Gene/Proteome Database (LMPD)

LMPD ID
LMP008792
Gene ID
40988
Species
Drosophila melanogaster (Drosophila)
Gene Name
Coenzyme Q biosynthesis protein 2
Gene Symbol
Coq2
Synonyms
CG9613; coq2; COQ2; Dmel\CG9613; sbo
Alternate Names
CG9613-PA; Coq2-PA; coenzyme Q biosynthesis protein 2; small boy
Chromosome
3R
Map Location
84F11-84F11
EC Number
2.5.1.39

Proteins

coenzyme Q biosynthesis protein 2
Refseq ID NP_649789
Protein GI 21355567
UniProt ID Q9VHS7
mRNA ID NM_141532
Length 392
RefSeq Status REVIEWED
MYALRHLRLQSARHFRSSYAAAATTKHMLPRQPARVLIGDWSTWDKSRLQDVCSRSSSTATEPVKQQTPLQELVSAAKPYAQLMRIDRPIGTYLLFWPCAWSIALSADAGCWPDLTMLGLFGTGALIMRGAGCTINDLWDKDIDAKVERTRLRPLASGQISQFDAIVFLSAQLSLGLLVLVQLNWQSILLGASSLGLVITYPLMKRVTYWPQLVLGMAFNWGALLGWCATQGSVNLAACLPLYLSGVCWTIVYDTIYAHQDKLDDLQIGVKSTALRFGENTKVWLSGFTAAMLTGLSAAGWACDQTVPYYAAVGVVGAHLVQQIYSLNIDNPSDCAKKFISNHQVGLILFLGIVLGTLLKSDESKKQRQSSLTTSTASSYVPALPQKPEVLS

Gene Information

Entrez Gene ID
40988
Gene Name
Coenzyme Q biosynthesis protein 2
Gene Symbol
Coq2
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005736 ISS:UniProtKB C DNA-directed RNA polymerase I complex
GO:0005666 ISS:UniProtKB C DNA-directed RNA polymerase III complex
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005743 ISS:UniProtKB C mitochondrial inner membrane
GO:0002083 IEA:UniProtKB-EC F 4-hydroxybenzoate decaprenyltransferase activity
GO:0047293 IEA:UniProtKB-EC F 4-hydroxybenzoate nonaprenyltransferase activity
GO:0008412 ISS:UniProtKB F 4-hydroxybenzoate octaprenyltransferase activity
GO:0050829 IMP:FlyBase P defense response to Gram-negative bacterium
GO:0050830 IMP:FlyBase P defense response to Gram-positive bacterium
GO:0050832 IMP:FlyBase P defense response to fungus
GO:0008340 IDA:FlyBase P determination of adult lifespan
GO:0048009 IDA:FlyBase P insulin-like growth factor receptor signaling pathway
GO:0008299 IEA:UniProtKB-KW P isoprenoid biosynthetic process
GO:0006360 ISS:UniProtKB P transcription from RNA polymerase I promoter
GO:0006744 ISS:UniProtKB P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
dme01100 Metabolic pathways
dme00130 Ubiquinone and other terpenoid-quinone biosynthesis
dme_M00128 Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone

REACTOME Pathway Links

REACTOME Pathway ID Description
6226959 Ubiquinol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006370 4-hydroxybenzoate polyprenyl transferase
IPR000537 UbiA prenyltransferase family

UniProt Annotations

Entry Information

Gene Name
Coenzyme Q biosynthesis protein 2
Protein Entry
COQ2_DROME
UniProt ID
Q9VHS7
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.
Disruption Phenotype Flies exhibit a G1/S block in the third larval instar with normal neuronal differentiation. {ECO:0000269|PubMed:16849596}.
Function Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB (By similarity). {ECO:0000250}.
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Similarity Belongs to the UbiA prenyltransferase family. {ECO:0000305}.
Subcellular Location Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008792 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21355567 RefSeq NP_649789 392 coenzyme Q biosynthesis protein 2

Identical Sequences to LMP008792 proteins

Reference Database Accession Length Protein Name
GI:21355567 EMBL CBD21056.1 392 unnamed protein product [Drosophila melanogaster]
GI:21355567 EMBL CBD23379.1 392 unnamed protein product [Drosophila melanogaster]
GI:21355567 EMBL CBD19269.1 392 unnamed protein product [Drosophila melanogaster]
GI:21355567 EMBL CBD19592.1 392 unnamed protein product [Drosophila melanogaster]
GI:21355567 EMBL CBD23905.1 392 unnamed protein product [Drosophila melanogaster]
GI:21355567 EMBL CBD24050.1 392 unnamed protein product [Drosophila melanogaster]

Related Sequences to LMP008792 proteins

Reference Database Accession Length Protein Name
GI:21355567 GenBank EDV49938.1 392 GG17457 [Drosophila erecta]
GI:21355567 GenBank EDW96504.1 392 GE24856 [Drosophila yakuba]
GI:21355567 GenBank EDX15777.1 392 GD15120 [Drosophila simulans]
GI:21355567 RefSeq XP_001980980.1 392 GG17457 [Drosophila erecta]
GI:21355567 RefSeq XP_002096792.1 392 GE24856 [Drosophila yakuba]
GI:21355567 RefSeq XP_002076590.1 392 GD15120 [Drosophila simulans]