Gene/Proteome Database (LMPD)

LMPD ID
LMP007673
Gene ID
949007
Species
Escherichia coli K-12 (E. coli)
Gene Name
acyl coenzyme A dehydrogenase
Gene Symbol
fadE
Synonyms
ECK0222; JW5020; fadF; yafH
Summary
FadR regulon. [More information is available at EcoGene: EG13145]. The previously uncharacterized yafH open reading frame has been shown to encode the FadE acyl-CoA dehydrogenase enzyme . [More information is available at EcoCyc: G6105].
Orthologs
View orthologs and multiple alignments for fadE

Proteins

acyl coenzyme A dehydrogenase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_414756
Protein GI 90111100
UniProt ID Q47146
Length 814
RefSeq Status REVIEWED
MMILSILATVVLLGALFYHRVSLFISSLILLAWTAALGVAGLWSAWVLVPLAIILVPFNFAPMRKSMISAPVFRGFRKVMPPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPRLTAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLKEHRFFAMIIKKEYGGLEFSAYAQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKDHYLPRLARGQEIPCFALTSPEAGSDAGAIPDTGIVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEKLLGGAEDLGITCALIPTTTPGVEIGRRHFPLNVPFQNGPTRGKDVFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIRRQFKISIGKMEGIEEPLARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGQSNFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMEAAKNNDVNAFDKLLFKHIGHVGSNKVRSFWLGLTRGLTSSTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGSLKRRERISARLGDILSQLYLASAVLKRYDDEGRNEADLPLVHWGVQDALYQAEQAMDDLLQNFPNRVVAGLLNVVIFPTGRHYLAPSDKLDHKVAKILQVPNATRSRIGRGQYLTPSEHNPVGLLEEALVDVIAADPIHQRICKELGKNLPFTRLDELAHNALVKGLIDKDEAAILVKAEESRLRSINVDDFDPEELATKPVKLPEKVRKVEAA

Gene Information

Entrez Gene ID
949007
Gene Name
acyl coenzyme A dehydrogenase
Gene Symbol
fadE
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0003995 IMP:EcoCyc F acyl-CoA dehydrogenase activity
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0033539 IMP:EcoCyc P fatty acid beta-oxidation using acyl-CoA dehydrogenase

KEGG Pathway Links

KEGG Pathway ID Description
eco00071 Fatty acid degradation
ko00071 Fatty acid degradation
eco01212 Fatty acid metabolism
ko01212 Fatty acid metabolism
eco01100 Metabolic pathways
M00087 beta-Oxidation
eco_M00087 beta-Oxidation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
FAO-PWY fatty acid beta-oxidation I
FAO-PWY fatty acid beta-oxidation I
FAO-PWY fatty acid beta-oxidation I

Domain Information

InterPro Annotations

Accession Description
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR015396 DUF1974

UniProt Annotations

Entry Information

Gene Name
acyl coenzyme A dehydrogenase
Protein Entry
FADE_ECOLI
UniProt ID
Q47146
Species
E. coli

Comments

Comment Type Description
Catalytic Activity An acyl-CoA + FAD = a dehydrogenated acyl-CoA + FADH(2).
Caution Was originally named fadF. {ECO:0000305}.
Function Catalyzes the dehydrogenation of acyl-CoA. {ECO:0000269|PubMed:12057976}.
Induction Negatively regulated by FadR.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Sequence Caution Sequence=BAA07583.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the acyl-CoA dehydrogenase family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007673 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
90111100 RefSeq NP_414756 814 acyl coenzyme A dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007673 proteins

Reference Database Accession Length Protein Name
GI:90111100 GenBank KHI16439.1 814 acyl-CoA dehydrogenase [Escherichia coli]
GI:90111100 GenBank KHI18473.1 814 acyl-CoA dehydrogenase [Escherichia coli]
GI:90111100 GenBank KHI62251.1 814 acyl-CoA dehydrogenase [Escherichia coli]
GI:90111100 GenBank KHI79861.1 814 acyl-CoA dehydrogenase [Escherichia coli]
GI:90111100 GenBank KHI89017.1 814 acyl-CoA dehydrogenase [Escherichia coli]
GI:90111100 gnl IGS 814 acyl coenzyme A dehydrogenase [Escherichia coli ER2796]

Related Sequences to LMP007673 proteins

Reference Database Accession Length Protein Name
GI:90111100 GenBank EGI12263.1 826 acyl-coenzyme A dehydrogenase (ACDH) [Escherichia coli H736]
GI:90111100 GenBank ESK01581.1 814 acyl-coenzyme A dehydrogenase [Escherichia coli HVH 50 (4-2593475)]
GI:90111100 gnl vbsumn 826 acyl coenzyme A dehydrogenase FadE [Escherichia coli UMNK88]
GI:90111100 RefSeq YP_006132071.1 826 acyl coenzyme A dehydrogenase FadE [Escherichia coli UMNK88]
GI:90111100 RefSeq WP_001310543.1 826 acyl-CoA dehydrogenase [Escherichia coli]
GI:90111100 RefSeq WP_001514936.1 814 acyl-coenzyme A dehydrogenase [Escherichia coli]