Gene/Proteome Database (LMPD)

LMPD ID
LMP003124
Gene ID
26876
Species
Mus musculus (Mouse)
Gene Name
alcohol dehydrogenase 4 (class II), pi polypeptide
Gene Symbol
Adh4
Synonyms
Adh2
Alternate Names
alcohol dehydrogenase 4; class II type ADH; alcohol dehydrogenase II; alcohol dehydrogenase class II
Chromosome
3
Map Location
3|3 H2
EC Number
1.1.1.1

Proteins

alcohol dehydrogenase 4
Refseq ID NP_036126
Protein GI 121247379
UniProt ID Q9QYY9
mRNA ID NM_011996
Length 377
RefSeq Status PROVISIONAL
MGTQGKVIKCKAAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINATDPKKKALFPVVLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPSSTCAVFGLGCVGLSAIIGCKIAGASRIIAIDINGEKFPKAKALGATDCLNPRELDKPVQDVITELTAGGVDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDKMTIPTVDVILGRSINGTFFGGWKSVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTILTF

Gene Information

Entrez Gene ID
26876
Gene Name
alcohol dehydrogenase 4 (class II), pi polypeptide
Gene Symbol
Adh4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0051287 IEA:Ensembl F NAD binding
GO:0003960 IDA:MGI F NADPH:quinone reductase activity
GO:0004022 IDA:MGI F alcohol dehydrogenase (NAD) activity
GO:0004024 IDA:MGI F alcohol dehydrogenase activity, zinc-dependent
GO:0004032 IDA:MGI F alditol:NADP+ 1-oxidoreductase activity
GO:0005503 IEA:Ensembl F all-trans retinal binding
GO:0019115 IEA:Ensembl F benzaldehyde dehydrogenase activity
GO:0035276 IEA:InterPro F ethanol binding
GO:0019841 IEA:Ensembl F retinol binding
GO:0004745 IEA:Ensembl F retinol dehydrogenase activity
GO:0008270 IEA:Ensembl F zinc ion binding
GO:0046164 IDA:MGI P alcohol catabolic process
GO:0006081 IDA:MGI P cellular aldehyde metabolic process
GO:0006067 IDA:MGI P ethanol metabolic process
GO:0006069 IEA:Ensembl P ethanol oxidation
GO:1901661 IDA:MGI P quinone metabolic process
GO:0042572 IEA:Ensembl P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu05204 Chemical carcinogenesis
mmu00010 Glycolysis / Gluconeogenesis

Domain Information

InterPro Annotations

Accession Description
IPR013154 Alcohol dehydrogenase GroES-like
IPR028632 Alcohol dehydrogenase family, zinc-type, class-II subfamily
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
alcohol dehydrogenase 4 (class II), pi polypeptide
Protein Entry
ADH4_MOUSE
UniProt ID
Q9QYY9
Species
Mouse

Comments

Comment Type Description
Catalytic Activity An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
Function Involved in the reduction of benzoquinones. {ECO:0000269|PubMed:10514444}.
Miscellaneous Has much lower enzymatic activity towards alcohols and aldehydes compared to human class II ADH. Strongly inhibited by omega-hydroxy fatty acids.
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Subunit Dimer. {ECO:0000269|PubMed:10970744}.
Tissue Specificity Liver specific. {ECO:0000269|PubMed:10514444}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003124 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
121247379 RefSeq NP_036126 377 alcohol dehydrogenase 4

Identical Sequences to LMP003124 proteins

Reference Database Accession Length Protein Name
GI:121247379 DBBJ BAE21459.1 377 unnamed protein product [Mus musculus]
GI:121247379 SwissProt Q9QYY9.4 377 RecName: Full=Alcohol dehydrogenase 4; AltName: Full=ADH2; AltName: Full=Alcohol dehydrogenase class II; Short=Alcohol dehydrogenase II [Mus musculus]

Related Sequences to LMP003124 proteins

Reference Database Accession Length Protein Name
GI:121247379 EMBL CAB57455.1 377 alcohol dehydrogenase II [Mus musculus]
GI:121247379 GenBank AAI00737.1 377 Alcohol dehydrogenase 4 (class II), pi polypeptide [Mus musculus]
GI:121247379 GenBank AAI00730.1 377 Alcohol dehydrogenase 4 (class II), pi polypeptide [Mus musculus]
GI:121247379 GenBank AAI00731.1 377 Alcohol dehydrogenase 4 (class II), pi polypeptide [Mus musculus]
GI:121247379 GenBank EDL12096.1 377 alcohol dehydrogenase 4 (class II), pi polypeptide [Mus musculus]
GI:121247379 PDB 1E3E 376 Chain B, Mouse Class Ii Alcohol Dehydrogenase Complex With Nadh