol
CYP4F12
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016324 ISS:UniProtKB C apical plasma membrane
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043231 ISS:UniProtKB C intracellular membrane-bounded organelle
GO:0018685 ISS:UniProtKB F alkane 1-monooxygenase activity
GO:0008392 ISS:UniProtKB F arachidonic acid epoxygenase activity
GO:0070330 IEA:UniProtKB-EC F aromatase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0050051 ISS:UniProtKB F leukotriene-B4 20-monooxygenase activity
GO:0047057 ISS:UniProtKB F vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0019369 ISS:UniProtKB P arachidonic acid metabolic process
GO:0017144 ISS:UniProtKB P drug metabolic process
GO:0019373 ISS:UniProtKB P epoxygenase P450 pathway
GO:0036101 ISS:UniProtKB P leukotriene B4 catabolic process
GO:0001676 ISS:UniProtKB P long-chain fatty acid metabolic process
GO:0030195 ISS:UniProtKB P negative regulation of blood coagulation
GO:0055114 ISS:UniProtKB P oxidation-reduction process
GO:0003095 ISS:UniProtKB P pressure natriuresis
GO:0003091 ISS:UniProtKB P renal water homeostasis
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0055078 ISS:UniProtKB P sodium ion homeostasis
GO:0000038 ISS:UniProtKB P very long-chain fatty acid metabolic process
GO:0042360 ISS:UniProtKB P vitamin E metabolic process
GO:0042371 ISS:UniProtKB P vitamin K biosynthetic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_13645 Eicosanoids
REACT_13814 Fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 4, subfamily F, polypeptide 12
Protein Entry
CP4FC_HUMAN
UniProt ID
Q9HCS2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HCS2-1; Sequence=Displayed; Name=2; IsoId=Q9HCS2-2; Sequence=VSP_055581, VSP_055582; Note=No experimental confirmation available.;
Catalytic Activity RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
Cofactor Name=heme; Xref=ChEBI
Function Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.
Sequence Caution Sequence=EAW84492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane {ECO
Tissue Specificity Expressed in small intestine, liver, colon and heart.

Identical and Related Proteins

Unique RefSeq proteins for LMP000546 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
333033782 RefSeq NP_076433 524 cytochrome P450 4F12

Identical Sequences to LMP000546 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP000546 proteins

Reference Database Accession Length Protein Name
GI:333033782 GenBank ACJ99920.1 524 Sequence 204 from patent US 7425605
GI:333033782 GenBank ACK02577.1 524 Sequence 54 from patent US 7427664
GI:333033782 GenBank ACK02841.1 524 Sequence 204 from patent US 7427667
GI:333033782 GenBank ACK09331.1 524 Sequence 54 from patent US 7435798
GI:333033782 GenBank ACK17105.1 524 Sequence 54 from patent US 7442765
GI:333033782 SwissProt Q9HCS2.2 524 RecName: Full=Cytochrome P450 4F12; AltName: Full=CYPIVF12 [Homo sapiens]