Gene/Proteome Database (LMPD)

LMPD ID
LMP006578
Gene ID
13863
Species
Mus musculus (Mouse)
Gene Name
lipocalin 5
Gene Symbol
Lcn5
Synonyms
E-RABP; Erabp; MEP10
Chromosome
2
Map Location
2|2
Summary
This gene encodes a small secreted protein that is expressed in the epididymis and binds retinoic acid. The precursor protein is processed into both a longer major form and a shorter minor form. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Orthologs
View orthologs and multiple alignments for Lcn5

Proteins

epididymal-specific lipocalin-5 isoform a precursor
Refseq ID NP_031973
Protein GI 110835737
UniProt ID A2AJB7
mRNA ID NM_007947
Length 192
RefSeq Status REVIEWED
MCSVARHMESIMLFTLLGLCVGLAAGTEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDLTCVNALQSGQI
mat_peptide: 27..180 product: major form calculated_mol_wt: 17079 peptide sequence: TEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHD mat_peptide: 30..180 product: minor form exception: alternative processing calculated_mol_wt: 16777 peptide sequence: AVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHD mat_peptide: 27..192 product: major form calculated_mol_wt: 18376 peptide sequence: TEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDYIEIKALPKPGS mat_peptide: 30..192 product: minor form exception: alternative processing calculated_mol_wt: 18075 peptide sequence: AVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDYIEIKALPKPGS mat_peptide: 27..192 product: major form calculated_mol_wt: 18307 peptide sequence: TEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDLTCVNALQSGQI mat_peptide: 30..192 product: minor form exception: alternative processing calculated_mol_wt: 18006 peptide sequence: AVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDLTCVNALQSGQI
epididymal-specific lipocalin-5 isoform b precursor
Refseq ID NP_001036095
Protein GI 110835735
UniProt ID A2AJB7
mRNA ID NM_001042630
Length 180
RefSeq Status REVIEWED
MCSVARHMESIMLFTLLGLCVGLAAGTEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHD
epididymal-specific lipocalin-5 isoform c precursor
Refseq ID NP_001263186
Protein GI 442734435
UniProt ID A2AJB7
mRNA ID NM_001276257
Length 192
RefSeq Status REVIEWED
MCSVARHMESIMLFTLLGLCVGLAAGTEAAVVKDFDVNKFLGFWYEIALASKMGAYGLAHKEEKMGAMVVELKENLLALTTTYYNEGHCVLEKVAATQVDGSAKYKVTRISGEKEVVVVATDYMTYTVIDITSLVAGAVHRAMKLYSRSLDNNGEALNNFQKIALKHGFSETDIHILKHDYIEIKALPKPGS

Gene Information

Entrez Gene ID
13863
Gene Name
lipocalin 5
Gene Symbol
Lcn5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 TAS:MGI C extracellular space
GO:0005501 TAS:MGI F retinoid binding
GO:0036094 IEA:InterPro F small molecule binding
GO:0005215 IEA:InterPro F transporter activity
GO:0042573 TAS:MGI P retinoic acid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR002345 Lipocalin
IPR022272 Lipocalin family conserved site
IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002972 Prostaglandin D synthase

UniProt Annotations

Entry Information

Gene Name
lipocalin 5
Protein Entry
A2AJB7_MOUSE
UniProt ID
A2AJB7
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1 ; IsoId=A2AJB7-1; Sequence=Displayed; Name=2 ; IsoId=A2AJB7-2; Sequence=VSP_052839; Note=No experimental confirmation available. ; Name=3 ; IsoId=A2AJB7-3; Sequence=VSP_052840; Note=No experimental confirmation available. ; Name=4 ; IsoId=A2AJB7-4; Sequence=VSP_052838;
Function Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation.
Induction Down-regulated to 11% of control levels 5 days after castration and is not detectable by 20 days (at protein level). Levels are partially restored by subsequent testosterone treatment.
Ptm 2 different forms with differently processed N-termini exist.
Sequence Caution Sequence=AAD09351.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the calycin superfamily. Lipocalin family.
Subcellular Location Secreted {ECO:0000269|PubMed:1591332, ECO:0000269|PubMed:2393684}. Note=Synthesized by the mid and distal caput of the epididymis and secreted into the epididymal lumen.
Tissue Specificity Epididymal fluid of the caudal and corpus regions (at protein level).

Identical and Related Proteins

Unique RefSeq proteins for LMP006578 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
110835737 RefSeq NP_031973 192 epididymal-specific lipocalin-5 isoform a precursor
110835735 RefSeq NP_001036095 180 epididymal-specific lipocalin-5 isoform b precursor
442734435 RefSeq NP_001263186 192 epididymal-specific lipocalin-5 isoform c precursor

Identical Sequences to LMP006578 proteins

Reference Database Accession Length Protein Name
GI:110835735 DBBJ BAE36871.1 180 unnamed protein product [Mus musculus]
GI:442734435 DBBJ BAE23077.1 192 unnamed protein product [Mus musculus]
GI:110835737 GenBank AAI40406.1 192 Lipocalin 5, partial [synthetic construct]
GI:110835737 GenBank AAI46486.1 192 Lipocalin 5 [synthetic construct]
GI:110835737 SwissProt A2AJB7.1 192 RecName: Full=Epididymal-specific lipocalin-5; AltName: Full=Epididymal retinoic acid-binding protein; Short=E-RABP; Short=mE-RABP; AltName: Full=Epididymal secretory protein 10; Short=MEP 10; Contains: RecName: Full=Epididymal-specific lipocalin-5, major form; Contains: RecName: Full=Epididymal-specific lipocalin-5, minor form; Flags: Precursor [Mus musculus]

Related Sequences to LMP006578 proteins

Reference Database Accession Length Protein Name
GI:110835735 DBBJ BAE23077.1 192 unnamed protein product [Mus musculus]
GI:110835737 GenBank AAD09351.1 185 epididymal retinoic acid binding protein [Mus musculus]
GI:442734435 GenBank AAI40406.1 192 Lipocalin 5, partial [synthetic construct]
GI:110835735 GenBank AAI40406.1 192 Lipocalin 5, partial [synthetic construct]
GI:110835737 GenBank EDL08270.1 185 lipocalin 5 [Mus musculus]
GI:110835735 GenBank AAI46486.1 192 Lipocalin 5 [synthetic construct]
GI:442734435 GenBank AAI46486.1 192 Lipocalin 5 [synthetic construct]
GI:110835735 RefSeq NP_031973.2 192 epididymal-specific lipocalin-5 isoform a precursor [Mus musculus]
GI:442734435 RefSeq NP_031973.2 192 epididymal-specific lipocalin-5 isoform a precursor [Mus musculus]
GI:110835737 RefSeq NP_001263186.1 192 epididymal-specific lipocalin-5 isoform c precursor [Mus musculus]
GI:110835735 RefSeq NP_001263186.1 192 epididymal-specific lipocalin-5 isoform c precursor [Mus musculus]
GI:442734435 RefSeq XP_006497728.1 208 PREDICTED: epididymal-specific lipocalin-5 isoform X1 [Mus musculus]
GI:110835737 RefSeq XP_006497729.1 202 PREDICTED: epididymal-specific lipocalin-5 isoform X2 [Mus musculus]
GI:442734435 RefSeq XP_006497729.1 202 PREDICTED: epididymal-specific lipocalin-5 isoform X2 [Mus musculus]
GI:110835737 RefSeq XP_006497730.1 190 PREDICTED: epididymal-specific lipocalin-5 isoform X3 [Mus musculus]
GI:110835737 RefSeq XP_006497731.1 190 PREDICTED: epididymal-specific lipocalin-5 isoform X4 [Mus musculus]
GI:442734435 SwissProt A2AJB7.1 192 RecName: Full=Epididymal-specific lipocalin-5; AltName: Full=Epididymal retinoic acid-binding protein; Short=E-RABP; Short=mE-RABP; AltName: Full=Epididymal secretory protein 10; Short=MEP 10; Contains: RecName: Full=Epididymal-specific lipocalin-5, major form; Contains: RecName: Full=Epididymal-specific lipocalin-5, minor form; Flags: Precursor [Mus musculus]
GI:110835735 SwissProt A2AJB7.1 192 RecName: Full=Epididymal-specific lipocalin-5; AltName: Full=Epididymal retinoic acid-binding protein; Short=E-RABP; Short=mE-RABP; AltName: Full=Epididymal secretory protein 10; Short=MEP 10; Contains: RecName: Full=Epididymal-specific lipocalin-5, major form; Contains: RecName: Full=Epididymal-specific lipocalin-5, minor form; Flags: Precursor [Mus musculus]