Gene/Proteome Database (LMPD)

LMPD ID
LMP004702
Gene ID
68018
Species
Mus musculus (Mouse)
Gene Name
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Gene Symbol
Col4a3bp
Synonyms
2810404O15Rik; 9230101K08Rik; AU016711; CERT; GPBP
Alternate Names
collagen type IV alpha-3-binding protein; stARD11; ceramide transfer protein; ceramide transport protein; START domain-containing protein 11; goodpasture antigen-binding protein; stAR-related lipid transfer protein 11; procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Chromosome
13
Map Location
13 D1|13

Proteins

collagen type IV alpha-3-binding protein isoform 1
Refseq ID NP_075909
Protein GI 12963671
UniProt ID Q9EQG9
mRNA ID NM_023420
Length 624
RefSeq Status VALIDATED
MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNTLSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPEHRQQWVDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDVCADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHNTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREESWQKRHDREVEKRRRVEEAYKNVMEELKKKPRFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDTFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMNYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIVYQTHKRVWPASQRDVLYLSAIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINIAMICQTLVSPPEGDQEISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
collagen type IV alpha-3-binding protein isoform 2
Refseq ID NP_001157694
Protein GI 255982524
UniProt ID Q9EQG9
mRNA ID NM_001164222
Length 598
RefSeq Status VALIDATED
MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNTLSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPEHRQQWVDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDVCADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHNTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREESWQKRHDREVEKRRRVEEAYKNVMEELKKKPRFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDTFSSVGTHRFVQKVEEMVQNHMNYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIVYQTHKRVWPASQRDVLYLSAIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINIAMICQTLVSPPEGDQEISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF

Gene Information

Entrez Gene ID
68018
Gene Name
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Gene Symbol
Col4a3bp
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 ISS:UniProtKB C Golgi apparatus
GO:0005829 IDA:MGI C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005739 IDA:MGI C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0097001 ISS:UniProtKB F ceramide binding
GO:0035620 ISS:UniProtKB F ceramide transporter activity
GO:0016301 IDA:MGI F kinase activity
GO:0070273 IEA:Ensembl F phosphatidylinositol-4-phosphate binding
GO:0035621 ISS:UniProtKB P ER to Golgi ceramide transport
GO:0000902 IMP:MGI P cell morphogenesis
GO:0008283 IMP:MGI P cell proliferation
GO:0006672 IMP:MGI P ceramide metabolic process
GO:0007029 IMP:MGI P endoplasmic reticulum organization
GO:0003007 IMP:MGI P heart morphogenesis
GO:0001701 IMP:MGI P in utero embryonic development
GO:0055088 IMP:MGI P lipid homeostasis
GO:0070584 IMP:MGI P mitochondrion morphogenesis
GO:0006936 IMP:MGI P muscle contraction
GO:0016310 IDA:GOC P phosphorylation
GO:0034976 IMP:MGI P response to endoplasmic reticulum stress
GO:0007165 IMP:MGI P signal transduction

REACTOME Pathway Links

REACTOME Pathway ID Description
5892760 Metabolism
5892799 Metabolism of lipids and lipoproteins
5893777 Sphingolipid de novo biosynthesis
5893778 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR023393 START-like domain
IPR002913 START_lipid-bd_dom

UniProt Annotations

Entry Information

Gene Name
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Protein Entry
C43BP_MOUSE
UniProt ID
Q9EQG9
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9EQG9-1; Sequence=Displayed; Name=2; Synonyms=Delta26, GPBPD26; IsoId=Q9EQG9-2; Sequence=VSP_006277; Name=3; IsoId=Q9EQG9-3; Sequence=VSP_028735, VSP_028736; Note=No experimental confirmation available.;
Domain The FFAT motif is required for interaction with VAPA and VAPB. {ECO:0000250}.
Domain The PH domain targets the Golgi apparatus. {ECO:0000250}.
Domain The START domain recognizes ceramides and diacylglycerol lipids, interacts with membranes, and mediates the intermembrane transfer of ceramides and diacylglycerol lipids. {ECO:0000250}.
Function Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000250}.
Ptm Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAH16197.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 START domain. {ECO:0000255|PROSITE- ProRule:PRU00197}.
Subcellular Location Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Preferentially localized to the Golgi apparatus. {ECO:0000250}.
Subunit Interacts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA (By similarity). Interacts with COL4A3. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP004702 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12963671 RefSeq NP_075909 624 collagen type IV alpha-3-binding protein isoform 1
255982524 RefSeq NP_001157694 598 collagen type IV alpha-3-binding protein isoform 2

Identical Sequences to LMP004702 proteins

Reference Database Accession Length Protein Name
GI:12963671 GenBank AAQ41912.1 624 Sequence 4 from patent US 6579969
GI:255982524 GenBank AAQ41915.1 598 Sequence 10 from patent US 6579969
GI:12963671 GenBank AAY11961.1 624 Sequence 4 from patent US 6881547
GI:255982524 GenBank AAY11964.1 598 Sequence 10 from patent US 6881547
GI:12963671 GenBank ABP13354.1 624 Sequence 4 from patent US 7186527
GI:255982524 GenBank ABP13357.1 598 Sequence 10 from patent US 7186527
GI:12963671 GenBank ABP15766.1 624 Sequence 4 from patent US 7189517
GI:255982524 GenBank ABP15769.1 598 Sequence 10 from patent US 7189517
GI:255982524 GenBank EDL00886.1 598 procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein, isoform CRA_a [Mus musculus]
GI:12963671 GenBank EDL00887.1 624 procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein, isoform CRA_b [Mus musculus]
GI:12963671 GenBank ADB99085.1 624 Sequence 4 from patent US 7629132
GI:255982524 GenBank ADB99088.1 598 Sequence 10 from patent US 7629132

Related Sequences to LMP004702 proteins

Reference Database Accession Length Protein Name
GI:255982524 DBBJ BAC26888.1 598 unnamed protein product [Mus musculus]
GI:12963671 EMBL CAH23434.1 726 unnamed protein product [Mus musculus]
GI:255982524 EMBL CAH23435.1 700 unnamed protein product [Mus musculus]
GI:12963671 GenBank AAQ89691.1 624 lipid-transfer protein CERTL [Cricetulus griseus]
GI:255982524 GenBank AAY11961.1 624 Sequence 4 from patent US 6881547
GI:12963671 GenBank EDM10117.1 624 procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein (predicted), isoform CRA_a [Rattus norvegicus]
GI:255982524 GenBank EDM10118.1 598 procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein (predicted), isoform CRA_b [Rattus norvegicus]
GI:12963671 GenBank ERE81600.1 624 collagen type IV alpha-3-binding protein [Cricetulus griseus]
GI:255982524 RefSeq NP_075909.1 624 collagen type IV alpha-3-binding protein isoform 1 [Mus musculus]
GI:12963671 RefSeq NP_001102405.1 624 collagen type IV alpha-3-binding protein [Rattus norvegicus]
GI:12963671 RefSeq NP_001230955.1 624 collagen type IV alpha-3-binding protein [Cricetulus griseus]
GI:255982524 RefSeq XP_006231889.1 598 PREDICTED: collagen type IV alpha-3-binding protein isoform X1 [Rattus norvegicus]