LIPID MAPS

LMPD ID

LMP007147

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Hst4p

Gene Symbol

HST4

Synonyms

-

Chromosome

IV

EC Number

3.5.1.-

Hst4p
Refseq ID	NP_010477
Protein GI	398366029
UniProt ID	P53688
mRNA ID	NM_001180499
Length	370
MKQKFVLPITPPSTAEKKPQTENRCNENLKPRRLLPQLKKSVRNRKPRLSYRPELNSVFDLDAYVDSTHLSKSQRHHMDRDAGFISYALNYSKRMVVVSGAGISVAAGIPDFRSSEGIFSTVNGGSGKDLFDYNRVYGDESMSLKFNQLMVSLFRLSKNCQPTKFHEMLNEFARDGRLLRLYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKPFDPELFKCDDKFDSRTEIIPSCPQCEEYETVRKMAGLRSTGVGKLRPRVILYNEVHPEGDFIGEIANNDLKKRIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGIVLYLNTSMPPKNVLDSLKFVDLVVLGDCQHVTSLL

Entrez Gene ID

Gene Name

Hst4p

Gene Symbol

HST4

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0003677	ISS:SGD	F	DNA binding
GO:0070403	IEA:InterPro	F	NAD+ binding
GO:0016787	IEA:UniProtKB-KW	F	hydrolase activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0006348	IGI:SGD	P	chromatin silencing at telomere
GO:0016575	IMP:SGD	P	histone deacetylation
GO:0046459	IMP:SGD	P	short-chain fatty acid metabolic process
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated

KEGG Pathway ID	Description
sce01100	Metabolic pathways
ko00760	Nicotinate and nicotinamide metabolism
sce00760	Nicotinate and nicotinamide metabolism

Accession	Description
IPR029035	DHS-like NAD/FAD-binding domain
IPR003000	Sirtuin family
IPR026590	Sirtuin family, catalytic core domain
IPR026591	Sirtuin family, catalytic core small domain

Gene Name

Hst4p

Protein Entry

HST4_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	NAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein. {ECO:0000255\|PROSITE- ProRule:PRU00236}.
Cofactor	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 1 zinc ion per subunit. ;
Cofactor	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
Function	NAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance. {ECO:0000269\|PubMed:10841563, ECO:0000269\|PubMed:16487579, ECO:0000269\|PubMed:16815704, ECO:0000269\|PubMed:17106263}.
Miscellaneous	Present with 377 molecules/cell in log phase SD medium
Miscellaneous	Present with 377 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the sirtuin family. Class I subfamily
Similarity	Belongs to the sirtuin family. Class I subfamily. {ECO:0000305}.
Similarity	Contains 1 deacetylase sirtuin-type domain
Similarity	Contains 1 deacetylase sirtuin-type domain. {ECO:0000255\|PROSITE-ProRule:PRU00236}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:17106263}.