Gene/Proteome Database (LMPD)

LMPD ID
LMP007044
Gene ID
854190
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Hst3p
Gene Symbol
HST3
Synonyms
-
Alternate Names
Hst3p
Chromosome
XV
EC Number
3.5.1.-

Proteins

Hst3p
Refseq ID NP_014668
Protein GI 6324599
UniProt ID P53687
mRNA ID NM_001183444
Length 447
RefSeq Status PROVISIONAL
MTSVSPSPPASRSGSMCSDLPSSLQTEKLAHIIGLDADDEVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELPLCPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKKLSKKIHDRGGLIILVNKTPIGESSWHGIIDYQIHSDCDNWVTFLESQIPDFFKTQDQIKKLRQLKREASDLRKQMKAQKDSIGTPPTTPLRTAQGIDIQGNNELNTKIKSLNTVKRKILSPENSSEEDEEENLDTRKRAKIRPTFGDNQAS

Gene Information

Entrez Gene ID
854190
Gene Name
Hst3p
Gene Symbol
HST3
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IC:SGD C nucleus
GO:0003677 ISS:SGD F DNA binding
GO:0070403 IEA:InterPro F NAD+ binding
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006348 IGI:SGD P chromatin silencing at telomere
GO:0016575 IMP:SGD P histone deacetylation
GO:0046459 IMP:SGD P short-chain fatty acid metabolic process
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
sce01100 Metabolic pathways
ko00760 Nicotinate and nicotinamide metabolism
sce00760 Nicotinate and nicotinamide metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029035 DHS-like NAD/FAD-binding domain
IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR026591 Sirtuin family, catalytic core small domain

UniProt Annotations

Entry Information

Gene Name
Hst3p
Protein Entry
HST3_YEAST
UniProt ID
P53687
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity NAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein. {ECO:0000255|PROSITE- ProRule:PRU00236}.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
Function NAD-dependent histone deacetylase, which contributes together with HST4 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance. {ECO:0000269|PubMed:10841563, ECO:0000269|PubMed:16487579, ECO:0000269|PubMed:16815704, ECO:0000269|PubMed:17106263}.
Miscellaneous Present with 319 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the sirtuin family. Class I subfamily. {ECO:0000305}.
Similarity Contains 1 deacetylase sirtuin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00236}.
Subcellular Location Cytoplasm. Nucleus.

Identical and Related Proteins

Unique RefSeq proteins for LMP007044 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324599 RefSeq NP_014668 447 Hst3p

Identical Sequences to LMP007044 proteins

Reference Database Accession Length Protein Name
GI:6324599 EMBL CAA60741.1 447 ORF OR26.15 [Saccharomyces cerevisiae]
GI:6324599 EMBL CAA99215.1 447 HST3 [Saccharomyces cerevisiae]
GI:6324599 GenBank AAA81034.1 447 Hst3p [Saccharomyces cerevisiae]
GI:6324599 GenBank AAV20465.1 447 Sequence 725 from patent US 6753314
GI:6324599 SwissProt P53687.1 447 RecName: Full=NAD-dependent histone deacetylase HST3; AltName: Full=Homologous to SIR2 protein 3; AltName: Full=Regulatory protein SIR2 homolog 3 [Saccharomyces cerevisiae S288c]
GI:6324599 Third Party Genbank DAA10807.1 447 TPA: Hst3p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007044 proteins

Reference Database Accession Length Protein Name
GI:6324599 DBBJ GAA26349.1 447 K7_Hst3p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6324599 GenBank AAU09783.1 447 YOR025W [Saccharomyces cerevisiae]
GI:6324599 GenBank EDN63894.1 447 conserved protein [Saccharomyces cerevisiae YJM789]
GI:6324599 GenBank EDZ69368.1 447 YOR025Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:6324599 GenBank EGA73144.1 447 Hst3p [Saccharomyces cerevisiae AWRI796]
GI:6324599 GenBank EHN04796.1 447 Hst3p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]