LIPID MAPS

LMPD ID

LMP007448

Gene ID

852924

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Cax4p

Gene Symbol

CAX4

Synonyms

CWH8

Chromosome

VII

EC Number

3.6.1.43

Cax4p
Refseq ID	NP_011550
Protein GI	398365285
UniProt ID	P53223
mRNA ID	NM_001181165
Length	239
MNSTAAAINPNPNVIPFDDTYILYDSHDFLSFLSAYFSLMPILVLAFYLSWFIITRELEACIVAFGQLMNEIFNNVIKNIIKQPRPVSFGASFQNDTIRSGYGMPSAHSQFMGFCFTYNSLKIYTSWKNLNFLEKCIFSGALALLSFCVCFSRVYLHYHNLDQVIVGFSVGALTGSLYFFIVGIIRELGLINWFLKLRIVRLFYMTDSYNLAPLTLKENYEAYWKRINQRSFNDKSKRD

Entrez Gene ID

852924

Gene Name

Cax4p

Gene Symbol

CAX4

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030176	IDA:SGD	C	integral component of endoplasmic reticulum membrane
GO:0047874	IDA:SGD	F	dolichyldiphosphatase activity
GO:0008610	IMP:SGD	P	lipid biosynthetic process
GO:0006487	IMP:SGD	P	protein N-linked glycosylation

KEGG Pathway Links

KEGG Pathway ID	Description
ko00510	N-Glycan biosynthesis
sce00510	N-Glycan biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618350	Asparagine N-linked glycosylation
5618349	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5618074	Metabolism of proteins
5618285	Post-translational protein modification
5618347	Synthesis of Dolichyl-phosphate
5618348	Synthesis of substrates in N-glycan biosythesis

InterPro Annotations

Accession	Description
IPR000326	Phosphatidic acid phosphatase type 2/haloperoxidase

Entry Information

Gene Name

Cax4p

Protein Entry

CAX4_YEAST

UniProt ID

P53223

Species

Yeast (S288c)

Comments

Comment Type	Description
Biophysicochemical Properties	pH dependence: Optimum pH is 6-7.;
Biophysicochemical Properties	pH dependence: Optimum pH is 6-7.;
Catalytic Activity	Dolichyl diphosphate + H(2)O = dolichyl phosphate + phosphate.
Function	Non-essential protein which is required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate
Function	Non-essential protein which is required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. {ECO:0000269\|PubMed:10024662, ECO:0000269\|PubMed:11504728}.
Interaction	Self; NbExp=1; IntAct=EBI-23136, EBI-23136; P25376:AGP1; NbExp=1; IntAct=EBI-23136, EBI-2357; P38242:ALG14; NbExp=1; IntAct=EBI-23136, EBI-21477; P08456:CHO1; NbExp=1; IntAct=EBI-23136, EBI-14055; P40975:PMP2; NbExp=1; IntAct=EBI-23136, EBI-2043041; P39986:SPF1; NbExp=1; IntAct=EBI-23136, EBI-3128;
Pathway	Protein modification; protein glycosylation.
Similarity	Belongs to the dolichyldiphosphatase family
Similarity	Belongs to the dolichyldiphosphatase family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:11504728}; Multi-pass membrane protein {ECO:0000269\|PubMed:11504728}.