Gene/Proteome Database (LMPD)
LMPD ID
LMP003604
Gene ID
Species
Mus musculus (Mouse)
Gene Name
phospholipase C-like 1
Gene Symbol
Synonyms
C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL; PLDL1; PRIP; PRIP-1
Alternate Names
inactive phospholipase C-like protein 1; phospholipase C, eta 2 pseudogene; phospholipase C-related but catalytically inactive protein
Chromosome
1
Map Location
1 C1.2-C1.3|1
Proteins
| inactive phospholipase C-like protein 1 | |
|---|---|
| Refseq ID | NP_001108135 |
| Protein GI | 167900458 |
| UniProt ID | Q3USB7 |
| mRNA ID | NM_001114663 |
| Length | 1096 |
| RefSeq Status | PROVISIONAL |
| MAEGAASREAPAPLDVAGGEDDPRAGADAASGDAPPPALGGRMRDRRSGVALPGAAGVPADSEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFIEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDMCLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGCRSIELDVSDGPDNEPILCNRNNMAMHLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGEKLYTEAPLSSESYLPSPEKLKNMIIVKGKKLPSESDLLEGEVTDEDEEAEMSRRMSGDYNGEQKHIWLCRELSDLVSICKSVQHRDFELSMKTQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLVLHIKIISGQNFPKPKGACAKGDVIDPYVCVEIHGIPADCCEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKPQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKELCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGAIPDVQKRMLAAYDLMIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKAIESFAWNITVLKGQGDLLKNAKNEAVENIKQIQLACLSCGLSKGPGGGSEAKGKRSLEAIEEKESSEENGKL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005886 | IDA:MGI | C | plasma membrane |
| GO:0050811 | ISO:MGI | F | GABA receptor binding |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0070679 | IEA:InterPro | F | inositol 1,4,5 trisphosphate binding |
| GO:0004435 | IEA:InterPro | F | phosphatidylinositol phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0007214 | IGI:MGI | P | gamma-aminobutyric acid signaling pathway |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0006629 | IEA:InterPro | P | lipid metabolic process |
| GO:1900122 | IGI:MGI | P | positive regulation of receptor binding |
| GO:0033135 | IGI:MGI | P | regulation of peptidyl-serine phosphorylation |
| GO:0032228 | IMP:MGI | P | regulation of synaptic transmission, GABAergic |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000008 | C2 domain |
| IPR011992 | EF-hand domain pair |
| IPR028382 | Inactive phospholipase C-like protein 1 |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR001849 | Pleckstrin homology domain |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Caution | In the PI-PLC X-box Asn-459 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity. {ECO:0000305}. |
| Function | Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as a inhibitor of PPP1C (By similarity). Involved in the assembly and/or the trafficking of gamma-2 subunit-containing GABA A receptors. {ECO:0000250, ECO:0000269|PubMed:16854455, ECO:0000269|PubMed:17301177}. |
| Ptm | Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-94 resulted in dissociation of PPP1C from PRIP1. {ECO:0000269|PubMed:15306641}. |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}. |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}. |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Subunit | Interacts with PPP2CA, Ins(1,4,5)P3, Ins(1,4,5,6)P4 GABARAP, GABA receptor beta subunits, GABA receptor gamma-2 subunits and PPP1C (By similarity). May form a ternary complex with GABA receptor beta subunit and GABARAP. The formation of a ternary complex with GABA receptor beta subunit and GABARAP could be the key step for facilitating the association of GABARAP with the GABA receptor gamma-2 subunit and to allow it to be transported at the right destination. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP003604 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 167900458 | RefSeq | NP_001108135 | 1096 | inactive phospholipase C-like protein 1 |
Identical Sequences to LMP003604 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:167900458 | SwissProt | Q3USB7.3 | 1096 | RecName: Full=Inactive phospholipase C-like protein 1; Short=PLC-L1; AltName: Full=Phospholipase C-related but catalytically inactive protein; Short=PRIP [Mus musculus] |
Related Sequences to LMP003604 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:167900458 | DBBJ | BAA08351.1 | 1096 | 130kDa-Ins(1,4,5)P3 binding protein [Rattus norvegicus] |
| GI:167900458 | EMBL | CBF74568.1 | 1096 | unnamed protein product [Rattus norvegicus] |
| GI:167900458 | EMBL | CBF62890.1 | 1096 | unnamed protein product [Rattus norvegicus] |
| GI:167900458 | EMBL | CBU87766.1 | 1096 | unnamed protein product [Rattus norvegicus] |
| GI:167900458 | EMBL | CBU96713.1 | 1096 | unnamed protein product [Rattus norvegicus] |
| GI:167900458 | RefSeq | NP_445908.1 | 1096 | inactive phospholipase C-like protein 1 [Rattus norvegicus] |