Gene/Proteome Database (LMPD)

LMPD ID
LMP001485
Gene ID
5875
Species
Homo sapiens (Human)
Gene Name
Rab geranylgeranyltransferase, alpha subunit
Gene Symbol
RABGGTA
Synonyms
PTAR3
Alternate Names
geranylgeranyl transferase type-2 subunit alpha; Rab GGTase alpha; Rab GG transferase alpha; rab geranyl-geranyltransferase subunit alpha; geranylgeranyl transferase type II subunit alpha; protein prenyltransferase alpha subunit repeat containing 3
Chromosome
14
Map Location
14q11.2
EC Number
2.5.1.60

Proteins

geranylgeranyl transferase type-2 subunit alpha
Refseq ID NP_878256
Protein GI 33469951
UniProt ID Q92696
mRNA ID NM_182836
Length 567
RefSeq Status VALIDATED
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT
geranylgeranyl transferase type-2 subunit alpha
Refseq ID NP_004572
Protein GI 53828918
UniProt ID Q92696
mRNA ID NM_004581
Length 567
RefSeq Status VALIDATED
Protein sequence is identical to GI:33469951 (mRNA isoform)

Gene Information

Entrez Gene ID
5875
Gene Name
Rab geranylgeranyltransferase, alpha subunit
Gene Symbol
RABGGTA
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005968 ISS:UniProtKB C Rab-protein geranylgeranyltransferase complex
GO:0017137 ISS:UniProtKB F Rab GTPase binding
GO:0004663 ISS:UniProtKB F Rab geranylgeranyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006464 TAS:ProtInc P cellular protein modification process
GO:0018344 ISS:UniProtKB P protein geranylgeranylation
GO:0007601 TAS:ProtInc P visual perception

Domain Information

InterPro Annotations

Accession Description
IPR001611 Leucine-rich repeat
IPR002088 Protein prenyltransferase, alpha subunit
IPR009087 Rab geranylgeranyltransferase, alpha subunit, insert-domain

UniProt Annotations

Entry Information

Gene Name
Rab geranylgeranyltransferase, alpha subunit
Protein Entry
PGTA_HUMAN
UniProt ID
Q92696
Species
Human

Comments

Comment Type Description
Catalytic Activity Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Enzyme Regulation The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.
Function Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Similarity Belongs to the protein prenyltransferase subunit alpha family.
Similarity Contains 5 LRR (leucine-rich) repeats.
Similarity Contains 6 PFTA repeats. {ECO
Subunit Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM

Identical and Related Proteins

Unique RefSeq proteins for LMP001485 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
33469951 RefSeq NP_878256 567 geranylgeranyl transferase type-2 subunit alpha

Identical Sequences to LMP001485 proteins

Reference Database Accession Length Protein Name
GI:33469951 GenBank AAH03093.1 567 Rab geranylgeranyltransferase, alpha subunit [Homo sapiens]
GI:33469951 GenBank AAV21105.1 567 Sequence 1365 from patent US 6753314
GI:33469951 GenBank EAW66044.1 567 Rab geranylgeranyltransferase, alpha subunit, isoform CRA_d [Homo sapiens]
GI:33469951 GenBank EAW66045.1 567 Rab geranylgeranyltransferase, alpha subunit, isoform CRA_d [Homo sapiens]
GI:33469951 GenBank AIC49556.1 567 RABGGTA, partial [synthetic construct]
GI:33469951 RefSeq NP_004572.3 567 geranylgeranyl transferase type-2 subunit alpha [Homo sapiens]

Related Sequences to LMP001485 proteins

Reference Database Accession Length Protein Name
GI:33469951 DBBJ BAF84036.1 567 unnamed protein product [Homo sapiens]
GI:33469951 DBBJ BAF85302.1 567 unnamed protein product [Homo sapiens]
GI:33469951 EMBL CAG46596.1 567 RABGGTA, partial [Homo sapiens]
GI:33469951 GenBank JAA06777.1 567 Rab geranylgeranyltransferase, alpha subunit [Pan troglodytes]
GI:33469951 GenBank JAA06778.1 567 Rab geranylgeranyltransferase, alpha subunit [Pan troglodytes]
GI:33469951 GenBank JAA11829.1 567 Rab geranylgeranyltransferase, alpha subunit [Pan troglodytes]