Gene/Proteome Database (LMPD)

LMPD ID
LMP002385
Gene ID
80724
Species
Homo sapiens (Human)
Gene Name
acyl-CoA dehydrogenase family, member 10
Gene Symbol
ACAD10
Synonyms
-
Alternate Names
acyl-CoA dehydrogenase family member 10; ACAD-10; acyl-Coenzyme A dehydrogenase family, member 10
Chromosome
12
Map Location
12q24.12
EC Number
1.3.99.-
Summary
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
Orthologs
View orthologs and multiple alignments for ACAD10

Proteins

acyl-CoA dehydrogenase family member 10 isoform a
Refseq ID NP_001130010
Protein GI 211971008
UniProt ID Q6JQN1
mRNA ID NM_001136538
Length 1090
RefSeq Status REVIEWED
MCVRSCFQSPRLQWVWRTAFLKHTQRRHQGSHRWTHLGGSTYRAVIFDMGGVLIPSPGRVAAEWEVQNRIPSGTILKALMEGGENGPWMRFMRAEITAEGFLREFGRLCSEMLKTSVPVDSFFSLLTSERVAKQFPVMTEAITQIRAKGLQTAVLSNNFYLPNQKSFLPLDRKQFDVIVESCMEGICKPDPRIYKLCLEQLGLQPSESIFLDDLGTNLKEAARLGIHTIKRQGFAVLPKLVSNSWAQAIYPPYPPKVVRLQVNDPETAVKELEALLGFTLRVGVPNTRPVKKTMEIPKDSLQKYLKDLLGIQTTGPLELLQFDHGQSNPTYYIRLANRDLVLRKKPPGTLLPSAHAIEREFRIMKALANAGVPVPNVLDLCEDSSVIGTPFYVMEYCPGLIYKDPSLPGLEPSHRRAIYTAMNTVLCKIHSVDLQAVGLEDYGKQGDYIPRQVRTWVKQYRASETSTIPAMERLIEWLPLHLPRQQRTTVVHGDFRLDNLVFHPEEPEVLAVLDWELSTLGDPLADVAYSCLAHYLPSSFPVLRGINDCDLTQLGIPAAEEYFRMYCLQMGLPPTENWNFYMAFSFFRVAAILQGVYKRSLTGQASSTYAEQTGKLTEFVSNLAWDFAVKEGFRVFKEMPFTNPLTRSYHTWARPQSQWCPTGSRSYSSVPEASPAHTSRGGLVISPESLSPPVRELYHRLKHFMEQRVYPAEPELQSHQASAARWSPSPLIEDLKEKAKAEGLWNLFLPLEADPEKKYGAGLTNVEYAHLCELMGTSLYAPEVCNCSAPDTGNMELLVRYGTEAQKARWLIPLLEGKARSCFAMTEPQVASSDATNIEASIREEDSFYVINGHKWWITGILDPRCQLCVFMGKTDPHAPRHRQQSVLLVPMDTPGIKIIRPLTVYGLEDAPGGHGEVRFEHVRVPKENMVLGPGRGFEIAQGRLGPGRIHHCMRLIGFSERALALMKARVKSRLAFGKPLVEQGTVLADIAQSRVEIEQARLLVLRAAHLMDLAGNKAAALDIAMIKMVAPSMASRVIDRAIQAFGAAGLSSDYPLAQFFTWARALRFADGPDEVHRATVAKLELKHRI
acyl-CoA dehydrogenase family member 10 isoform b
Refseq ID NP_079523
Protein GI 48976061
UniProt ID Q6JQN1
mRNA ID NM_025247
Length 1059
RefSeq Status REVIEWED
MCVRSCFQSPRLQWVWRTAFLKHTQRRHQGSHRWTHLGGSTYRAVIFDMGGVLIPSPGRVAAEWEVQNRIPSGTILKALMEGGENGPWMRFMRAEITAEGFLREFGRLCSEMLKTSVPVDSFFSLLTSERVAKQFPVMTEAITQIRAKGLQTAVLSNNFYLPNQKSFLPLDRKQFDVIVESCMEGICKPDPRIYKLCLEQLGLQPSESIFLDDLGTNLKEAARLGIHTIKVNDPETAVKELEALLGFTLRVGVPNTRPVKKTMEIPKDSLQKYLKDLLGIQTTGPLELLQFDHGQSNPTYYIRLANRDLVLRKKPPGTLLPSAHAIEREFRIMKALANAGVPVPNVLDLCEDSSVIGTPFYVMEYCPGLIYKDPSLPGLEPSHRRAIYTAMNTVLCKIHSVDLQAVGLEDYGKQGDYIPRQVRTWVKQYRASETSTIPAMERLIEWLPLHLPRQQRTTVVHGDFRLDNLVFHPEEPEVLAVLDWELSTLGDPLADVAYSCLAHYLPSSFPVLRGINDCDLTQLGIPAAEEYFRMYCLQMGLPPTENWNFYMAFSFFRVAAILQGVYKRSLTGQASSTYAEQTGKLTEFVSNLAWDFAVKEGFRVFKEMPFTNPLTRSYHTWARPQSQWCPTGSRSYSSVPEASPAHTSRGGLVISPESLSPPVRELYHRLKHFMEQRVYPAEPELQSHQASAARWSPSPLIEDLKEKAKAEGLWNLFLPLEADPEKKYGAGLTNVEYAHLCELMGTSLYAPEVCNCSAPDTGNMELLVRYGTEAQKARWLIPLLEGKARSCFAMTEPQVASSDATNIEASIREEDSFYVINGHKWWITGILDPRCQLCVFMGKTDPHAPRHRQQSVLLVPMDTPGIKIIRPLTVYGLEDAPGGHGEVRFEHVRVPKENMVLGPGRGFEIAQGRLGPGRIHHCMRLIGFSERALALMKARVKSRLAFGKPLVEQGTVLADIAQSRVEIEQARLLVLRAAHLMDLAGNKAAALDIAMIKMVAPSMASRVIDRAIQAFGAAGLSSDYPLAQFFTWARALRFADGPDEVHRATVAKLELKHRI

Gene Information

Entrez Gene ID
80724
Gene Name
acyl-CoA dehydrogenase family, member 10
Gene Symbol
ACAD10
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 NAS:UniProtKB C mitochondrion
GO:0003995 IEA:InterPro F acyl-CoA dehydrogenase activity
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0016787 IEA:InterPro F hydrolase activity
GO:0016772 IEA:InterPro F transferase activity, transferring phosphorus-containing groups

Domain Information

InterPro Annotations

Accession Description
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR002575 Aminoglycoside phosphotransferase
IPR006439 HAD hydrolase, subfamily IA
IPR023214 HAD-like domain
IPR023198 Phosphoglycolate phosphatase, domain 2
IPR011945 Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
acyl-CoA dehydrogenase family, member 10
Protein Entry
ACD10_HUMAN
UniProt ID
Q6JQN1
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6JQN1-1; Sequence=Displayed; Name=2; IsoId=Q6JQN1-2; Sequence=VSP_024634, VSP_024635; Name=3; IsoId=Q6JQN1-3; Sequence=VSP_024630, VSP_024633, VSP_024634, VSP_024635; Note=No experimental confirmation available.; Name=4; IsoId=Q6JQN1-4; Sequence=VSP_024631, VSP_024632; Note=No experimental confirmation available.; Name=5; IsoId=Q6JQN1-5; Sequence=VSP_044980; Note=No experimental confirmation available.;
Catalytic Activity Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
Cofactor Name=FAD; Xref=ChEBI
Function Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA.
Sequence Caution Sequence=AAH15056.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the acyl-CoA dehydrogenase family.
Tissue Specificity Widely expressed with highest expression in fetal brain, followed by heart, muscle, kidney and adult brain. Expression levels varying from isoform to isoform.

Identical and Related Proteins

Unique RefSeq proteins for LMP002385 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
211971008 RefSeq NP_001130010 1090 acyl-CoA dehydrogenase family member 10 isoform a
48976061 RefSeq NP_079523 1059 acyl-CoA dehydrogenase family member 10 isoform b

Identical Sequences to LMP002385 proteins

Reference Database Accession Length Protein Name
GI:48976061 GenBank AAQ88260.1 1059 ACAD 10 [Homo sapiens]
GI:48976061 GenBank AAI26359.1 1059 Acyl-Coenzyme A dehydrogenase family, member 10 [Homo sapiens]
GI:211971008 GenBank EAW97962.1 1090 acyl-Coenzyme A dehydrogenase family, member 10, isoform CRA_b [Homo sapiens]
GI:48976061 GenBank ACW21308.1 1059 Sequence 199 from patent US 7560233
GI:48976061 GenBank AHD72045.1 1059 Sequence 7543 from patent US 8586006
GI:48976061 SwissProt Q6JQN1.1 1059 RecName: Full=Acyl-CoA dehydrogenase family member 10; Short=ACAD-10 [Homo sapiens]

Related Sequences to LMP002385 proteins

Reference Database Accession Length Protein Name
GI:211971008 GenBank AAQ88260.1 1059 ACAD 10 [Homo sapiens]
GI:211971008 GenBank AAI26359.1 1059 Acyl-Coenzyme A dehydrogenase family, member 10 [Homo sapiens]
GI:48976061 GenBank EAW97962.1 1090 acyl-Coenzyme A dehydrogenase family, member 10, isoform CRA_b [Homo sapiens]
GI:211971008 GenBank ACW21308.1 1059 Sequence 199 from patent US 7560233
GI:48976061 GenBank JAA06565.1 1059 acyl-CoA dehydrogenase family, member 10 [Pan troglodytes]
GI:48976061 GenBank JAA18488.1 1060 acyl-CoA dehydrogenase family, member 10 [Pan troglodytes]
GI:48976061 GenBank JAA39588.1 1059 acyl-CoA dehydrogenase family, member 10 [Pan troglodytes]
GI:211971008 GenBank AHD72045.1 1059 Sequence 7543 from patent US 8586006
GI:211971008 RefSeq NP_079523.3 1059 acyl-CoA dehydrogenase family member 10 isoform b [Homo sapiens]
GI:48976061 RefSeq NP_001130010.1 1090 acyl-CoA dehydrogenase family member 10 isoform a [Homo sapiens]
GI:48976061 RefSeq XP_004053950.1 1059 PREDICTED: acyl-CoA dehydrogenase family member 10 [Gorilla gorilla gorilla]
GI:211971008 SwissProt Q6JQN1.1 1059 RecName: Full=Acyl-CoA dehydrogenase family member 10; Short=ACAD-10 [Homo sapiens]