Gene/Proteome Database (LMPD)

LMPD ID
LMP006690
Gene ID
5375
Species
Homo sapiens (Human)
Gene Name
peripheral myelin protein 2
Gene Symbol
PMP2
Synonyms
FABP8; M-FABP; MP2; P2
Alternate Names
myelin P2 protein
Chromosome
8
Map Location
8q21.3-q22.1

Proteins

myelin P2 protein
Refseq ID NP_002668
Protein GI 4505909
UniProt ID P02689
mRNA ID NM_002677
Length 132
RefSeq Status VALIDATED
MSNKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDIITIRTESTFKNTEISFKLGQEFEETTADNRKTKSIVTLQRGSLNQVQRWDGKETTIKRKLVNGKMVAECKMKGVVCTRIYEKV

Gene Information

Entrez Gene ID
5375
Gene Name
peripheral myelin protein 2
Gene Symbol
PMP2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0015485 IDA:UniProtKB F cholesterol binding
GO:0005504 IDA:UniProtKB F fatty acid binding
GO:0005215 IEA:InterPro F transporter activity
GO:0061024 IEA:Ensembl P membrane organization

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
peripheral myelin protein 2
Protein Entry
MYP2_HUMAN
UniProt ID
P02689
Species
Human

Comments

Comment Type Description
Domain Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Function May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
Miscellaneous P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.
Similarity Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Subcellular Location Cytoplasm .
Subunit Monomer.

Identical and Related Proteins

Unique RefSeq proteins for LMP006690 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4505909 RefSeq NP_002668 132 myelin P2 protein

Identical Sequences to LMP006690 proteins

Reference Database Accession Length Protein Name
GI:4505909 DBBJ BAI46630.1 132 Myelin P2 protein, partial [synthetic construct]
GI:4505909 GenBank ACM80762.1 132 Sequence 6260 from patent US 6812339
GI:4505909 GenBank AHD73886.1 132 Sequence 12344 from patent US 8586006
GI:4505909 GenBank AIC49421.1 132 PMP2, partial [synthetic construct]
GI:4505909 RefSeq XP_003831318.1 132 PREDICTED: myelin P2 protein [Pan paniscus]
GI:4505909 RefSeq XP_004047246.1 132 PREDICTED: myelin P2 protein [Gorilla gorilla gorilla]

Related Sequences to LMP006690 proteins

Reference Database Accession Length Protein Name
GI:4505909 GenBank AAX29887.1 133 peripheral myelin protein 2, partial [synthetic construct]
GI:4505909 GenBank AAX37130.1 133 peripheral myelin protein 2, partial [synthetic construct]
GI:4505909 GenBank ACM81912.1 141 Sequence 7410 from patent US 6812339
GI:4505909 PDB 2WUT 133 Chain A, Crystal Structure Of Human Myelin Protein P2 In Complex With Palmitate
GI:4505909 PDB 4BVM 133 Chain A, The Peripheral Membrane Protein P2 From Human Myelin At Atomic Resolution
GI:4505909 RefSeq XP_002819259.1 132 PREDICTED: myelin P2 protein isoform X1 [Pongo abelii]