Gene/Proteome Database (LMPD)

LMPD ID
LMP006767
Gene ID
9885
Species
Homo sapiens (Human)
Gene Name
oxysterol binding protein-like 2
Gene Symbol
OSBPL2
Synonyms
ORP-2; ORP2
Chromosome
20
Map Location
20q13.33
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]
Orthologs
View orthologs and multiple alignments for OSBPL2

Proteins

oxysterol-binding protein-related protein 2 isoform 1
Refseq ID NP_055650
Protein GI 7662298
UniProt ID Q9H1P3
mRNA ID NM_014835
Length 468
RefSeq Status REVIEWED
MNGEEEFFDAVTEANQKVTGMIDLDTSKNNRIGKTGERPSQENGIQKHRTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYGKWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFERNFSDCPDIY
oxysterol-binding protein-related protein 2 isoform 2
Refseq ID NP_653081
Protein GI 21450853
UniProt ID Q9H1P3
mRNA ID NM_144498
Length 480
RefSeq Status REVIEWED
MNGEEEFFDAVTGFDSDNSSGEFSEANQKVTGMIDLDTSKNNRIGKTGERPSQENGIQKHRTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYGKWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFERNFSDCPDIY
oxysterol-binding protein-related protein 2 isoform 3
Refseq ID NP_001265578
Protein GI 520975372
UniProt ID E7ET92
mRNA ID NM_001278649
Length 370
RefSeq Status REVIEWED
MPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYGKWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGSKLLWRINTRPPNSAQIWPARRRSGWRRSREKHGGSGPRRRQSGRRGGSTQAITPTLGPPTGCMQGITLSGISPTAQISTEGLEGPGARDRRLTRLDFLEWPL

Gene Information

Entrez Gene ID
9885
Gene Name
oxysterol binding protein-like 2
Gene Symbol
OSBPL2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0015485 IDA:BHF-UCL F cholesterol binding
GO:0006869 IEA:UniProtKB-KW P lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site

UniProt Annotations

Entry Information

Gene Name
oxysterol binding protein-like 2
Protein Entry
OSBL2_HUMAN
UniProt ID
Q9H1P3
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H1P3-1; Sequence=Displayed; Name=2; IsoId=Q9H1P3-2; Sequence=VSP_003781;
Function Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate.
Sequence Caution Sequence=BAA34492.2; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the OSBP family.
Tissue Specificity Widely expressed.

Identical and Related Proteins

Unique RefSeq proteins for LMP006767 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7662298 RefSeq NP_055650 468 oxysterol-binding protein-related protein 2 isoform 1
21450853 RefSeq NP_653081 480 oxysterol-binding protein-related protein 2 isoform 2
520975372 RefSeq NP_001265578 370 oxysterol-binding protein-related protein 2 isoform 3

Identical Sequences to LMP006767 proteins

Reference Database Accession Length Protein Name
GI:7662298 DBBJ BAF84540.1 468 unnamed protein product [Homo sapiens]
GI:7662298 DBBJ BAG72669.1 468 oxysterol binding protein-like 2, partial [synthetic construct]
GI:21450853 EMBL CAG33003.1 480 OSBPL2 [Homo sapiens]
GI:7662298 GenBank AAK18044.1 468 oxysterol-binding protein-related protein 2 [Homo sapiens]
GI:7662298 GenBank EAW75377.1 468 oxysterol binding protein-like 2, isoform CRA_a [Homo sapiens]
GI:21450853 GenBank EAW75379.1 480 oxysterol binding protein-like 2, isoform CRA_c [Homo sapiens]
GI:21450853 GenBank ABM82322.1 480 oxysterol binding protein-like 2 [synthetic construct]
GI:21450853 GenBank ABM85501.1 480 oxysterol binding protein-like 2, partial [synthetic construct]
GI:21450853 GenBank AIC50456.1 480 OSBPL2, partial [synthetic construct]
GI:21450853 SwissProt Q9H1P3.1 480 RecName: Full=Oxysterol-binding protein-related protein 2; Short=ORP-2; Short=OSBP-related protein 2 [Homo sapiens]

Related Sequences to LMP006767 proteins

Reference Database Accession Length Protein Name
GI:7662298 DBBJ BAA34492.2 469 KIAA0772 protein, partial [Homo sapiens]
GI:520975372 DBBJ BAF84540.1 468 unnamed protein product [Homo sapiens]
GI:520975372 DBBJ BAG59210.1 370 unnamed protein product [Homo sapiens]
GI:520975372 DBBJ BAG72669.1 468 oxysterol binding protein-like 2, partial [synthetic construct]
GI:7662298 EMBL CAG33003.1 480 OSBPL2 [Homo sapiens]
GI:7662298 GenBank AAH00296.1 480 Oxysterol binding protein-like 2 [Homo sapiens]
GI:7662298 GenBank AAH04455.1 480 Oxysterol binding protein-like 2 [Homo sapiens]
GI:520975372 GenBank AAK18044.1 468 oxysterol-binding protein-related protein 2 [Homo sapiens]
GI:520975372 GenBank EAW75377.1 468 oxysterol binding protein-like 2, isoform CRA_a [Homo sapiens]
GI:21450853 GenBank JAA11841.1 480 oxysterol binding protein-like 2 [Pan troglodytes]
GI:21450853 GenBank JAA25268.1 480 oxysterol binding protein-like 2 [Pan troglodytes]
GI:21450853 GenBank JAA39440.1 480 oxysterol binding protein-like 2 [Pan troglodytes]
GI:520975372 RefSeq NP_055650.1 468 oxysterol-binding protein-related protein 2 isoform 1 [Homo sapiens]
GI:21450853 RefSeq XP_001144767.1 480 PREDICTED: oxysterol-binding protein-related protein 2 [Pan troglodytes]
GI:7662298 RefSeq XP_002830544.1 468 PREDICTED: oxysterol-binding protein-related protein 2 isoform X2 [Pongo abelii]
GI:21450853 RefSeq XP_003281568.1 480 PREDICTED: oxysterol-binding protein-related protein 2 isoform 1 [Nomascus leucogenys]
GI:21450853 RefSeq XP_003810870.1 480 PREDICTED: oxysterol-binding protein-related protein 2 isoform X1 [Pan paniscus]
GI:7662298 RefSeq XP_004062535.1 468 PREDICTED: oxysterol-binding protein-related protein 2 isoform 2 [Gorilla gorilla gorilla]