Gene/Proteome Database (LMPD)
LMPD ID
LMP002865
Gene ID
Species
Homo sapiens (Human)
Gene Name
N-myristoyltransferase 2
Gene Symbol
Synonyms
-
Alternate Names
glycylpeptide N-tetradecanoyltransferase 2; NMT 2; type II N-myristoyltransferase; peptide N-myristoyltransferase 2; myristoyl-CoA:protein N-myristoyltransferase 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3
Chromosome
10
Map Location
10p13
EC Number
2.3.1.97
Summary
N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| glycylpeptide N-tetradecanoyltransferase 2 | |
|---|---|
| Refseq ID | NP_004799 |
| Protein GI | 4758816 |
| UniProt ID | O60551 |
| mRNA ID | NM_004808 |
| Length | 498 |
| RefSeq Status | REVIEWED |
| MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IDA:HPA | C | Golgi apparatus |
| GO:0005737 | IDA:HPA | C | cytoplasm |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005886 | IDA:HPA | C | plasma membrane |
| GO:0003824 | TAS:ProtInc | F | catalytic activity |
| GO:0004379 | IEA:UniProtKB-EC | F | glycylpeptide N-tetradecanoyltransferase activity |
| GO:0006499 | IEA:InterPro | P | N-terminal protein myristoylation |
| GO:0075733 | TAS:Reactome | P | intracellular transport of virus |
| GO:0007603 | TAS:Reactome | P | phototransduction, visible light |
| GO:0009249 | TAS:ProtInc | P | protein lipoylation |
| GO:0022400 | TAS:Reactome | P | regulation of rhodopsin mediated signaling pathway |
| GO:0016056 | TAS:Reactome | P | rhodopsin mediated signaling pathway |
| GO:0016032 | TAS:Reactome | P | viral process |
| GO:0019082 | TAS:Reactome | P | viral protein processing |
| GO:0019068 | TAS:Reactome | P | virion assembly |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_163919 | Inactivation, recovery and regulation of the phototransduction cascade |
| REACT_115893 | Membrane binding and targetting of GAG proteins |
| REACT_163722 | The phototransduction cascade |
| REACT_160125 | Visual phototransduction |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016181 | Acyl-CoA N-acyltransferase |
| IPR000903 | Myristoyl-CoA:protein N-myristoyltransferase |
| IPR022677 | Myristoyl-CoA:protein N-myristoyltransferase, C-terminal |
| IPR022676 | Myristoyl-CoA:protein N-myristoyltransferase, N-terminal |
| IPR022678 | Myristoyl-CoA:protein N-myristoyltransferase, conserved site |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Tetradecanoyl-CoA + glycylpeptide = CoA + N- tetradecanoylglycylpeptide. |
| Caution | Sequence AAF36406.2 was incorrectly indicated as originating from bovine. |
| Function | Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. |
| Similarity | Belongs to the NMT family. |
| Subcellular Location | Cytoplasm. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002865 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4758816 | RefSeq | NP_004799 | 498 | glycylpeptide N-tetradecanoyltransferase 2 |
Identical Sequences to LMP002865 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758816 | GenBank | JAA23156.1 | 498 | N-myristoyltransferase 2 [Pan troglodytes] |
| GI:4758816 | GenBank | JAA23157.1 | 498 | N-myristoyltransferase 2 [Pan troglodytes] |
| GI:4758816 | GenBank | JAA43126.1 | 498 | N-myristoyltransferase 2 [Pan troglodytes] |
| GI:4758816 | GenBank | JAA43128.1 | 498 | N-myristoyltransferase 2 [Pan troglodytes] |
| GI:4758816 | GenBank | JAA43129.1 | 498 | N-myristoyltransferase 2 [Pan troglodytes] |
| GI:4758816 | GenBank | AHD74333.1 | 498 | Sequence 13699 from patent US 8586006 |
Related Sequences to LMP002865 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758816 | GenBank | AAH06376.1 | 498 | N-myristoyltransferase 2 [Homo sapiens] |
| GI:4758816 | GenBank | AAP35670.1 | 498 | N-myristoyltransferase 2 [Homo sapiens] |
| GI:4758816 | GenBank | AAX29306.1 | 499 | N-myristoyltransferase 2, partial [synthetic construct] |
| GI:4758816 | GenBank | AAX32702.1 | 498 | N-myristoyltransferase 2 [synthetic construct] |
| GI:4758816 | GenBank | ABM81593.1 | 498 | N-myristoyltransferase 2 [synthetic construct] |
| GI:4758816 | GenBank | ABM84774.1 | 498 | N-myristoyltransferase 2, partial [synthetic construct] |