Gene/Proteome Database (LMPD)

LMPD ID
LMP005762
Gene ID
68263
Species
Mus musculus (Mouse)
Gene Name
pyruvate dehydrogenase (lipoamide) beta
Gene Symbol
Pdhb
Synonyms
2610103L06Rik; AL024199; C81408
Alternate Names
pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B
Chromosome
14
Map Location
14 A1|14
EC Number
1.2.4.1

Proteins

pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor
Refseq ID NP_077183
Protein GI 18152793
UniProt ID Q9D051
mRNA ID NM_024221
Length 359
RefSeq Status VALIDATED
MAVVAGLVRGPLRQASGLLKRRFHRSAPAAVQLTVREAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVMLENELMYGVAFELPAEAQSKDFLIPIGKAKIERQGTHITVVAHSRPVGHCLEAAAVLSKEGIECEVINLRTIRPMDIEAIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKVLEDNSVPQVKDIIFAVKKTLNI
transit_peptide: 1..30 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9D051.1) calculated_mol_wt: 3187 peptide sequence: MAVVAGLVRGPLRQASGLLKRRFHRSAPAA mat_peptide: 31..359 product: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9D051.1) calculated_mol_wt: 35768 peptide sequence: VQLTVREAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVMLENELMYGVAFELPAEAQSKDFLIPIGKAKIERQGTHITVVAHSRPVGHCLEAAAVLSKEGIECEVINLRTIRPMDIEAIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKVLEDNSVPQVKDIIFAVKKTLNI

Gene Information

Entrez Gene ID
68263
Gene Name
pyruvate dehydrogenase (lipoamide) beta
Gene Symbol
Pdhb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:MGI C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0045254 ISS:UniProtKB C pyruvate dehydrogenase complex
GO:0004739 IEA:UniProtKB-EC F pyruvate dehydrogenase (acetyl-transferring) activity
GO:0004738 ISS:UniProtKB F pyruvate dehydrogenase activity
GO:0006086 ISS:UniProtKB P acetyl-CoA biosynthetic process from pyruvate
GO:0006006 IEA:UniProtKB-KW P glucose metabolic process
GO:0006099 ISS:UniProtKB P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism
mmu00020 Citrate cycle (TCA cycle)
mmu00010 Glycolysis / Gluconeogenesis
mmu04066 HIF-1 signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR027110 Pyruvate dehydrogenase E1 component subunit beta
IPR029061 Thiamin diphosphate-binding fold
IPR005476 Transketolase, C-terminal
IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
IPR005475 Transketolase-like, pyrimidine-binding domain

UniProt Annotations

Entry Information

Gene Name
pyruvate dehydrogenase (lipoamide) beta
Protein Entry
ODPB_MOUSE
UniProt ID
Q9D051
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
Cofactor Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250};
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000250}.
Sequence Caution Sequence=AAH02188.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Subcellular Location Mitochondrion matrix {ECO:0000250}.
Subunit Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP005762 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18152793 RefSeq NP_077183 359 pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor

Identical Sequences to LMP005762 proteins

Reference Database Accession Length Protein Name
GI:18152793 DBBJ BAB27855.1 359 unnamed protein product [Mus musculus]
GI:18152793 DBBJ BAE31684.1 359 unnamed protein product [Mus musculus]
GI:18152793 GenBank AAH19512.1 359 Pyruvate dehydrogenase (lipoamide) beta [Mus musculus]
GI:18152793 GenBank AAH94468.1 359 Pyruvate dehydrogenase (lipoamide) beta [Mus musculus]
GI:18152793 SwissProt Q9D051.1 359 RecName: Full=Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Short=PDHE1-B; Flags: Precursor [Mus musculus]

Related Sequences to LMP005762 proteins

Reference Database Accession Length Protein Name
GI:18152793 DBBJ BAE38906.1 359 unnamed protein product [Mus musculus]
GI:18152793 GenBank AAH79137.1 359 Pyruvate dehydrogenase (lipoamide) beta [Rattus norvegicus]
GI:18152793 RefSeq NP_001007621.1 359 pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor [Rattus norvegicus]
GI:18152793 RefSeq XP_006251816.1 359 PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform X1 [Rattus norvegicus]
GI:18152793 RefSeq XP_006994806.1 359 PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial [Peromyscus maniculatus bairdii]
GI:18152793 SwissProt P49432.2 359 RecName: Full=Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; Short=PDHE1-B; Flags: Precursor [Rattus norvegicus]