Gene/Proteome Database (LMPD)
Proteins
| low-density lipoprotein receptor isoform 1 precursor | |
|---|---|
| Refseq ID | NP_034830 |
| Protein GI | 113195700 |
| UniProt ID | P35951 |
| mRNA ID | NM_010700 |
| Length | 862 |
| RefSeq Status | VALIDATED |
| MSTADLMRRWVIALLLAAAGVAAEDSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCGGRVSRCIPDSWRCDGQVDCENDSDEQGCPPKTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHCQATTCGPAHFRCNSSICIPSLWACDGDVDCVDGSDEWPQNCQGRDTASKGVSSPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHCAVATCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCVNVTQCDGPNKFKCHSGECISLDKVCDSARDCQDWSDEPIKECKTNECLDNNGGCSHICKDLKIGSECLCPSGFRLVDLHRCEDIDECQEPDTCSQLCVNLEGSYKCECQAGFHMDPHTRVCKAVGSIGYLLFTNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANRLTGSDVNLVAENLLSPEDIVLFHKVTQPRGVNWCETTALLPNGGCQYLCLPAPQIGPHSPKFTCACPDGMLLAKDMRSCLTEVDTVLTTQGTSAVRPVVTASATRPPKHSEDLSAPSTPRQPVDTPGLSTVASVTVSHQVQGDMAGRGNEEQPHGMRFLSIFFPIALVALLVLGAVLLWRNWRLKNINSINFDNPVYQKTTEDELHICRSQDGYTYPSRQMVSLEDDVA | |
| sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2401 peptide sequence: MSTADLMRRWVIALLLAAAGVAA sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2330 peptide sequence: MSTADLMRRWVIALLLAAAGVA sig_peptide: 1..21 inference: non-experimental evidence, no additional details recorded note: By similarity; propagated from UniProtKB/Swiss-Prot (P35951.2) calculated_mol_wt: 2259 peptide sequence: MSTADLMRRWVIALLLAAAGV mat_peptide: 22..862 product: Low-density lipoprotein receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P35951.2) calculated_mol_wt: 92707 peptide sequence: AAEDSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCGGRVSRCIPDSWRCDGQVDCENDSDEQGCPPKTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHCQATTCGPAHFRCNSSICIPSLWACDGDVDCVDGSDEWPQNCQGRDTASKGVSSPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHCAVATCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCVNVTQCDGPNKFKCHSGECISLDKVCDSARDCQDWSDEPIKECKTNECLDNNGGCSHICKDLKIGSECLCPSGFRLVDLHRCEDIDECQEPDTCSQLCVNLEGSYKCECQAGFHMDPHTRVCKAVGSIGYLLFTNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANRLTGSDVNLVAENLLSPEDIVLFHKVTQPRGVNWCETTALLPNGGCQYLCLPAPQIGPHSPKFTCACPDGMLLAKDMRSCLTEVDTVLTTQGTSAVRPVVTASATRPPKHSEDLSAPSTPRQPVDTPGLSTVASVTVSHQVQGDMAGRGNEEQPHGMRFLSIFFPIALVALLVLGAVLLWRNWRLKNINSINFDNPVYQKTTEDELHICRSQDGYTYPSRQMVSLEDDVA | |
| low-density lipoprotein receptor isoform 2 precursor | |
|---|---|
| Refseq ID | NP_001239587 |
| Protein GI | 358030301 |
| UniProt ID | P35951 |
| mRNA ID | NM_001252658 |
| Length | 810 |
| RefSeq Status | VALIDATED |
| MSTADLMRRWVIALLLAAAGVAAEDSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCGGRVSRCIPDSWRCDGQVDCENDSDEQGCPPKTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHCQATTCGPAHFRCNSSICIPSLWACDGDVDCVDGSDEWPQNCQGRDTASKGVSSPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHCAVATCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCVNVTQCDGPNKFKCHSGECISLDKVCDSARDCQDWSDEPIKECKTNECLDNNGGCSHICKDLKIGSECLCPSGFRLVDLHRCEDIDECQEPDTCSQLCVNLEGSYKCECQAGFHMDPHTRVCKAVGSIGYLLFTNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANRLTGSDVNLVAENLLSPEDIVLFHKVTQPREVDTVLTTQGTSAVRPVVTASATRPPKHSEDLSAPSTPRQPVDTPGLSTVASVTVSHQVQGDMAGRGNEEQPHGMRFLSIFFPIALVALLVLGAVLLWRNWRLKNINSINFDNPVYQKTTEDELHICRSQDGYTYPSRQMVSLEDDVA | |
| low-density lipoprotein receptor isoform 3 presursor precursor | |
|---|---|
| Refseq ID | NP_001239588 |
| Protein GI | 358030304 |
| UniProt ID | P35951 |
| mRNA ID | NM_001252659 |
| Length | 861 |
| RefSeq Status | VALIDATED |
| MSTADLMRRWVIALLLAAAGVAEDSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCGGRVSRCIPDSWRCDGQVDCENDSDEQGCPPKTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHCQATTCGPAHFRCNSSICIPSLWACDGDVDCVDGSDEWPQNCQGRDTASKGVSSPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHCAVATCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCVNVTQCDGPNKFKCHSGECISLDKVCDSARDCQDWSDEPIKECKTNECLDNNGGCSHICKDLKIGSECLCPSGFRLVDLHRCEDIDECQEPDTCSQLCVNLEGSYKCECQAGFHMDPHTRVCKAVGSIGYLLFTNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANRLTGSDVNLVAENLLSPEDIVLFHKVTQPRGVNWCETTALLPNGGCQYLCLPAPQIGPHSPKFTCACPDGMLLAKDMRSCLTEVDTVLTTQGTSAVRPVVTASATRPPKHSEDLSAPSTPRQPVDTPGLSTVASVTVSHQVQGDMAGRGNEEQPHGMRFLSIFFPIALVALLVLGAVLLWRNWRLKNINSINFDNPVYQKTTEDELHICRSQDGYTYPSRQMVSLEDDVA | |
Gene Information
Entrez Gene ID
Gene Name
low density lipoprotein receptor
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | ISS:UniProtKB | C | Golgi apparatus |
| GO:0009986 | ISS:UniProtKB | C | cell surface |
| GO:0005905 | IEA:UniProtKB-KW | C | coated pit |
| GO:0005769 | ISS:UniProtKB | C | early endosome |
| GO:0005768 | IDA:MGI | C | endosome |
| GO:0009897 | IEA:Ensembl | C | external side of plasma membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005770 | ISS:UniProtKB | C | late endosome |
| GO:0034362 | IEA:UniProtKB-KW | C | low-density lipoprotein particle |
| GO:0005764 | ISS:UniProtKB | C | lysosome |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0043235 | ISO:MGI | C | receptor complex |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0030169 | IDA:MGI | F | low-density lipoprotein particle binding |
| GO:0005041 | IDA:MGI | F | low-density lipoprotein receptor activity |
| GO:0030229 | IDA:MGI | F | very-low-density lipoprotein particle receptor activity |
| GO:0042632 | IMP:MGI | P | cholesterol homeostasis |
| GO:0070508 | IMP:BHF-UCL | P | cholesterol import |
| GO:0008203 | IMP:MGI | P | cholesterol metabolic process |
| GO:0030301 | IMP:MGI | P | cholesterol transport |
| GO:0030299 | IEA:Ensembl | P | intestinal cholesterol absorption |
| GO:0006629 | IGI:MGI | P | lipid metabolic process |
| GO:0042159 | IDA:MGI | P | lipoprotein catabolic process |
| GO:0042157 | IGI:MGI | P | lipoprotein metabolic process |
| GO:0034383 | IMP:BHF-UCL | P | low-density lipoprotein particle clearance |
| GO:0015914 | IMP:BHF-UCL | P | phospholipid transport |
| GO:0010867 | IMP:BHF-UCL | P | positive regulation of triglyceride biosynthetic process |
| GO:0006898 | IDA:GOC | P | receptor-mediated endocytosis |
| GO:2000188 | IMP:MGI | P | regulation of cholesterol homeostasis |
| GO:0010899 | IMP:BHF-UCL | P | regulation of phosphatidylcholine catabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu04913 | Ovarian steroidogenesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR001881 | EGF-like calcium-binding domain |
| IPR018097 | EGF-like calcium-binding, conserved site |
| IPR013032 | EGF-like, conserved site |
| IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| IPR000742 | Epidermal growth factor-like domain |
| IPR009030 | Insulin-like growth factor binding protein, N-terminal |
| IPR000033 | LDLR class B repeat |
| IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
| IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| IPR011042 | Six-bladed beta-propeller, TolB-like |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | The NPXY motif mediates the interaction with the clathrin adaptor DAB2 involved in receptor internalization. {ECO:0000269|PubMed:11247302}. |
| Function | Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. |
| Ptm | Ubiquitinated by MYLIP leading to degradation. {ECO:0000250}. |
| Similarity | Belongs to the LDLR family. {ECO:0000305}. |
| Similarity | Contains 3 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}. |
| Similarity | Contains 6 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}. |
| Similarity | Contains 7 LDL-receptor class A domains. {ECO:0000255|PROSITE-ProRule:PRU00124}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Early endosome {ECO:0000250}. Late endosome {ECO:0000250}. Cell surface {ECO:0000250}. Lysosome {ECO:0000250}. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9 (By similarity). {ECO:0000250}. |
| Subunit | Interacts with LDLRAP1, ARRB1, SNX17. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts with the full length immature form of PCSK9 (via C-terminus). {ECO:0000269|PubMed:11247302, ECO:0000269|PubMed:12169628}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002476 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 113195700 | RefSeq | NP_034830 | 862 | low-density lipoprotein receptor isoform 1 precursor |
| 358030301 | RefSeq | NP_001239587 | 810 | low-density lipoprotein receptor isoform 2 precursor |
| 358030304 | RefSeq | NP_001239588 | 861 | low-density lipoprotein receptor isoform 3 presursor precursor |
Identical Sequences to LMP002476 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:113195700 | EMBL | CAA45759.1 | 862 | low density lipoprotein receptor precursor [Mus musculus] |
| GI:113195700 | GenBank | AAH53041.1 | 862 | Low density lipoprotein receptor [Mus musculus] |
| GI:113195700 | GenBank | EDL25212.1 | 862 | low density lipoprotein receptor, isoform CRA_b [Mus musculus] |
| GI:113195700 | GenBank | AEJ67035.1 | 862 | Sequence 91 from patent US 7968301 |
| GI:113195700 | GenBank | AFL31430.1 | 862 | Sequence 91 from patent US 8173125 |
| GI:113195700 | SwissProt | P35951.2 | 862 | RecName: Full=Low-density lipoprotein receptor; Short=LDL receptor; Flags: Precursor [Mus musculus] |
Related Sequences to LMP002476 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:113195700 | DBBJ | BAE30950.1 | 862 | unnamed protein product [Mus musculus] |
| GI:358030301 | DBBJ | BAE41671.1 | 810 | unnamed protein product [Mus musculus] |
| GI:113195700 | DBBJ | BAE35554.1 | 862 | unnamed protein product [Mus musculus] |
| GI:358030304 | EMBL | CAA45759.1 | 862 | low density lipoprotein receptor precursor [Mus musculus] |
| GI:358030301 | EMBL | CAA45759.1 | 862 | low density lipoprotein receptor precursor [Mus musculus] |
| GI:113195700 | GenBank | AAL23955.1 | 862 | low density lipoprotein receptor [Mus musculus] |
| GI:113195700 | GenBank | AAH19207.1 | 862 | Low density lipoprotein receptor [Mus musculus] |
| GI:358030301 | GenBank | EDL25212.1 | 862 | low density lipoprotein receptor, isoform CRA_b [Mus musculus] |
| GI:358030304 | GenBank | EDL25212.1 | 862 | low density lipoprotein receptor, isoform CRA_b [Mus musculus] |
| GI:113195700 | GenBank | AEJ67034.1 | 862 | Sequence 90 from patent US 7968301 |
| GI:358030301 | GenBank | AEJ67035.1 | 862 | Sequence 91 from patent US 7968301 |
| GI:358030304 | GenBank | AEJ67035.1 | 862 | Sequence 91 from patent US 7968301 |
| GI:113195700 | GenBank | AFL31429.1 | 862 | Sequence 90 from patent US 8173125 |
| GI:358030301 | GenBank | AFL31430.1 | 862 | Sequence 91 from patent US 8173125 |
| GI:358030304 | GenBank | AFL31430.1 | 862 | Sequence 91 from patent US 8173125 |
| GI:358030301 | RefSeq | NP_034830.2 | 862 | low-density lipoprotein receptor isoform 1 precursor [Mus musculus] |
| GI:358030304 | RefSeq | NP_034830.2 | 862 | low-density lipoprotein receptor isoform 1 precursor [Mus musculus] |
| GI:358030304 | SwissProt | P35951.2 | 862 | RecName: Full=Low-density lipoprotein receptor; Short=LDL receptor; Flags: Precursor [Mus musculus] |