Gene/Proteome Database (LMPD)
Proteins
type 2C protein phosphatase PTC5 | |
---|---|
Refseq ID | NP_014733 |
Protein GI | 6324664 |
UniProt ID | Q12511 |
mRNA ID | NM_001183509 |
Length | 572 |
MSPLTRTVAIKKTVKVLSKCQSGREYTQKFLQRAYSTSHANSTYYSRTKLFISSHSKALNIALLSGSLLLTYSYYSPKKILSLDTINGIKDYSTNTSGNINMPSPNPKGTETQKSQRSQNDQSVLILNDSKIEAKLHDREESHFVNRGTGIFRYDVAQLPSNHPIEDDHVEQIITIPIESEDGKSIEKDLYFFGIFDGHGGPFTSEKLSKDLVRYVAYQLGQVYDQNKTVFHSDPNQLIDSAISKGFLKLDNDLVIESFRKLFQDPNNTNIANTLPAISGSCALLSLYNSTNSILKVAVTGDSRALICGLDNEGNWTVKSLSTDQTGDNLDEVRRIRKEHPGEPNVIRNGRILGSLQPSRAFGDYRYKIKEVDGKPLSDLPEVAKLYFRREPRDFKTPPYVTAEPVITSAKIGENTKFMVMGSDGLFELLTNEEIASLVIRWMDKNMNLAPVKAEPGKLPKVIDVSEDKEAQRPAFRYKDNNSSSPSGSNPEYLIEDKNVATHLIRNALSAGGRKEYVSALVSIPSPMSRRYRDDLTVTVAFFGDSGTPSIVSNATSIVMNPEATTKPKPRL |
Gene Information
Entrez Gene ID
Gene Name
type 2C protein phosphatase PTC5
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005758 | IDA:SGD | C | mitochondrial intermembrane space |
GO:0005739 | IDA:SGD | C | mitochondrion |
GO:0004741 | ISS:SGD | F | [pyruvate dehydrogenase (lipoamide)] phosphatase activity |
GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
GO:0004722 | IDA:SGD | F | protein serine/threonine phosphatase activity |
GO:0043085 | IMP:SGD | P | positive regulation of catalytic activity |
GO:0006470 | IDA:SGD | P | protein dephosphorylation |
GO:0050790 | IMP:SGD | P | regulation of catalytic activity |
Domain Information
UniProt Annotations
Entry Information
Gene Name
type 2C protein phosphatase PTC5
Protein Entry
PDP1_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
Comment Type | Description |
---|---|
Catalytic Activity | [Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate. |
Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 magnesium or manganese ions per subunit. ; |
Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250}; |
Function | Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex. {ECO:0000269|PubMed:16643908, ECO:0000269|PubMed:18180296}. |
Miscellaneous | Present with 7550 molecules/cell in log phase SD medium |
Miscellaneous | Present with 7550 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
Ptm | Processed by mitochondrial inner membrane protease (IMP) complex and released to the intermembrane space. |
Similarity | Belongs to the PP2C family |
Similarity | Belongs to the PP2C family. {ECO:0000305}. |
Similarity | Contains 1 PP2C-like domain |
Similarity | Contains 1 PP2C-like domain. {ECO:0000305}. |
Subcellular Location | Mitochondrion intermembrane space {ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16643908, ECO:0000269|PubMed:22984289}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006987 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
6324664 | RefSeq | NP_014733 | 572 | type 2C protein phosphatase PTC5 |
Identical Sequences to LMP006987 proteins
Reference | Database | Accession | Length | Protein Name |
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Related Sequences to LMP006987 proteins
Reference | Database | Accession | Length | Protein Name |
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