Gene/Proteome Database (LMPD)

LMPD ID
LMP005253
Gene ID
376497
Species
Homo sapiens (Human)
Gene Name
solute carrier family 27 (fatty acid transporter), member 1
Gene Symbol
SLC27A1
Synonyms
ACSVL5; FATP; FATP1
Alternate Names
long-chain fatty acid transport protein 1; FATP-1; fatty acid transport protein 1; solute carrier family 27 member 1
Chromosome
19
Map Location
19p13.11
EC Number
6.2.1.-

Proteins

long-chain fatty acid transport protein 1
Refseq ID NP_940982
Protein GI 38524616
UniProt ID Q6PCB7
mRNA ID NM_198580
Length 646
RefSeq Status PROVISIONAL
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL

Gene Information

Entrez Gene ID
376497
Gene Name
solute carrier family 27 (fatty acid transporter), member 1
Gene Symbol
SLC27A1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0015245 IEA:Ensembl F fatty acid transporter activity
GO:0000166 IEA:UniProtKB-KW F nucleotide binding
GO:0031957 IEA:Ensembl F very long-chain fatty acid-CoA ligase activity
GO:0033211 IEA:Ensembl P adiponectin-activated signaling pathway
GO:0032049 IMP:UniProtKB P cardiolipin biosynthetic process
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0015909 TAS:Reactome P long-chain fatty acid transport
GO:0001579 IEA:Ensembl P medium-chain fatty acid transport
GO:0071072 IMP:UniProtKB P negative regulation of phospholipid biosynthetic process
GO:0006654 IMP:UniProtKB P phosphatidic acid biosynthetic process
GO:0006656 IMP:UniProtKB P phosphatidylcholine biosynthetic process
GO:0006646 IMP:UniProtKB P phosphatidylethanolamine biosynthetic process
GO:0006655 IMP:UniProtKB P phosphatidylglycerol biosynthetic process
GO:0006661 IMP:UniProtKB P phosphatidylinositol biosynthetic process
GO:0006659 IMP:UniProtKB P phosphatidylserine biosynthetic process
GO:0031652 IEA:Ensembl P positive regulation of heat generation
GO:0071902 IEA:Ensembl P positive regulation of protein serine/threonine kinase activity
GO:0009409 IEA:Ensembl P response to cold
GO:0032868 IEA:Ensembl P response to insulin
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0055085 TAS:Reactome P transmembrane transport

KEGG Pathway Links

KEGG Pathway ID Description
hsa03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116145 PPARA activates gene expression
REACT_19241 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_23892 Transport of fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
solute carrier family 27 (fatty acid transporter), member 1
Protein Entry
S27A1_HUMAN
UniProt ID
Q6PCB7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PCB7-1; Sequence=Displayed; Name=2; IsoId=Q6PCB7-2; Sequence=VSP_055806, VSP_055807; Note=No experimental confirmation available.;
Function Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).
Miscellaneous FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.
Subcellular Location Cell membrane ; Single-pass membrane protein . Endomembrane system ; Single-pass membrane protein . Cytoplasm . Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes (By similarity).
Subunit Self-associates. May function as a homodimer (By similarity).
Tissue Specificity Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP005253 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
38524616 RefSeq NP_940982 646 long-chain fatty acid transport protein 1

Identical Sequences to LMP005253 proteins

Reference Database Accession Length Protein Name
GI:38524616 GenBank ABH70727.1 646 Sequence 25 from patent US 7033772
GI:38524616 GenBank ABH70729.1 646 Sequence 32 from patent US 7033772
GI:38524616 GenBank ABH70734.1 646 Sequence 38 from patent US 7033772
GI:38524616 GenBank ABH70739.1 646 Sequence 43 from patent US 7033772
GI:38524616 GenBank ABH70741.1 646 Sequence 47 from patent US 7033772
GI:38524616 GenBank EAW84611.1 646 solute carrier family 27 (fatty acid transporter), member 1, isoform CRA_c [Homo sapiens]

Related Sequences to LMP005253 proteins

Reference Database Accession Length Protein Name
GI:38524616 EMBL CAC07591.1 646 unnamed protein product [Homo sapiens]
GI:38524616 GenBank EHH59350.1 646 Long-chain fatty acid transport protein 1 [Macaca fascicularis]
GI:38524616 RefSeq XP_005588442.1 646 PREDICTED: long-chain fatty acid transport protein 1 isoform X1 [Macaca fascicularis]
GI:38524616 RefSeq XP_006722812.1 673 PREDICTED: long-chain fatty acid transport protein 1 isoform X1 [Homo sapiens]
GI:38524616 RefSeq XP_010359744.1 646 PREDICTED: long-chain fatty acid transport protein 1 isoform X1 [Rhinopithecus roxellana]
GI:38524616 RefSeq XP_010359745.1 646 PREDICTED: long-chain fatty acid transport protein 1 isoform X1 [Rhinopithecus roxellana]