Gene/Proteome Database (LMPD)

LMPD ID
LMP005028
Gene ID
104709
Species
Mus musculus (Mouse)
Gene Name
phosphoinositide-3-kinase, regulatory subunit 6
Gene Symbol
Pik3r6
Synonyms
BB220380; p84; p84 PIKAP; p87(PIKAP); p87PIKAP
Alternate Names
phosphoinositide 3-kinase regulatory subunit 6; p84 PI3K adapter protein; phosphoinositide 3-kinase gamma adapter protein of 87 kDa; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
Chromosome
11
Map Location
11 B3|11
Summary
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Orthologs
View orthologs and multiple alignments for Pik3r6

Proteins

phosphoinositide 3-kinase regulatory subunit 6 isoform 1
Refseq ID NP_001075035
Protein GI 126362959
UniProt ID Q3U6Q4
mRNA ID NM_001081566
Length 756
RefSeq Status REVIEWED
MESSDVELDFQRSVQAVLRELNTPNPALQSNQGMWRWSLHKKVERNPGKSSILVRILLRELEKAESEDGRRVIIPLLLTLMSVLTKATGIPEDLYHRAYTFCTRLLTLPAPYSTVALDCAIRLKTETAVPGTLYQRTVIAEQNLISELYPYQERVFLFVDPELVSASVCSALLLEIQAAQEQQTPEACMRHVVSHALQAALGEACHTGALNRKLQASSRRVLEYYFHAVVAAIEQVASEDSPSRLGHLEKMEEIYCSLLGPATTRRHCVGDLLQDRLPSIPLPSPYITFHLWTDQEQLWKELVLFLRPRSQLRLSADLDALDLQGFRLDRDLARVSTDSGIERDLPLGSDELPDPSSSEMERAALQRKGGIKKRVWPPDFFMPGSWDGPPGLHRRTGRPSGDGELLPGVSRVHTARVLVLGDDRMLGRLAQAYYRLRKRETKKFCLTPRLSLQLYYIPVLAPQVTGQDPEASRKPELGELASFLGRVDPWYESTVNTLCPAILKLAEMPPYLDTSRTVDPFILDVITYYVRMGTQPIYFQLYKVKIFTSLSHDPTEDIFLTELKVKIQDSKSPKEGSSPRRRGAAEGTGAELSMCYQKALLSHRPREVTVSLRATGLVLKAIPAGDTEVSGFFHCTSPNAASATDCSCLHVSVTEVVKSSNLAGRSFTTSTNTFRTSSIQVQSQDQRLLTLWLDKDGRRTFRDVVRFEVSPCPEPCSRTQKSKTSALNSHGQETEKNMAKPNSLLMPINTFSGIIQ
phosphoinositide 3-kinase regulatory subunit 6 isoform 2
Refseq ID NP_001004435
Protein GI 52138727
UniProt ID Q3U6Q4
mRNA ID NM_001004435
Length 752
RefSeq Status REVIEWED
MESSDVELDFQRSVQAVLRELNTPNPALQSNQGMWRWSLHKKVERNPGKSSILVRILLRELEKAESEDGRRVIIPLLLTLMSVLTKATGIPEDLYHRAYTFCTRLLTLPAPYSTVALDCAIRLKTETAVPGTLYQRTVIAEQNLISELYPYQERVFLFVDPELVSASVCSALLLEIQAAQEQQTPEACMRHVVSHALQAALGEACHTGALNRKLQASSRRVLEYYFHAVVAAIEQVASEDSPSRLGHLEKMEEIYCSLLGPATTRRHCVGDLLQDRLPSIPLPSPYITFHLWTDQEQLWKELVLFLRPRSQLRLSADLDALDLQGFRLDRDLARVSTDSGIERDLPLGSDELPDPSSSEMERAALQRKGGIKKRVWPPDFFMPGSWDGPPGLHRRTGRPSGDGELLPGVSRVHTARVLVLGDDRMLGRLAQAYYRLRKRETKKFCLTPRLSLQLYYIPVLAPQDPEASRKPELGELASFLGRVDPWYESTVNTLCPAILKLAEMPPYLDTSRTVDPFILDVITYYVRMGTQPIYFQLYKVKIFTSLSHDPTEDIFLTELKVKIQDSKSPKEGSSPRRRGAAEGTGAELSMCYQKALLSHRPREVTVSLRATGLVLKAIPAGDTEVSGFFHCTSPNAASATDCSCLHVSVTEVVKSSNLAGRSFTTSTNTFRTSSIQVQSQDQRLLTLWLDKDGRRTFRDVVRFEVSPCPEPCSRTQKSKTSALNSHGQETEKNMAKPNSLLMPINTFSGIIQ

Gene Information

Entrez Gene ID
104709
Gene Name
phosphoinositide-3-kinase, regulatory subunit 6
Gene Symbol
Pik3r6
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IDA:UniProtKB C membrane
GO:0005944 IDA:UniProtKB C phosphatidylinositol 3-kinase complex, class IB
GO:0046935 IDA:UniProtKB F 1-phosphatidylinositol-3-kinase regulator activity
GO:0007186 IDA:UniProtKB P G-protein coupled receptor signaling pathway
GO:0001525 IEA:UniProtKB-KW P angiogenesis
GO:0046854 IDA:GOC P phosphatidylinositol phosphorylation
GO:0043406 IDA:UniProtKB P positive regulation of MAP kinase activity
GO:0045766 ISS:UniProtKB P positive regulation of angiogenesis
GO:0043551 IDA:GOC P regulation of phosphatidylinositol 3-kinase activity

REACTOME Pathway Links

REACTOME Pathway ID Description
5893512 G beta:gamma signalling through PI3Kgamma
5893161 GPVI-mediated activation cascade
5894009 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR019522 Phosphoinositide 3-kinase regulatory subunit 5/6

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase, regulatory subunit 6
Protein Entry
PI3R6_MOUSE
UniProt ID
Q3U6Q4
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U6Q4-1; Sequence=Displayed; Name=2; IsoId=Q3U6Q4-2; Sequence=VSP_018257; Name=3; IsoId=Q3U6Q4-3; Sequence=VSP_018255, VSP_018256; Note=No experimental confirmation available.;
Function Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:15797027, ECO:0000269|PubMed:16476736, ECO:0000269|PubMed:19906996}.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein.
Subunit Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG. Interacts with beta-gamma G protein dimers. Interacts with PDE3B; the interaction allows recruitment of the PI3K gamma complex to a PDE3B:RAPGEF3 complex. {ECO:0000269|PubMed:15797027, ECO:0000269|PubMed:16476736}.
Tissue Specificity Highly expressed in heart. In a lower extent, also expressed in brain, spleen, lung, liver, kidney, prostate, thyroid, salivary gland, dendritic cells, macrophages and neutrophils. {ECO:0000269|PubMed:16476736}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005028 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
126362959 RefSeq NP_001075035 756 phosphoinositide 3-kinase regulatory subunit 6 isoform 1
52138727 RefSeq NP_001004435 752 phosphoinositide 3-kinase regulatory subunit 6 isoform 2

Identical Sequences to LMP005028 proteins

Reference Database Accession Length Protein Name
GI:126362959 DBBJ BAE31670.1 756 unnamed protein product [Mus musculus]
GI:52138727 GenBank AAH28998.1 752 Phosphoinositide-3-kinase, regulatory subunit 6 [Mus musculus]
GI:52138727 GenBank AAV30089.1 752 p87 phosphoinositide 3-kinase gamma adapter protein [Mus musculus]
GI:126362959 GenBank ABB97395.1 756 p87 phosphoinositide 3-kinase gamma adapter protein long splice variant [Mus musculus]
GI:126362959 SwissProt Q3U6Q4.1 756 RecName: Full=Phosphoinositide 3-kinase regulatory subunit 6; AltName: Full=Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; AltName: Full=p84 PI3K adapter protein; Short=p84 PIKAP; AltName: Full=p87 PI3K adapter protein; Short=p87PIKAP [Mus musculus]

Related Sequences to LMP005028 proteins

Reference Database Accession Length Protein Name
GI:126362959 DBBJ BAE30180.1 756 unnamed protein product [Mus musculus]
GI:52138727 DBBJ BAE30180.1 756 unnamed protein product [Mus musculus]
GI:52138727 DBBJ BAE31670.1 756 unnamed protein product [Mus musculus]
GI:126362959 GenBank AAH28998.1 752 Phosphoinositide-3-kinase, regulatory subunit 6 [Mus musculus]
GI:126362959 GenBank AAV30089.1 752 p87 phosphoinositide 3-kinase gamma adapter protein [Mus musculus]
GI:52138727 GenBank ABB97395.1 756 p87 phosphoinositide 3-kinase gamma adapter protein long splice variant [Mus musculus]
GI:126362959 GenBank ABM92928.1 756 p87 phosphoinositide 3-kinase gamma adapter protein [Rattus norvegicus]
GI:126362959 RefSeq NP_001004435.1 752 phosphoinositide 3-kinase regulatory subunit 6 isoform 2 [Mus musculus]
GI:126362959 RefSeq NP_001074913.1 756 phosphoinositide 3-kinase regulatory subunit 6 [Rattus norvegicus]
GI:52138727 RefSeq NP_001074913.1 756 phosphoinositide 3-kinase regulatory subunit 6 [Rattus norvegicus]
GI:52138727 RefSeq NP_001075035.1 756 phosphoinositide 3-kinase regulatory subunit 6 isoform 1 [Mus musculus]
GI:52138727 SwissProt Q3U6Q4.1 756 RecName: Full=Phosphoinositide 3-kinase regulatory subunit 6; AltName: Full=Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; AltName: Full=p84 PI3K adapter protein; Short=p84 PIKAP; AltName: Full=p87 PI3K adapter protein; Short=p87PIKAP [Mus musculus]