Gene/Proteome Database (LMPD)

LMPD ID
LMP002974
Gene ID
18719
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Gene Symbol
Pip5k1b
Synonyms
PI4P5K-I[b]; PIP5K1-beta; PIP5KIbeta; Pipk5b; STM7
Alternate Names
phosphatidylinositol 4-phosphate 5-kinase type-1 beta; ptdIns(4)P-5-kinase 1 beta; phosphatidylinositol 4-phosphate 5-kinase type I beta; phosphatidylinositol-4-phosphate 5-kinase type I beta; phosphatidylinositol-4-phosphate 5-kinase type-1 beta
Chromosome
19
Map Location
19|19 C1
EC Number
2.7.1.68

Proteins

phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Refseq ID NP_032872
Protein GI 6679329
UniProt ID P70181
mRNA ID NM_008846
Length 539
RefSeq Status VALIDATED
MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKEREKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHILDHSLKDKEEEPLQNVPDAKRPGMQKVLYSTAMESIQGPGKSADGIIAENPDTMGGIPAKSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVGEHYPHDRTTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLDLQDDASVLDVYL

Gene Information

Entrez Gene ID
18719
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Gene Symbol
Pip5k1b
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0001931 IEA:Ensembl C uropod
GO:0016308 IDA:MGI F 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0046488 IDA:MGI P phosphatidylinositol metabolic process
GO:0046854 IDA:GOC P phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu04144 Endocytosis
mmu04666 Fc gamma R-mediated phagocytosis

Domain Information

InterPro Annotations

Accession Description
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Protein Entry
PI51B_MOUSE
UniProt ID
P70181
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P70181-1; Sequence=Displayed; Name=2; IsoId=P70181-2; Sequence=VSP_016012; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=34 uM for PtdIns(4)P {ECO:0000269|PubMed:9535851}; KM=27 uM for ATP {ECO:0000269|PubMed:9535851};
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Caution There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha. {ECO:0000305}.
Enzyme Regulation Activated by phosphatidic acid. {ECO:0000269|PubMed:8798574, ECO:0000269|PubMed:9535851}.
Function Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion. {ECO:0000269|PubMed:10679324, ECO:0000269|PubMed:18772378, ECO:0000269|PubMed:8798574}.
Interaction Q9QYB1:Clic4; NbExp=4; IntAct=EBI-645167, EBI-645175;
Similarity Contains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular Location Endomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.
Subunit Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1. {ECO:0000269|PubMed:10679324, ECO:0000269|PubMed:10747863, ECO:0000269|PubMed:11032811, ECO:0000269|PubMed:15870270}.
Tissue Specificity Highly expressed in brain and testis. Barely detectable in liver and skeletal muscle. {ECO:0000269|PubMed:8798574}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002974 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6679329 RefSeq NP_032872 539 phosphatidylinositol 4-phosphate 5-kinase type-1 beta

Identical Sequences to LMP002974 proteins

Reference Database Accession Length Protein Name
GI:6679329 DBBJ BAE28830.1 539 unnamed protein product [Mus musculus]
GI:6679329 DBBJ BAE37836.1 539 unnamed protein product [Mus musculus]
GI:6679329 DBBJ BAE26901.1 539 unnamed protein product [Mus musculus]
GI:6679329 GenBank ABK42320.1 539 PI(4)P5-K alpha [synthetic construct]
GI:6679329 RefSeq XP_006526826.1 539 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [Mus musculus]
GI:6679329 SwissProt P70181.1 539 RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Short=PIP5K1-beta; Short=PtdIns(4)P-5-kinase 1 beta; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Short=PIP5KIalpha; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I beta; Short=PIP5KIbeta [Mus musculus]

Related Sequences to LMP002974 proteins

Reference Database Accession Length Protein Name
GI:6679329 GenBank AAC05374.1 539 type I alpha phosphatidylinositol-4-phosphate 5-kinase variant [Mus musculus]
GI:6679329 GenBank AAH90349.1 539 Phosphatidylinositol-4-phosphate 5-kinase, type I, beta [Rattus norvegicus]
GI:6679329 RefSeq NP_001012761.1 539 phosphatidylinositol 4-phosphate 5-kinase type-1 beta [Rattus norvegicus]
GI:6679329 RefSeq XP_006977704.1 540 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta [Peromyscus maniculatus bairdii]
GI:6679329 RefSeq XP_007627726.1 557 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [Cricetulus griseus]
GI:6679329 SwissProt Q5CZZ9.1 539 RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Short=PIP5K1-beta; Short=PtdIns(4)P-5-kinase 1 beta; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Short=PIP5KIalpha; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I beta; Short=PIP5KIbeta [Rattus norvegicus]