Gene/Proteome Database (LMPD)
LMPD ID
LMP007621
Gene ID
Species
Escherichia coli K-12 (E. coli)
Gene Name
anaerobic sn-glycerol-3-phosphate dehydrogenase, large FAD/NAD(P)-binding subunit
Gene Symbol
Synonyms
ECK2233; JW2235
Summary
The GlpABC enzyme is loosely associated with the cell membrane. [More information is available at EcoCyc: EG10391].
Orthologs
Proteins
| anaerobic sn-glycerol-3-phosphate dehydrogenase, large FAD/NAD(P)-binding subunit [Escherichia coli str. K-12 substr. MG1655] | |
|---|---|
| Refseq ID | NP_416744 |
| Protein GI | 16130176 |
| UniProt ID | P0A9C0 |
| Length | 542 |
| RefSeq Status | REVIEWED |
| MKTRDSQSSDVIIIGGGATGAGIARDCALRGLRVILVERHDIATGATGRNHGLLHSGARYAVTDAESARECISENQILKRIARHCVEPTNGLFITLPEDDLSFQATFIRACEEAGISAEAIDPQQARIIEPAVNPALIGAVKVPDGTVDPFRLTAANMLDAKEHGAVILTAHEVTGLIREGATVCGVRVRNHLTGETQALHAPVVVNAAGIWGQHIAEYADLRIRMFPAKGSLLIMDHRINQHVINRCRKPSDADILVPGDTISLIGTTSLRIDYNEIDDNRVTAEEVDILLREGEKLAPVMAKTRILRAYSGVRPLVASDDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDAVCRKLGNTRPCTTADLALPGSQEPAEVTLRKVISLPAPLRGSAVYRHGDRTPAWLSEGRLHRSLVCECEAVTAGEVQYAVENLNVNSLLDLRRRTRVGMGTCQGELCACRAAGLLQRFNVTTSAQSIEQLSTFLNERWKGVQPIAWGDALRESEFTRWVYQGLCGLEKEQKDAL | |
Gene Information
Entrez Gene ID
Gene Name
anaerobic sn-glycerol-3-phosphate dehydrogenase, large FAD/NAD(P)-binding subunit
Gene Symbol
Species
Escherichia coli K-12
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009331 | IEA:InterPro | C | glycerol-3-phosphate dehydrogenase complex |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0010181 | IEA:InterPro | F | FMN binding |
| GO:0050660 | IDA:EcoCyc | F | flavin adenine dinucleotide binding |
| GO:0004368 | IDA:EcoCyc | F | glycerol-3-phosphate dehydrogenase activity |
| GO:0052591 | IEA:UniProtKB-EC | F | sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity |
| GO:0019563 | IEA:UniProtKB-UniPathway | P | glycerol catabolic process |
| GO:0006072 | IEA:InterPro | P | glycerol-3-phosphate metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| eco00564 | Glycerophospholipid metabolism |
| ko00564 | Glycerophospholipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY0-381 | glycerol and glycerophosphodiester degradation |
| PWY0-381 | glycerol and glycerophosphodiester degradation |
| PWY-4261 | glycerol degradation I |
| PWY0-381 | glycerol degradation I |
| PWY-4261 | glycerol degradation I |
| PWY-6952 | glycerophosphodiester degradation |
| PWY-6952 | glycerophosphodiester degradation |
Domain Information
UniProt Annotations
Entry Information
Gene Name
anaerobic sn-glycerol-3-phosphate dehydrogenase, large FAD/NAD(P)-binding subunit
Protein Entry
GLPA_ECOLI
UniProt ID
Species
E. coli
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. |
| Cofactor | Name=FAD; Xref=ChEBI:CHEBI:57692; |
| Cofactor | Name=FMN; Xref=ChEBI:CHEBI:58210; |
| Function | Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. |
| Pathway | Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1. |
| Similarity | Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}. |
| Subcellular Location | Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase. |
| Subunit | Composed of a catalytic GlpA/B dimer and of membrane bound GlpC. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007621 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 16130176 | RefSeq | NP_416744 | 542 | anaerobic sn-glycerol-3-phosphate dehydrogenase, large FAD/NAD(P)-binding subunit [Escherichia coli str. K-12 substr. MG1655] |
Identical Sequences to LMP007621 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16130176 | GenBank | KHJ04112.1 | 542 | glycerol-3-phosphate dehydrogenase [Escherichia coli] |
| GI:16130176 | GenBank | KHJ14703.1 | 542 | glycerol-3-phosphate dehydrogenase [Escherichia coli] |
| GI:16130176 | GenBank | KHJ18212.1 | 542 | glycerol-3-phosphate dehydrogenase [Escherichia coli] |
| GI:16130176 | GenBank | KHJ24256.1 | 542 | glycerol-3-phosphate dehydrogenase [Escherichia coli] |
| GI:16130176 | GenBank | KHJ26669.1 | 542 | glycerol-3-phosphate dehydrogenase [Escherichia coli] |
| GI:16130176 | gnl | IGS | 542 | sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding [Escherichia coli ER2796] |
Related Sequences to LMP007621 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16130176 | GenBank | ABC03649.1 | 542 | Sequence 16 from patent US 6953684 |
| GI:16130176 | GenBank | ABE22365.1 | 542 | Sequence 12 from patent US 7005291 |
| GI:16130176 | GenBank | EFF13558.1 | 542 | glycerol-3-phosphate dehydrogenase [Escherichia coli B354] |
| GI:16130176 | GenBank | EIG94232.1 | 542 | glycerol-3-phosphate dehydrogenase, anaerobic, A subunit [Escherichia coli 97.0246] |
| GI:16130176 | RefSeq | WP_000857232.1 | 542 | sn-glycerol-3-phosphate dehydrogenase subunit A [Escherichia coli] |
| GI:16130176 | RefSeq | WP_000857261.1 | 542 | sn-glycerol-3-phosphate dehydrogenase subunit A [Escherichia coli] |