Gene/Proteome Database (LMPD)

LMPD ID
LMP007423
Gene ID
854289
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
profilin
Gene Symbol
PFY1
Synonyms
CLS5; PRF1
Chromosome
XV

Proteins

profilin
Refseq ID NP_014765
Protein GI 398365245
UniProt ID P07274
mRNA ID NM_001183541
Length 126
MSWQAYTDNLIGTGKVDKAVIYSRAGDAVWATSGGLSLQPNEIGEIVQGFDNPAGLQSNGLHIQGQKFMLLRADDRSIYGRHDAEGVVCVRTKQTVIIAHYPPTVQAGEATKIVEQLADYLIGVQY

Gene Information

Entrez Gene ID
854289
Gene Name
profilin
Gene Symbol
PFY1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005856 IEA:UniProtKB-KW C cytoskeleton
GO:0005829 IDA:SGD C cytosol
GO:0019897 IDA:SGD C extrinsic component of plasma membrane
GO:0003785 IDA:SGD F actin monomer binding
GO:0005546 IDA:SGD F phosphatidylinositol-4,5-bisphosphate binding
GO:0070064 IDA:SGD F proline-rich region binding
GO:0030036 IEA:InterPro P actin cytoskeleton organization
GO:0046907 IGI:SGD P intracellular transport
GO:0090338 IDA:SGD P positive regulation of formin-nucleated actin cable assembly
GO:0042989 IDA:SGD P sequestering of actin monomers

Domain Information

InterPro Annotations

Accession Description
IPR005455 PFN
IPR027310 Profilin_CS

UniProt Annotations

Entry Information

Gene Name
profilin
Protein Entry
PROF_YEAST
UniProt ID
P07274
Species
Yeast (S288c)

Comments

Comment Type Description
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Interaction Q9VEX9:Bin1 (xeno); NbExp=3; IntAct=EBI-13892, EBI-129424;
Similarity Belongs to the profilin family
Similarity Belongs to the profilin family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytoskeleton.
Subunit Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Identical and Related Proteins

Unique RefSeq proteins for LMP007423 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365245 RefSeq NP_014765 126 profilin

Identical Sequences to LMP007423 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007423 proteins

Reference Database Accession Length Protein Name