Gene/Proteome Database (LMPD)

LMPD ID
LMP002591
Gene ID
17252
Species
Mus musculus (Mouse)
Gene Name
retinol dehydrogenase 11
Gene Symbol
Rdh11
Synonyms
2610319N22Rik; AI428145; AU045252; Arsdr1; C85936; CGI-82; HCBP12; M42C60; Mdt1; Psdr1; SCALD; UBE-1c1; Ube-1c
Alternate Names
retinol dehydrogenase 11; ralR1; all-trans and 9-cis; retinal reductase 1; ubiquitously expressing; short-chain aldehyde dehydrogenase; cell line MC/9.IL4-derived protein 1; short-chain dehydrogenase/reductase 1; cell line MC/9.IL4 derived transcript 1; prostate short-chain dehydrogenase/reductase 1; androgen-regulated short-chain dehydrogenase/reductase 1
Chromosome
12
Map Location
12 C3|12 35.51 cM
EC Number
1.1.1.300

Proteins

retinol dehydrogenase 11 precursor
Refseq ID NP_067532
Protein GI 19482172
UniProt ID Q9QYF1
mRNA ID NM_021557
Length 316
RefSeq Status PROVISIONAL
MFGFLLLLSLPFILYLVTPKIRKMLSSGVCTSNVQLPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQVFVRKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNLSSLGHHLGRIHFHNLQGEKFYSAGLAYCHSKLANILFTKELAKRLKGSGVTTYSVHPGTVHSELTRYSSIMRWLWQLFFVFIKTPQEGAQTSLYCALTEGLESLSGSHFSDCQLAWVSYQGRNEIIARRLWDVSCDLLGLPVDW
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2198 peptide sequence: MFGFLLLLSLPFILYLVTP

Gene Information

Entrez Gene ID
17252
Gene Name
retinol dehydrogenase 11
Gene Symbol
Rdh11
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005622 ISS:UniProtKB C intracellular
GO:0001917 IDA:MGI C photoreceptor inner segment
GO:0052650 ISO:MGI F NADP-retinol dehydrogenase activity
GO:0004745 ISS:UniProtKB F retinol dehydrogenase activity
GO:0016062 IMP:MGI P adaptation of rhodopsin mediated signaling
GO:0042574 ISO:MGI P retinal metabolic process
GO:0042572 ISS:UniProtKB P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00830 Retinol metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893902 Retinoid metabolism and transport
5892894 The canonical retinoid cycle in rods (twilight vision)

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
retinol dehydrogenase 11
Protein Entry
RDH11_MOUSE
UniProt ID
Q9QYF1
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=Q9QYF1-1; Sequence=Displayed;
Catalytic Activity All-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
Function Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent all-trans-retinal reductase. Also involved in the metabolism of short-chain aldehydes.
Ptm Not glycosylated. {ECO:0000250}.
Sequence Caution Sequence=BAA88521.1; Type=Frameshift; Positions=311; Evidence={ECO:0000305};
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Expressed at higher level in liver and testis. Expressed at lower levels in smooth muscle, thymus, submaxillary gland and epididymis. In testis, expression is restricted to pachytene spermatocytes. Also expressed in four layers of the retina, including the outer segment of rods and cones.

Identical and Related Proteins

Unique RefSeq proteins for LMP002591 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19482172 RefSeq NP_067532 316 retinol dehydrogenase 11 precursor

Identical Sequences to LMP002591 proteins

Reference Database Accession Length Protein Name
GI:19482172 DBBJ BAB23296.1 316 unnamed protein product [Mus musculus]
GI:19482172 DBBJ BAE22534.1 316 unnamed protein product [Mus musculus]
GI:19482172 GenBank AAK91516.1 316 short-chain dehydrogenase/reductase [Mus musculus]
GI:19482172 GenBank AAH18261.1 316 Retinol dehydrogenase 11 [Mus musculus]
GI:19482172 GenBank AAL79910.1 316 short-chain aldehyde dehydrogenase SCALD [Mus musculus]
GI:19482172 SwissProt Q9QYF1.2 316 RecName: Full=Retinol dehydrogenase 11; AltName: Full=Androgen-regulated short-chain dehydrogenase/reductase 1; AltName: Full=Cell line MC/9.IL4-derived protein 1; AltName: Full=M42C60; AltName: Full=Prostate short-chain dehydrogenase/reductase 1; AltName: Full=Retinal reductase 1; Short=RalR1; AltName: Full=Short-chain aldehyde dehydrogenase; Short=SCALD [Mus musculus]

Related Sequences to LMP002591 proteins

Reference Database Accession Length Protein Name
GI:19482172 DBBJ BAA82656.1 293 UBE-1a [Mus musculus]
GI:19482172 DBBJ BAA82657.1 300 UBE-1b [Mus musculus]
GI:19482172 DBBJ BAA88521.1 355 M42C60 [Mus musculus]
GI:19482172 RefSeq XP_005343318.1 316 PREDICTED: retinol dehydrogenase 11 isoform X1 [Microtus ochrogaster]
GI:19482172 RefSeq XP_006515588.1 300 PREDICTED: retinol dehydrogenase 11 isoform X1 [Mus musculus]
GI:19482172 RefSeq XP_006973172.1 316 PREDICTED: retinol dehydrogenase 11 [Peromyscus maniculatus bairdii]