Gene/Proteome Database (LMPD)

LMPD ID
LMP001517
Gene ID
3710
Species
Homo sapiens (Human)
Gene Name
inositol 1,4,5-trisphosphate receptor, type 3
Gene Symbol
ITPR3
Synonyms
IP3R; IP3R3
Chromosome
6
Map Location
6p21
Summary
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
Orthologs
View orthologs and multiple alignments for ITPR3

Proteins

inositol 1,4,5-trisphosphate receptor type 3
Refseq ID NP_002215
Protein GI 153945846
UniProt ID Q59ES2
mRNA ID NM_002224
Length 2671
RefSeq Status REVIEWED
MSEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDKNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFANTMEFVEDYLNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPAMLQAYEDPGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKFEENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSTTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSGKGEEVEAGAAKDKKERPTDEEGFLHPPGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFSSPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDAHISSMLSSGASCAAAAQRNASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSRGDLPDPIGTGLDPDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRYSLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLFWILICFSIAALFTKRYSIRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGLSVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLNSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFVDVQNCISR

Gene Information

Entrez Gene ID
3710
Gene Name
inositol 1,4,5-trisphosphate receptor, type 3
Gene Symbol
ITPR3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:Ensembl C endoplasmic reticulum membrane
GO:0005730 IEA:Ensembl C nucleolus
GO:0005654 IEA:Ensembl C nucleoplasm
GO:0005220 IEA:Ensembl F inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005218 IEA:Ensembl F intracellular ligand-gated calcium channel activity
GO:0035091 IEA:Ensembl F phosphatidylinositol binding
GO:0060402 IEA:Ensembl P calcium ion transport into cytosol
GO:0060291 IEA:Ensembl P long-term synaptic potentiation
GO:0007613 IEA:Ensembl P memory
GO:0050913 IEA:Ensembl P sensory perception of bitter taste
GO:0050916 IEA:Ensembl P sensory perception of sweet taste
GO:0050917 IEA:Ensembl P sensory perception of umami taste

KEGG Pathway Links

KEGG Pathway ID Description
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04921 Oxytocin signaling pathway
hsa04611 Platelet activation
hsa04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093 MIR_motif
IPR000699 RIH (RyR and IP3R Homology) domain
IPR015925 Ryanodine receptor-related

UniProt Annotations

Entry Information

Gene Name
inositol 1,4,5-trisphosphate receptor, type 3
Protein Entry
ITPR3_HUMAN
UniProt ID
Q59ES2
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001517 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
153945846 RefSeq NP_002215 2671 inositol 1,4,5-trisphosphate receptor type 3

Identical Sequences to LMP001517 proteins

Reference Database Accession Length Protein Name
GI:153945846 EMBL CBX47635.1 2671 unnamed protein product [Homo sapiens]
GI:153945846 GenBank ADA20758.1 2671 Sequence 2582 from patent US 7608413
GI:153945846 GenBank ADS31078.1 2671 Sequence 1610 from patent US 7781168
GI:153945846 GenBank ADT51810.1 2671 Sequence 3827 from patent US 7842467
GI:153945846 GenBank AEN36654.1 2671 Sequence 2582 from patent US 7998689
GI:153945846 GenBank AHL57949.1 2671 Sequence 430 from patent US 8647822

Related Sequences to LMP001517 proteins

Reference Database Accession Length Protein Name
GI:153945846 DBBJ BAA05385.1 2671 type 3 inositol 1,4,5-trisphosphate receptor [Homo sapiens]
GI:153945846 GenBank ADA20759.1 2671 Sequence 2583 from patent US 7608413
GI:153945846 GenBank ADT51811.1 2671 Sequence 3828 from patent US 7842467
GI:153945846 GenBank AEN36655.1 2671 Sequence 2583 from patent US 7998689
GI:153945846 GenBank AEQ43228.1 2671 Sequence 6 from patent US 8034553
GI:153945846 GenBank AHD78032.1 2671 Sequence 25011 from patent US 8586006