Gene/Proteome Database (LMPD)
LMPD ID
LMP006698
Gene ID
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein-like 3
Gene Symbol
Synonyms
ORP-3; ORP3; OSBP3
Alternate Names
oxysterol-binding protein-related protein 3; OSBP-related protein 3
Chromosome
7
Map Location
7p15
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Orthologs
Proteins
| oxysterol-binding protein-related protein 3 isoform a | |
|---|---|
| Refseq ID | NP_056365 |
| Protein GI | 14149704 |
| UniProt ID | Q9H4L5 |
| mRNA ID | NM_015550 |
| Length | 887 |
| RefSeq Status | REVIEWED |
| MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHRTYSAPAINAIQGGSFESPKKEKRSHRRWRSRAIGKDAKGTLQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSALAQNTDLKERLRRIHAESLLLDSPAVAKSGDNLAEENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDSWVSNGTYLELRKDLGFSKLDHPVLW | |
| oxysterol-binding protein-related protein 3 isoform b | |
|---|---|
| Refseq ID | NP_663160 |
| Protein GI | 21735580 |
| UniProt ID | Q9H4L5 |
| mRNA ID | NM_145320 |
| Length | 856 |
| RefSeq Status | REVIEWED |
| MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHRTYSAPAINAIQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSALAQNTDLKERLRRIHAESLLLDSPAVAKSGDNLAEENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDSWVSNGTYLELRKDLGFSKLDHPVLW | |
| oxysterol-binding protein-related protein 3 isoform c | |
|---|---|
| Refseq ID | NP_663161 |
| Protein GI | 21735582 |
| UniProt ID | Q9H4L5 |
| mRNA ID | NM_145321 |
| Length | 851 |
| RefSeq Status | REVIEWED |
| MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHRTYSAPAINAIQGGSFESPKKEKRSHRRWRSRAIGKDAKGTLQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDSWVSNGTYLELRKDLGFSKLDHPVLW | |
| oxysterol-binding protein-related protein 3 isoform d | |
|---|---|
| Refseq ID | NP_663162 |
| Protein GI | 21735584 |
| UniProt ID | Q9H4L5 |
| mRNA ID | NM_145322 |
| Length | 820 |
| RefSeq Status | REVIEWED |
| MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHRTYSAPAINAIQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDSWVSNGTYLELRKDLGFSKLDHPVLW | |
Gene Information
Entrez Gene ID
Gene Name
oxysterol binding protein-like 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:BHF-UCL | C | cytosol |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0031965 | IDA:BHF-UCL | C | nuclear membrane |
| GO:0097038 | IDA:BHF-UCL | C | perinuclear endoplasmic reticulum |
| GO:0005886 | IDA:BHF-UCL | C | plasma membrane |
| GO:0015485 | IDA:BHF-UCL | F | cholesterol binding |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
oxysterol binding protein-like 3
Protein Entry
OSBL3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=8; Name=1a; IsoId=Q9H4L5-1; Sequence=Displayed; Name=1b; IsoId=Q9H4L5-2; Sequence=VSP_008219; Name=1c; IsoId=Q9H4L5-3; Sequence=VSP_008220; Name=1d; IsoId=Q9H4L5-4; Sequence=VSP_008219, VSP_008220; Name=2a; IsoId=Q9H4L5-5; Sequence=VSP_008221, VSP_008222; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=2b; IsoId=Q9H4L5-6; Sequence=VSP_008219, VSP_008221, VSP_008222; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=2c; IsoId=Q9H4L5-7; Sequence=VSP_008220, VSP_008221, VSP_008222; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=2d; IsoId=Q9H4L5-8; Sequence=VSP_008219, VSP_008220, VSP_008221, VSP_008222; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; |
| Interaction | Q9Q2G4:ORF (xeno); NbExp=5; IntAct=EBI-1051317, EBI-6248094; |
| Sequence Caution | Sequence=BAA31679.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; |
| Similarity | Belongs to the OSBP family. |
| Similarity | Contains 1 PH domain. {ECO |
| Tissue Specificity | Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006698 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 14149704 | RefSeq | NP_056365 | 887 | oxysterol-binding protein-related protein 3 isoform a |
| 21735580 | RefSeq | NP_663160 | 856 | oxysterol-binding protein-related protein 3 isoform b |
| 21735582 | RefSeq | NP_663161 | 851 | oxysterol-binding protein-related protein 3 isoform c |
| 21735584 | RefSeq | NP_663162 | 820 | oxysterol-binding protein-related protein 3 isoform d |
Identical Sequences to LMP006698 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:14149704 | DBBJ | BAG09817.1 | 887 | oxysterol-binding protein-related protein 3, partial [synthetic construct] |
| GI:21735582 | GenBank | AAM27388.1 | 851 | oxysterol binding protein-related protein 3 isoform 1c [Homo sapiens] |
| GI:21735584 | GenBank | AAM27389.1 | 820 | oxysterol binding protein-related protein 3 isoform 1d [Homo sapiens] |
| GI:21735582 | GenBank | EAL24241.1 | 851 | oxysterol binding protein-like 3 [Homo sapiens] |
| GI:21735580 | GenBank | EAL24242.1 | 856 | oxysterol binding protein-like 3 [Homo sapiens] |
| GI:21735584 | GenBank | EAL24243.1 | 820 | oxysterol binding protein-like 3 [Homo sapiens] |
| GI:21735582 | GenBank | EAW93819.1 | 851 | hCG38836, isoform CRA_e [Homo sapiens] |
| GI:21735584 | GenBank | EAW93820.1 | 820 | hCG38836, isoform CRA_f [Homo sapiens] |
| GI:21735580 | GenBank | EAW93821.1 | 856 | hCG38836, isoform CRA_g [Homo sapiens] |
| GI:21735580 | GenBank | JAA21894.1 | 856 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:14149704 | GenBank | JAA21895.1 | 887 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:21735580 | GenBank | JAA43675.1 | 856 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:14149704 | GenBank | JAA43676.1 | 887 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:21735584 | GenBank | JAA43677.1 | 820 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:14149704 | RefSeq | XP_003807971.1 | 887 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Pan paniscus] |
| GI:21735580 | RefSeq | XP_003807972.1 | 856 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X2 [Pan paniscus] |
| GI:21735582 | RefSeq | XP_003807973.1 | 851 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X3 [Pan paniscus] |
| GI:21735584 | RefSeq | XP_003807974.1 | 820 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X5 [Pan paniscus] |
| GI:14149704 | RefSeq | XP_005249755.1 | 887 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Homo sapiens] |
| GI:21735580 | RefSeq | XP_006715744.1 | 856 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X2 [Homo sapiens] |
| GI:21735582 | RefSeq | XP_006715745.1 | 851 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X3 [Homo sapiens] |
| GI:21735584 | RefSeq | XP_006715746.1 | 820 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X4 [Homo sapiens] |
| GI:14149704 | RefSeq | XP_008958281.1 | 887 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Pan paniscus] |
Related Sequences to LMP006698 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:14149704 | DBBJ | BAA31679.2 | 919 | KIAA0704 protein, partial [Homo sapiens] |
| GI:21735580 | DBBJ | BAA31679.2 | 919 | KIAA0704 protein, partial [Homo sapiens] |
| GI:21735582 | DBBJ | BAA31679.2 | 919 | KIAA0704 protein, partial [Homo sapiens] |
| GI:21735584 | GenBank | AAM27388.1 | 851 | oxysterol binding protein-related protein 3 isoform 1c [Homo sapiens] |
| GI:21735584 | GenBank | EAL24241.1 | 851 | oxysterol binding protein-like 3 [Homo sapiens] |
| GI:21735584 | GenBank | EAW93819.1 | 851 | hCG38836, isoform CRA_e [Homo sapiens] |
| GI:14149704 | GenBank | JAA07788.1 | 887 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:21735580 | GenBank | JAA07789.1 | 856 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:21735582 | GenBank | JAA21895.1 | 887 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:21735580 | GenBank | JAA21895.1 | 887 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:21735580 | GenBank | JAA30264.1 | 856 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:14149704 | GenBank | JAA30265.1 | 887 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:21735582 | GenBank | JAA43676.1 | 887 | oxysterol binding protein-like 3 [Pan troglodytes] |
| GI:21735580 | RefSeq | NP_056365.1 | 887 | oxysterol-binding protein-related protein 3 isoform a [Homo sapiens] |
| GI:21735582 | RefSeq | NP_056365.1 | 887 | oxysterol-binding protein-related protein 3 isoform a [Homo sapiens] |
| GI:21735584 | RefSeq | NP_663161.1 | 851 | oxysterol-binding protein-related protein 3 isoform c [Homo sapiens] |
| GI:14149704 | RefSeq | XP_001160331.2 | 887 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Pan troglodytes] |
| GI:21735580 | RefSeq | XP_001160139.2 | 856 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X2 [Pan troglodytes] |
| GI:21735582 | RefSeq | XP_001160055.2 | 851 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X3 [Pan troglodytes] |
| GI:21735584 | RefSeq | XP_001160009.2 | 820 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X4 [Pan troglodytes] |
| GI:21735584 | RefSeq | XP_003807973.1 | 851 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X3 [Pan paniscus] |
| GI:21735582 | RefSeq | XP_005249755.1 | 887 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Homo sapiens] |
| GI:14149704 | RefSeq | XP_009451062.1 | 887 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Pan troglodytes] |
| GI:14149704 | RefSeq | XP_009451063.1 | 887 | PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Pan troglodytes] |