Gene/Proteome Database (LMPD)

LMPD ID
LMP006781
Gene ID
127018
Species
Homo sapiens (Human)
Gene Name
lysophospholipase-like 1
Gene Symbol
LYPLAL1
Synonyms
Q96AV0
Chromosome
1
Map Location
1q41
EC Number
3.1.2.-

Proteins

lysophospholipase-like protein 1 isoform a
Refseq ID NP_620149
Protein GI 663429515
UniProt ID Q5VWZ2
mRNA ID NM_138794
Length 237
RefSeq Status VALIDATED
MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEMEKQK
lysophospholipase-like protein 1 isoform b
Refseq ID NP_001287698
Protein GI 663429552
UniProt ID Q5VWZ2
mRNA ID NM_001300769
Length 186
RefSeq Status VALIDATED
MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPTAPPSMFLFLGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEMEKQK
lysophospholipase-like protein 1 isoform c
Refseq ID NP_001287699
Protein GI 663429546
UniProt ID Q5VWZ2
mRNA ID NM_001300770
Length 221
RefSeq Status VALIDATED
MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPTAPPRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEMEKQK
lysophospholipase-like protein 1 isoform d
Refseq ID NP_001287701
Protein GI 663429558
UniProt ID Q5VWZ2
mRNA ID NM_001300772
Length 199
RefSeq Status VALIDATED
MWIKQVLNQDLTFQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEMEKQK
lysophospholipase-like protein 1 isoform d
Refseq ID NP_001287700
Protein GI 663429569
UniProt ID Q5VWZ2
mRNA ID NM_001300771
Length 199
RefSeq Status VALIDATED
Protein sequence is identical to GI:663429558 (mRNA isoform)

Gene Information

Entrez Gene ID
127018
Gene Name
lysophospholipase-like 1
Gene Symbol
LYPLAL1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0004622 NAS:UniProtKB F lysophospholipase activity
GO:0042997 IEA:Ensembl P negative regulation of Golgi to plasma membrane protein transport
GO:0002084 IEA:Ensembl P protein depalmitoylation

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR003140 Phospholipase/carboxylesterase/thioesterase

UniProt Annotations

Entry Information

Gene Name
lysophospholipase-like 1
Protein Entry
Q5VWZ2_HUMAN
UniProt ID
Q5VWZ2
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5VWZ2-1; Sequence=Displayed; Name=2; IsoId=Q5VWZ2-2; Sequence=VSP_017556; Note=May be due to a competing acceptor splice site. No experimental confirmation available.;
Catalytic Activity Palmitoyl-protein + H(2)O = palmitate + protein.
Function Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.
Similarity Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
Subcellular Location Isoform 1: Cytoplasm, cytosol .
Subcellular Location Isoform 2: Cytoplasm, cytosol .

Identical and Related Proteins

Unique RefSeq proteins for LMP006781 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
663429515 RefSeq NP_620149 237 lysophospholipase-like protein 1 isoform a
663429552 RefSeq NP_001287698 186 lysophospholipase-like protein 1 isoform b
663429546 RefSeq NP_001287699 221 lysophospholipase-like protein 1 isoform c
663429558 RefSeq NP_001287701 199 lysophospholipase-like protein 1 isoform d

Identical Sequences to LMP006781 proteins

Reference Database Accession Length Protein Name
GI:663429558 RefSeq XP_005273106.1 199 PREDICTED: lysophospholipase-like protein 1 isoform X4 [Homo sapiens]
GI:663429558 RefSeq NP_001287700.1 199 lysophospholipase-like protein 1 isoform d [Homo sapiens]
GI:663429515 SwissProt Q5VWZ2.3 237 RecName: Full=Lysophospholipase-like protein 1 [Homo sapiens]

Related Sequences to LMP006781 proteins

Reference Database Accession Length Protein Name
GI:663429558 DBBJ BAK62518.1 237 lysophospholipase-like protein 1 [Pan troglodytes]
GI:663429515 DBBJ BAK62518.1 237 lysophospholipase-like protein 1 [Pan troglodytes]
GI:663429515 EMBL CAJ42731.1 237 unnamed protein product [Homo sapiens]
GI:663429546 GenBank AAQ17077.1 221 lysophospholipase-like 1 [Homo sapiens]
GI:663429552 GenBank EAW93320.1 221 lysophospholipase-like 1, isoform CRA_b [Homo sapiens]
GI:663429546 GenBank EAW93320.1 221 lysophospholipase-like 1, isoform CRA_b [Homo sapiens]
GI:663429515 GenBank EAW93322.1 237 lysophospholipase-like 1, isoform CRA_d [Homo sapiens]
GI:663429515 GenBank JAA36616.1 237 lysophospholipase-like 1 [Pan troglodytes]
GI:663429558 GenBank JAA36616.1 237 lysophospholipase-like 1 [Pan troglodytes]
GI:663429515 GenBank AHD78530.1 237 Sequence 26528 from patent US 8586006
GI:663429558 GenBank AHD78530.1 237 Sequence 26528 from patent US 8586006
GI:663429546 RefSeq XP_003265135.1 221 PREDICTED: lysophospholipase-like protein 1 isoform 2 [Nomascus leucogenys]
GI:663429558 RefSeq NP_001233304.1 237 lysophospholipase-like protein 1 [Pan troglodytes]
GI:663429515 RefSeq NP_001233304.1 237 lysophospholipase-like protein 1 [Pan troglodytes]
GI:663429546 RefSeq XP_003814179.1 221 PREDICTED: lysophospholipase-like protein 1 isoform X2 [Pan paniscus]
GI:663429546 RefSeq XP_006711225.1 230 PREDICTED: lysophospholipase-like protein 1 isoform X5 [Homo sapiens]
GI:663429552 RefSeq XP_006711225.1 230 PREDICTED: lysophospholipase-like protein 1 isoform X5 [Homo sapiens]
GI:663429558 RefSeq NP_620149.2 237 lysophospholipase-like protein 1 isoform a [Homo sapiens]
GI:663429552 RefSeq NP_001287699.1 221 lysophospholipase-like protein 1 isoform c [Homo sapiens]
GI:663429552 RefSeq XP_009235819.1 186 PREDICTED: lysophospholipase-like protein 1 isoform X4 [Pongo abelii]
GI:663429546 RefSeq XP_009439622.1 221 PREDICTED: lysophospholipase-like protein 1 isoform X4 [Pan troglodytes]
GI:663429552 RefSeq XP_009439622.1 221 PREDICTED: lysophospholipase-like protein 1 isoform X4 [Pan troglodytes]
GI:663429552 RefSeq XP_009439625.1 195 PREDICTED: lysophospholipase-like protein 1 isoform X7 [Pan troglodytes]
GI:663429558 SwissProt Q5VWZ2.3 237 RecName: Full=Lysophospholipase-like protein 1 [Homo sapiens]