Gene/Proteome Database (LMPD)
LMPD ID
LMP004644
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyl-CoA wax alcohol acyltransferase 2
Gene Symbol
Synonyms
ARAT; DC4; DGAT2L4; MFAT; WS
Alternate Names
acyl-CoA wax alcohol acyltransferase 2; retinol O-fatty-acyltransferase; multifunctional O-acyltransferase; acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase candidate 4; long-chain-alcohol O-fatty-acyltransferase 2; diacylglycerol O-acyltransferase 2-like protein 4
Chromosome
X
Map Location
Xq13.1
EC Number
2.3.1.75
Summary
This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]
Orthologs
Proteins
| acyl-CoA wax alcohol acyltransferase 2 | |
|---|---|
| Refseq ID | NP_001002254 |
| Protein GI | 51317389 |
| UniProt ID | Q6E213 |
| mRNA ID | NM_001002254 |
| Length | 333 |
| RefSeq Status | REVIEWED |
| MLLPSKKDLKTALDVFAVFQWSFSALLITTTVIAVNLYLVVFTPYWPVTVLILTWLAFDWKTPQRGGRRFTCVRHWRLWKHYSDYFPLKLLKTHDICPSRNYILVCHPHGLFAHGWFGHFATEASGFSKIFPGITPYILTLGAFFWMPFLREYVMSTGACSVSRSSIDFLLTHKGTGNMVIVVIGGLAECRYSLPGSSTLVLKNRSGFVRMALQHGVPLIPAYAFGETDLYDQHIFTPGGFVNRFQKWFQSMVHIYPCAFYGRGFTKNSWGLLPYSRPVTTIVGEPLPMPKIENPSQEIVAKYHTLYIDALRKLFDQHKTKFGISETQELEII | |
Gene Information
Entrez Gene ID
Gene Name
acyl-CoA wax alcohol acyltransferase 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | IEA:Ensembl | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0047196 | IEA:UniProtKB-EC | F | long-chain-alcohol O-fatty-acyltransferase activity |
| GO:0050252 | IEA:UniProtKB-EC | F | retinol O-fatty-acyltransferase activity |
| GO:0010025 | IEA:Ensembl | P | wax biosynthetic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR007130 | Diacylglycerol acyltransferase |
UniProt Annotations
Entry Information
Gene Name
acyl-CoA wax alcohol acyltransferase 2
Protein Entry
AWAT2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | Kinetic parameters: Vmax=1232 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate ; |
| Catalytic Activity | Acyl-CoA + a long-chain alcohol = CoA + a long-chain ester. |
| Catalytic Activity | Acyl-CoA + retinol = CoA + retinyl ester. |
| Function | Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA |
| Similarity | Belongs to the diacylglycerol acyltransferase family. |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
| Tissue Specificity | Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP004644 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 51317389 | RefSeq | NP_001002254 | 333 | acyl-CoA wax alcohol acyltransferase 2 |
Identical Sequences to LMP004644 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:51317389 | DBBJ | BAI46285.1 | 333 | acyl-CoA wax alcohol acyltransferase 2, partial [synthetic construct] |
| GI:51317389 | GenBank | ACR92676.1 | 333 | Sequence 18 from patent US 7527962 |
| GI:51317389 | GenBank | AEC33348.1 | 333 | Sequence 14 from patent US 7862819 |
| GI:51317389 | GenBank | AED72411.1 | 333 | Sequence 18 from patent US 7910346 |
| GI:51317389 | GenBank | AGC98170.1 | 333 | Sequence 18 from patent US 8334111 |
| GI:51317389 | GenBank | AHE01986.1 | 333 | Sequence 59835 from patent US 8586006 |
Related Sequences to LMP004644 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:51317389 | RefSeq | XP_529027.1 | 333 | PREDICTED: acyl-CoA wax alcohol acyltransferase 2 [Pan troglodytes] |
| GI:51317389 | RefSeq | XP_003272721.1 | 333 | PREDICTED: acyl-CoA wax alcohol acyltransferase 2 [Nomascus leucogenys] |
| GI:51317389 | RefSeq | XP_003816939.1 | 333 | PREDICTED: acyl-CoA wax alcohol acyltransferase 2 [Pan paniscus] |
| GI:51317389 | RefSeq | XP_003917878.1 | 333 | PREDICTED: acyl-CoA wax alcohol acyltransferase 2 [Papio anubis] |
| GI:51317389 | RefSeq | XP_004064369.1 | 333 | PREDICTED: acyl-CoA wax alcohol acyltransferase 2 [Gorilla gorilla gorilla] |
| GI:51317389 | RefSeq | XP_009196024.1 | 333 | PREDICTED: acyl-CoA wax alcohol acyltransferase 2 [Papio anubis] |