Gene/Proteome Database (LMPD)

LMPD ID
LMP002456
Gene ID
74114
Species
Mus musculus (Mouse)
Gene Name
carnitine O-octanoyltransferase
Gene Symbol
Crot
Synonyms
1200003H03Rik
Alternate Names
peroxisomal carnitine O-octanoyltransferase; COT
Chromosome
5
Map Location
5 A1|5
EC Number
2.3.1.137

Proteins

peroxisomal carnitine O-octanoyltransferase
Refseq ID NP_076222
Protein GI 17157983
UniProt ID Q9DC50
mRNA ID NM_023733
Length 612
RefSeq Status PROVISIONAL
MENQLTKSVEERTFQYQDSLPSLPVPALEESLKKYLESVKPFANEDEYKKTEEIVQKFQEGAGKRLHQKLLERARGKRNWLEEWWLNVAYLDVRIPSQLNVNFVGPCPHFEHYWPAREGTQLERGSMMLWHNLNYWQLLRREKLPVHKSGNTPLDMNQFRMLFSTCKVPGITRDSIMNYFKTESEGHCPTHIAVLCRGRAFVFDVLHEGCLITPPELLRQLTYIHKKCSNEPVGPSIAALTSEERTRWAKAREYLISLDPENLTLLEKIQTSLFVYSIEDSSPHATPEEYSQVFEMLLGGDPSVRWGDKSYNLISFANGIFGCCCDHAPYDAMVMVNIAHYVDERVLETEGRWKGSEKVRDIPLPEELVFTVDEKILNDVSQAKAQHLKAASDLQIAASTFTSFGKKLTKEEALHPDTFIQLALQLAYYRLHGRPGCCYETAMTRYFYHGRTETVRSCTVEAVRWCQSMQDPSASLLERQQKMLEAFAKHNKMMKDCSHGKGFDRHLLGLLLIAKEEGLPVPELFEDPLFSRSGGGGNFVLSTSLVGYLRVQGVVVPMVHNGYGFFYHIRDDRFVVACSSWRSCPETDAEKLVQMIFHAFHDMIQLMNTAHL

Gene Information

Entrez Gene ID
74114
Gene Name
carnitine O-octanoyltransferase
Gene Symbol
Crot
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0005777 IDA:MGI C peroxisome
GO:0008458 IDA:UniProtKB F carnitine O-octanoyltransferase activity
GO:0009437 IDA:UniProtKB P carnitine metabolic process
GO:0015936 IDA:UniProtKB P coenzyme A metabolic process
GO:0006635 IEA:UniProtKB-UniPathway P fatty acid beta-oxidation
GO:0006631 IDA:UniProtKB P fatty acid metabolic process
GO:0015908 IDA:MGI P fatty acid transport
GO:0006091 IEA:Ensembl P generation of precursor metabolites and energy
GO:0051791 IEA:Ensembl P medium-chain fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04146 Peroxisome
mmu04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
5893692 Beta-oxidation of pristanoyl-CoA
5892980 Peroxisomal lipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
carnitine O-octanoyltransferase
Protein Entry
OCTC_MOUSE
UniProt ID
Q9DC50
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Octanoyl-CoA + L-carnitine = CoA + L- octanoylcarnitine. {ECO:0000269|PubMed:15492013}.
Function Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. {ECO:0000269|PubMed:15492013}.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Similarity Belongs to the carnitine/choline acetyltransferase family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002456 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17157983 RefSeq NP_076222 612 peroxisomal carnitine O-octanoyltransferase

Identical Sequences to LMP002456 proteins

Reference Database Accession Length Protein Name
GI:17157983 DBBJ BAB23378.1 612 unnamed protein product [Mus musculus]
GI:17157983 GenBank AAH06593.1 612 Carnitine O-octanoyltransferase [Mus musculus]
GI:17157983 GenBank EDL14682.1 612 carnitine O-octanoyltransferase [Mus musculus]
GI:17157983 GenBank AGJ89974.1 612 peroxisomal carnitine O-octanoyltransferase, partial [synthetic construct]
GI:17157983 SwissProt Q9DC50.1 612 RecName: Full=Peroxisomal carnitine O-octanoyltransferase; Short=COT [Mus musculus]

Related Sequences to LMP002456 proteins

Reference Database Accession Length Protein Name
GI:17157983 GenBank AAH12308.1 612 Carnitine O-octanoyltransferase [Mus musculus]
GI:17157983 PDB 1XL7 612 Chain B, Crystal Structure Of Mouse Carnitine Octanoyltransferase
GI:17157983 PDB 1XMC 612 Chain A, C323m Mutant Structure Of Mouse Carnitine Octanoyltransferase
GI:17157983 PDB 1XMC 612 Chain B, C323m Mutant Structure Of Mouse Carnitine Octanoyltransferase
GI:17157983 PDB 1XMD 612 Chain A, M335v Mutant Structure Of Mouse Carnitine Octanoyltransferase
GI:17157983 PDB 1XMD 612 Chain B, M335v Mutant Structure Of Mouse Carnitine Octanoyltransferase