Gene/Proteome Database (LMPD)
LMPD ID
LMP002300
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyl-CoA dehydrogenase family, member 11
Gene Symbol
Synonyms
ACAD-11
Alternate Names
acyl-CoA dehydrogenase family member 11; 62113 protein; acyl-Coenzyme A dehydrogenase family, member 11
Chromosome
3
Map Location
3q22.1
EC Number
1.3.99.-
Proteins
| acyl-CoA dehydrogenase family member 11 | |
|---|---|
| Refseq ID | NP_115545 |
| Protein GI | 38505218 |
| UniProt ID | Q709F0 |
| mRNA ID | NM_032169 |
| Length | 780 |
| RefSeq Status | VALIDATED |
| MKPGATGESDLAEVLPQHKFDSKSLEAYLNQHLSGFGAEREATLTIAQYRAGKSNPTFYLQKGFQTYVLRKKPPGSLLPKAHQIDREFKVQKALFSIGFPVPKPILYCSDTSVIGTEFYVMEHVQGRIFRDLTIPGLSPAERSAIYVATVETLAQLHSLNIQSLQLEGYGIGAGYCKRQVSTWTKQYQAAAHQDIPAMQQLSEWLMKNLPDNDNEENLIHGDFRLDNIVFHPKECRVIAVLDWELSTIGHPLSDLAHFSLFYFWPRTVPMINQGSYSENSGIPSMEELISIYCRCRGINSILPNWNFFLALSYFKMAGIAQGVYSRYLLGNNSSEDSFLFANIVQPLAETGLQLSKRTFSTVLPQIDTTGQLFVQTRKGQEVLIKVKHFMKQHILPAEKEVTEFYVQNENSVDKWGKPLVIDKLKEMAKVEGLWNLFLPAVSGLSHVDYALIAEETGKCFFAPDVFNCQAPDTGNMEVLHLYGSEEQKKQWLEPLLQGNITSCFCMTEPDVASSDATNIECSIQRDEDSYVINGKKWWSSGAGNPKCKIAIVLGRTQNTSLSRHKQHSMILVPMNTPGVKIIRPLSVFGYTDNFHGGHFEIHFNQVRVPATNLILGEGRGFEISQGRLGPGRIHHCMRTVGLAERALQIMCERATQRIAFKKKLYAHEVVAHWIAESRIAIEKIRLLTLKAAHSMDTLGSAGAKKEIAMIKVAAPRAVSKIVDWAIQVCGGAGVSQDYPLANMYAITRVLRLADGPDEVHLSAIATMELRDQAKRLTAKI | |
Gene Information
Entrez Gene ID
Gene Name
acyl-CoA dehydrogenase family, member 11
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031966 | IDA:UniProtKB | C | mitochondrial membrane |
| GO:0005634 | IDA:UniProtKB | C | nucleus |
| GO:0005777 | ISS:HGNC | C | peroxisome |
| GO:0050660 | IEA:InterPro | F | flavin adenine dinucleotide binding |
| GO:0004466 | IDA:UniProtKB | F | long-chain-acyl-CoA dehydrogenase activity |
| GO:0070991 | IDA:UniProtKB | F | medium-chain-acyl-CoA dehydrogenase activity |
| GO:0016772 | IEA:InterPro | F | transferase activity, transferring phosphorus-containing groups |
| GO:0017099 | IDA:UniProtKB | F | very-long-chain-acyl-CoA dehydrogenase activity |
| GO:0033539 | IDA:UniProtKB | P | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR009075 | Acyl-CoA dehydrogenase/oxidase C-terminal |
| IPR013786 | Acyl-CoA dehydrogenase/oxidase, N-terminal |
| IPR009100 | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain |
| IPR006091 | Acyl-CoA oxidase/dehydrogenase, central domain |
| IPR002575 | Aminoglycoside phosphotransferase |
| IPR011009 | Protein kinase-like domain |
UniProt Annotations
Entry Information
Gene Name
acyl-CoA dehydrogenase family, member 11
Protein Entry
ACD11_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q709F0-1; Sequence=Displayed; Name=2; IsoId=Q709F0-2; Sequence=VSP_021188; Name=3; IsoId=Q709F0-3; Sequence=VSP_021187; |
| Catalytic Activity | Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
| Cofactor | Name=FAD; Xref=ChEBI |
| Function | Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. |
| Sequence Caution | Sequence=BAB14158.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; |
| Similarity | Belongs to the acyl-CoA dehydrogenase family. |
| Subcellular Location | Peroxisome . Mitochondrion . Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316. |
| Subunit | Homodimer. |
| Tissue Specificity | Widely expressed with highest levels in brain followed by liver, heart and kidney. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002300 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 38505218 | RefSeq | NP_115545 | 780 | acyl-CoA dehydrogenase family member 11 |
Identical Sequences to LMP002300 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:38505218 | EMBL | CAE75546.1 | 780 | 62113 protein [Homo sapiens] |
| GI:38505218 | EMBL | CBX51385.1 | 780 | unnamed protein product [Homo sapiens] |
| GI:38505218 | GenBank | AAI25205.1 | 780 | Acyl-Coenzyme A dehydrogenase family, member 11 [Homo sapiens] |
| GI:38505218 | GenBank | ACN05213.1 | 780 | Sequence 54 from patent US 7485308 |
| GI:38505218 | GenBank | ACQ18681.1 | 780 | Sequence 595 from patent US 7510850 |
| GI:38505218 | GenBank | AIC52519.1 | 780 | ACAD11, partial [synthetic construct] |
Related Sequences to LMP002300 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:38505218 | EMBL | CAE55233.1 | 780 | putative acyl-CoA dehydrogenase [Homo sapiens] |
| GI:38505218 | GenBank | JAA30921.1 | 780 | acyl-CoA dehydrogenase family, member 11 [Pan troglodytes] |
| GI:38505218 | GenBank | JAA30922.1 | 780 | acyl-CoA dehydrogenase family, member 11 [Pan troglodytes] |
| GI:38505218 | RefSeq | XP_004036367.1 | 780 | PREDICTED: acyl-CoA dehydrogenase family member 11 [Gorilla gorilla gorilla] |
| GI:38505218 | RefSeq | XP_008974352.1 | 780 | PREDICTED: acyl-CoA dehydrogenase family member 11 isoform X1 [Pan paniscus] |
| GI:38505218 | SwissProt | Q709F0.2 | 780 | RecName: Full=Acyl-CoA dehydrogenase family member 11; Short=ACAD-11 [Homo sapiens] |