Gene/Proteome Database (LMPD)

LMPD ID
LMP000599
Gene ID
9420
Species
Homo sapiens (Human)
Gene Name
cytochrome P450, family 7, subfamily B, polypeptide 1
Gene Symbol
CYP7B1
Synonyms
CBAS3; CP7B; SPG5A
Alternate Names
25-hydroxycholesterol 7-alpha-hydroxylase; cytochrome P450 7B1; oxysterol 7alpha-hydroxylase; oxysterol 7-alpha-hydroxylase; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1
Chromosome
8
Map Location
8q21.3
EC Number
1.14.13.100
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for CYP7B1

Proteins

25-hydroxycholesterol 7-alpha-hydroxylase
Refseq ID NP_004811
Protein GI 4758104
UniProt ID O75881
mRNA ID NM_004820
Length 506
RefSeq Status REVIEWED
MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEIKQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRYKVKS

Gene Information

Entrez Gene ID
9420
Gene Name
cytochrome P450, family 7, subfamily B, polypeptide 1
Gene Symbol
CYP7B1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0033783 IEA:UniProtKB-EC F 25-hydroxycholesterol 7alpha-hydroxylase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008396 TAS:ProtInc F oxysterol 7-alpha-hydroxylase activity
GO:0006699 TAS:Reactome P bile acid biosynthetic process
GO:0008206 TAS:Reactome P bile acid metabolic process
GO:0008219 IEA:UniProtKB-KW P cell death
GO:0008203 IEA:UniProtKB-KW P cholesterol metabolic process
GO:0033147 IEA:Ensembl P negative regulation of intracellular estrogen receptor signaling pathway
GO:0050679 IEA:Ensembl P positive regulation of epithelial cell proliferation
GO:0060740 IEA:Ensembl P prostate gland epithelium morphogenesis
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0016125 TAS:Reactome P sterol metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00120 Primary bile acid biosynthesis
hsa00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_11048 Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 7, subfamily B, polypeptide 1
Protein Entry
CP7B1_HUMAN
UniProt ID
O75881
Species
Human

Comments

Comment Type Description
Catalytic Activity (25R)-cholest-5-ene-3-beta,26-diol + NADPH + O(2) = (25R)-cholest-5-ene-3-beta,7-alpha,26-triol + NADP(+) + H(2)O.
Catalytic Activity Cholest-5-ene-3-beta,25-diol + NADPH + O(2) = cholest-5-ene-3-beta,7-alpha,25-triol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI
Disease Congenital bile acid synthesis defect 3 (CBAS3) [MIM
Disease Spastic paraplegia 5A, autosomal recessive (SPG5A) [MIM
Pathway Lipid metabolism; bile acid biosynthesis.
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CYP7B1ID40255ch8q21.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP000599 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4758104 RefSeq NP_004811 506 25-hydroxycholesterol 7-alpha-hydroxylase

Identical Sequences to LMP000599 proteins

Reference Database Accession Length Protein Name
GI:4758104 GenBank AAD20021.1 506 oxysterol 7alpha-hydroxylase [Homo sapiens]
GI:4758104 GenBank AAK11850.1 506 oxysterol 7alpha-hydroxylase [Homo sapiens]
GI:4758104 GenBank EAW86877.1 506 cytochrome P450, family 7, subfamily B, polypeptide 1 [Homo sapiens]
GI:4758104 GenBank AAI36575.1 506 Cytochrome P450, family 7, subfamily B, polypeptide 1 [Homo sapiens]
GI:4758104 GenBank AIC50352.1 506 CYP7B1, partial [synthetic construct]
GI:4758104 SwissProt O75881.2 506 RecName: Full=25-hydroxycholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 7B1; AltName: Full=Oxysterol 7-alpha-hydroxylase [Homo sapiens]

Related Sequences to LMP000599 proteins

Reference Database Accession Length Protein Name
GI:4758104 GenBank AAC95426.1 506 oxysterol 7alpha-hydroxylase [Homo sapiens]
GI:4758104 GenBank JAA10317.1 506 cytochrome P450, family 7, subfamily B, polypeptide 1 [Pan troglodytes]
GI:4758104 GenBank JAA28189.1 506 cytochrome P450, family 7, subfamily B, polypeptide 1 [Pan troglodytes]
GI:4758104 RefSeq XP_001159731.1 506 PREDICTED: 25-hydroxycholesterol 7-alpha-hydroxylase [Pan troglodytes]
GI:4758104 RefSeq XP_003268400.1 506 PREDICTED: 25-hydroxycholesterol 7-alpha-hydroxylase-like [Nomascus leucogenys]
GI:4758104 RefSeq XP_003831426.1 506 PREDICTED: 25-hydroxycholesterol 7-alpha-hydroxylase [Pan paniscus]