LIPID MAPS

LMPD ID

LMP007298

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Plb3p

Gene Symbol

PLB3

Synonyms

-

Chromosome

XV

EC Number

3.1.1.5

Plb3p
Refseq ID	NP_014632
Protein GI	6324563
UniProt ID	Q08108
mRNA ID	NM_001183265
Length	686
MIRPLCSKIIISYIFAISQFLLAANAWSPTDSYVPGTVSCPDDINLVREATSISQNESAWLEKRNKVTSVALKDFLTRATANFSDSSEVLSKLFNDGNSENLPKIAVAVSGGGYRSMLTGAGVLAAMDNRTEGAYEHGLGGLLQSTTYLSGASGGNWLVGTLALNNWTSVQDILNNMQNDDSIWDLSDSIVTPGGINIFKTAKRWDHISNAVESKQNADYNTSLADIWGRALAYNFFPSLNRGGIGLTWSSIRDFPVFQNAEMPFPISVADGRYPGTKVINLNATVFEFNPFEMGSWDPSLNSFANVKYLGTNVSNGVPLERGKCTAGFDNAGFIMGTSSTLFNQFLLRINSTHLPSFITRLARHFLKDLSQDFNDIAVYSPNPFKDTKFLDSDYTTSIVDSDSLFLVDGGEDDENVPVLPLIQKERDVDIIFAVDNSADMRLAWPDGSSLVHTYERQFVKQGQGMSFPYVPDTNTFVNLGLNKKPTFFGCDANNLTDLQYIPPLVVYLPNAEYSFNSNQSAFKLSYSESQRRSMIQNGFEIATRNNFTDDPEFMGCVGCAIIRRKQQALNITLPPECETCFKNYCWNGTLDTTPLPDVEKDVHHSFINVNSFNSSIGQEESLYAGSSASQSSSSSSSSSSSSEIPSATATLEKKAATNSGSHLSGISVKFSAMIMLTLLMFTGAV

Entrez Gene ID

Gene Name

Plb3p

Gene Symbol

PLB3

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0031225	IEA:UniProtKB-KW	C	anchored component of membrane
GO:0005576	IDA:SGD	C	extracellular region
GO:0005886	ISS:SGD	C	plasma membrane
GO:0004622	IMP:SGD	F	lysophospholipase activity
GO:0046488	IDA:SGD	P	phosphatidylinositol metabolic process
GO:0006660	IDA:SGD	P	phosphatidylserine catabolic process

KEGG Pathway ID	Description
ko00564	Glycerophospholipid metabolism
sce00564	Glycerophospholipid metabolism

Accession	Description
IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
IPR002642	Lysophospholipase, catalytic domain

Gene Name

Plb3p

Protein Entry

PLB3_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Function	Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate
Function	Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate. {ECO:0000269\|PubMed:10497163}.
Similarity	Belongs to the lysophospholipase family
Similarity	Belongs to the lysophospholipase family. {ECO:0000305}.
Similarity	Contains 1 PLA2c domain. {ECO:0000255\|PROSITE- ProRule:PRU00555}.
Subcellular Location	Cell membrane ; Lipid-anchor, GPI-anchor .
Subcellular Location	Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.