Gene/Proteome Database (LMPD)

LMPD ID
LMP006987
Gene ID
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
type 2C protein phosphatase PTC5
Gene Symbol
Synonyms
PPP1
Chromosome
XV
EC Number
3.1.3.43

Proteins

type 2C protein phosphatase PTC5
Refseq ID NP_014733
Protein GI 6324664
UniProt ID Q12511
mRNA ID NM_001183509
Length 572
MSPLTRTVAIKKTVKVLSKCQSGREYTQKFLQRAYSTSHANSTYYSRTKLFISSHSKALNIALLSGSLLLTYSYYSPKKILSLDTINGIKDYSTNTSGNINMPSPNPKGTETQKSQRSQNDQSVLILNDSKIEAKLHDREESHFVNRGTGIFRYDVAQLPSNHPIEDDHVEQIITIPIESEDGKSIEKDLYFFGIFDGHGGPFTSEKLSKDLVRYVAYQLGQVYDQNKTVFHSDPNQLIDSAISKGFLKLDNDLVIESFRKLFQDPNNTNIANTLPAISGSCALLSLYNSTNSILKVAVTGDSRALICGLDNEGNWTVKSLSTDQTGDNLDEVRRIRKEHPGEPNVIRNGRILGSLQPSRAFGDYRYKIKEVDGKPLSDLPEVAKLYFRREPRDFKTPPYVTAEPVITSAKIGENTKFMVMGSDGLFELLTNEEIASLVIRWMDKNMNLAPVKAEPGKLPKVIDVSEDKEAQRPAFRYKDNNSSSPSGSNPEYLIEDKNVATHLIRNALSAGGRKEYVSALVSIPSPMSRRYRDDLTVTVAFFGDSGTPSIVSNATSIVMNPEATTKPKPRL

Gene Information

Entrez Gene ID
Gene Name
type 2C protein phosphatase PTC5
Gene Symbol
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005758 IDA:SGD C mitochondrial intermembrane space
GO:0005739 IDA:SGD C mitochondrion
GO:0004741 ISS:SGD F [pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004722 IDA:SGD F protein serine/threonine phosphatase activity
GO:0043085 IMP:SGD P positive regulation of catalytic activity
GO:0006470 IDA:SGD P protein dephosphorylation
GO:0050790 IMP:SGD P regulation of catalytic activity

Domain Information

InterPro Annotations

Accession Description
IPR015655 Protein phosphatase 2C
IPR001932 Protein phosphatase 2C (PP2C)-like domain
IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site

UniProt Annotations

Entry Information

Gene Name
type 2C protein phosphatase PTC5
Protein Entry
PDP1_YEAST
UniProt ID
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity [Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 magnesium or manganese ions per subunit. ;
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
Function Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex. {ECO:0000269|PubMed:16643908, ECO:0000269|PubMed:18180296}.
Miscellaneous Present with 7550 molecules/cell in log phase SD medium
Miscellaneous Present with 7550 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Ptm Processed by mitochondrial inner membrane protease (IMP) complex and released to the intermembrane space.
Similarity Belongs to the PP2C family
Similarity Belongs to the PP2C family. {ECO:0000305}.
Similarity Contains 1 PP2C-like domain
Similarity Contains 1 PP2C-like domain. {ECO:0000305}.
Subcellular Location Mitochondrion intermembrane space {ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16643908, ECO:0000269|PubMed:22984289}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006987 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324664 RefSeq NP_014733 572 type 2C protein phosphatase PTC5

Identical Sequences to LMP006987 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006987 proteins

Reference Database Accession Length Protein Name