LIPID MAPS

LMPD ID

LMP007472

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

4-hydroxybenzoate octaprenyltransferase

Gene Symbol

COQ2

Synonyms

-

Chromosome

XIV

EC Number

2.5.1.39

4-hydroxybenzoate octaprenyltransferase
Refseq ID	NP_014439
Protein GI	398365767
UniProt ID	P32378
mRNA ID	NM_001183218
Length	372
MFIWQRKSILLGRSILGSGRVTVAGIIGSSRKRYTSSSSSSSSPSSKESAPVFTSKELEVARKERLDGLGPFVSRLPKKWIPYAELMRLEKPVGTWLLYLPCSWSILMGAMMQGATLSATAGMLGIFGVGALVMRGAGCTINDFLDRKLDQRVIRSVERPIASGRVSPRRALVFLGAQTLVGMGVLSLLPAQCWWLGLASLPIVFTYPLFKRFTYYPQAALSACFNWGALLGFPAMGVMSWPTMIPLYLSSYLWCMTYDTIYAHQDKKFDIKAGIKSTALAWGPRTKSIMKAMSASQIALLAVAGLNSGLLWGPGFIGGLGVFAYRLFSMIKKVDLDNPKNCWKYFNANINTGLYFTYALAVDYILRLFGFL

Entrez Gene ID

Gene Name

4-hydroxybenzoate octaprenyltransferase

Gene Symbol

COQ2

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0032592	IDA:SGD	C	integral component of mitochondrial membrane
GO:0005743	TAS:Reactome	C	mitochondrial inner membrane
GO:0005758	TAS:Reactome	C	mitochondrial intermembrane space
GO:0005739	IDA:SGD	C	mitochondrion
GO:0002083	IEA:UniProtKB-EC	F	4-hydroxybenzoate decaprenyltransferase activity
GO:0047293	IEA:UniProtKB-EC	F	4-hydroxybenzoate nonaprenyltransferase activity
GO:0008412	IMP:SGD	F	4-hydroxybenzoate octaprenyltransferase activity
GO:0008299	IEA:UniProtKB-KW	P	isoprenoid biosynthetic process
GO:0006744	IMP:SGD	P	ubiquinone biosynthetic process

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
sce01100	Metabolic pathways
ko00130	Ubiquinone and other terpenoid-quinone biosynthesis
sce00130	Ubiquinone and other terpenoid-quinone biosynthesis
M00128	Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone
sce_M00128	Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone

BIOCYC Pathway ID	Description
ALL-CHORISMATE-YEAST-PWY	superpathway of chorismate metabolism
PWY-7235	superpathway of ubiquinol-6 biosynthesis
PWY-7235	superpathway of ubiquinol-6 biosynthesis (eukaryotic)
PWY-7230	ubiquinol-6 biosynthesis from 4-aminobenzoate
PWY-7230	ubiquinol-6 biosynthesis from 4-aminobenzoate (eukaryotic)
PWY3O-19	ubiquinol-6 biosynthesis from 4-hydroxybenzoate (eukaryotic)
PWY3O-19	ubiquinol-6 biosynthesis from 4-hydroxybenzoate (eukaryotic)
PWY-7233	ubiquinol-6 bypass biosynthesis
PWY-7233	ubiquinol-6 bypass biosynthesis (eukaryotic)

REACTOME Pathway ID	Description
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618074	Metabolism of proteins
5618585	Mitochondrial protein import
5618642	Ubiquinol biosynthesis

Accession	Description
IPR006370	4-hydroxybenzoate polyprenyl transferase
IPR000537	UbiA prenyltransferase family

Gene Name

4-hydroxybenzoate octaprenyltransferase

Protein Entry

COQ2_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.
Function	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB (By similarity)
Function	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB (By similarity). {ECO:0000250}.
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis.
Similarity	Belongs to the UbiA prenyltransferase family
Similarity	Belongs to the UbiA prenyltransferase family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane; Multi-pass membrane protein.