Gene/Proteome Database (LMPD)

LMPD ID
LMP008985
Gene ID
64880
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG5686 gene product from transcript CG5686-RB
Gene Symbol
chico
Synonyms
['anon-WO0078940.1', 'anon-WO0078940.4', 'BcDNA.GH11263', 'BcDNA:GH11263', 'CG5686', 'chic', 'Chico', 'CHICO', 'dIRS', 'Dmel\CG5686', 'fs(2)4', 'fs(2)ry4', 'IRS', 'IRS/chico']
Chromosome
2L
Map Location
31B1-31B1

Proteins

chico, isoform A
Refseq ID NP_723540
Protein GI 24583283
UniProt ID Q9XTN2
mRNA ID NM_164899
Length 968
RefSeq Status REVIEWED
Protein sequence is identical to GI:320544879 (mRNA isoform)
chico, isoform B
Refseq ID NP_001188772
Protein GI 320544879
UniProt ID Q9XTN2
mRNA ID NM_001201843
Length 968
RefSeq Status REVIEWED
MASISDDGMALSGYLKKLKTMKKKFFVLYEETSTSAARLEYYDTEKKFLQRAEPKRVIYLKNCFNINRRLDTKHRFVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQRNIANSNGTAHSPYDHVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVASIEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILSAMSAKTESNTNLINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQNSQNSLELRSCSSPHNYGFGRERCDSLPTRNGTLSESSNQTYFGSNHGLRSNTISGIRPHSTNKHSNSPTFTMPLRCSESEESSISVDESDDNGSFSHYRLNTRSSETAIPEENIDDFASAELFSKVTEQNVSDENYIPMNPVNPTDAIHEKEKADMQRLEDASLHFNFPEHASEKLAKDFDLDSDNQCCRPIRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVRAYSVGSKSKIPRCDLQRVVLVEDNKHEFTANRSQSSITKEGTSYGSSANRQKKSTSAPLLSLKNQINSDRMSDLMEIDFSQATNLEKQKFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNTAITSEDGYLEMKPVGNGYTPSSNCLPMKVEKLKLSDYQTAPPLTATAAPVHDLNKISTYNISAEKWREQPSRSEEKKSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKVCAQSSDKLNNHLADKIVENNNLDIGGHEEKKLVHSISSEDYTQIKDKSNDFTKFNEAGYKILQIKSDSSLISSKLYQKGIHKDNLERSQRLTESVNTIPDNATATAVSSSSLTKFNINSAKPAAAADSRSTGTDPSTPQNILQIKDLNFPSRSSSRISQPELHYASLDLPHCSGQNPAKYLKRGSRESPPVSACPEDGNTYAKIDFDQSDSSSSSSNIFNT
chico, isoform C
Refseq ID NP_001260316
Protein GI 442627163
UniProt ID Q9XTN2
mRNA ID NM_001273387
Length 968
RefSeq Status REVIEWED
Protein sequence is identical to GI:320544879 (mRNA isoform)

Gene Information

Entrez Gene ID
64880
Gene Name
CG5686 gene product from transcript CG5686-RB
Gene Symbol
chico
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0043231 ISS:UniProtKB C intracellular membrane-bounded organelle
GO:0005634 ISS:UniProtKB C nucleus
GO:0042169 ISS:UniProtKB F SH2 domain binding
GO:0005158 IPI:UniProtKB F insulin receptor binding
GO:0005159 ISS:UniProtKB F insulin-like growth factor receptor binding
GO:0043548 ISS:UniProtKB F phosphatidylinositol 3-kinase binding
GO:0007568 IMP:FlyBase P aging
GO:0000902 IMP:FlyBase P cell morphogenesis
GO:0008340 IMP:FlyBase P determination of adult lifespan
GO:0060250 IMP:FlyBase P germ-line stem-cell niche homeostasis
GO:0007295 IMP:FlyBase P growth of a germarium-derived egg chamber
GO:0008286 IPI:UniProtKB P insulin receptor signaling pathway
GO:0048009 ISS:UniProtKB P insulin-like growth factor receptor signaling pathway
GO:0006629 IMP:FlyBase P lipid metabolic process
GO:0048133 IMP:FlyBase P male germ-line stem cell asymmetric division
GO:0008152 TAS:FlyBase P metabolic process
GO:0035264 IMP:FlyBase P multicellular organism growth
GO:0010259 IMP:UniProtKB P multicellular organismal aging
GO:0008355 IMP:FlyBase P olfactory learning
GO:0030307 NAS:FlyBase P positive regulation of cell growth
GO:0045793 NAS:FlyBase P positive regulation of cell size
GO:0050778 IMP:FlyBase P positive regulation of immune response
GO:0040018 IMP:FlyBase P positive regulation of multicellular organism growth
GO:0046622 NAS:FlyBase P positive regulation of organ growth
GO:0007285 IMP:FlyBase P primary spermatocyte growth
GO:0008361 NAS:FlyBase P regulation of cell size
GO:0040014 TAS:FlyBase P regulation of multicellular organism growth
GO:0046620 IMP:FlyBase P regulation of organ growth
GO:0035159 IMP:FlyBase P regulation of tube length, open tracheal system
GO:0034059 IDA:FlyBase P response to anoxia
GO:0042594 IMP:FlyBase P response to starvation
GO:0007296 IMP:UniProtKB P vitellogenesis

KEGG Pathway Links

KEGG Pathway ID Description
dme04068 FoxO signaling pathway
dme04150 mTOR signaling pathway
ko04150 mTOR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
6226008 Adaptive Immune System
6226970 Constitutive PI3K/AKT Signaling in Cancer
6226001 DAP12 interactions
6226000 DAP12 signaling
6225885 Disease
6225989 Downstream signal transduction
6226491 Downstream signaling events of B Cell Receptor (BCR)
6225992 Downstream signaling of activated FGFR
6226010 Fc epsilon receptor (FCERI) signaling
6226381 GAB1 signalosome
6226021 IGF1R signaling cascade
6226017 IRS-mediated signalling
6226018 IRS-related events
6226020 IRS-related events triggered by IGF1R
6226003 Immune System
6226002 Innate Immune System
6226019 Insulin receptor signalling cascade
6225987 NGF signalling via TRKA from the plasma membrane
6226382 PI-3K cascade
6226023 PI3K Cascade
6226493 PI3K events in ERBB2 signaling
6226492 PI3K events in ERBB4 signaling
6226494 PI3K/AKT Signaling in Cancer
6226486 PI3K/AKT activation
6226490 PIP3 activates AKT signaling
6226495 Role of LAT2/NTAL/LAB on calcium mobilization
6226016 SOS-mediated signalling
6225975 Signal Transduction
6226103 Signal attenuation
6225996 Signaling by EGFR
6225997 Signaling by EGFR in Cancer
6225999 Signaling by ERBB2
6226122 Signaling by ERBB4
6225993 Signaling by FGFR
6225994 Signaling by FGFR in disease
6226015 Signaling by Insulin receptor
6225990 Signaling by PDGF
6226123 Signaling by SCF-KIT
6226022 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
6226007 Signaling by the B Cell Receptor (BCR)
6225988 Signalling by NGF

Domain Information

InterPro Annotations

Accession Description
IPR002404 Insln_rcpt_S1
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
CG5686 gene product from transcript CG5686-RB
Protein Entry
Q9XTN2_DROME
UniProt ID
Q9XTN2
Species
Drosophila

Comments

Comment Type Description
Developmental Stage Expressed during G1, S and G2 phase of the cell cycle. {ECO:0000269|PubMed:10399915}.
Disruption Phenotype Female sterile. Extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. {ECO:0000269|PubMed:11292874, ECO:0000269|PubMed:15890189}.
Function Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation. {ECO:0000250, ECO:0000269|PubMed:10399915, ECO:0000269|PubMed:10801879, ECO:0000269|PubMed:11292874, ECO:0000269|PubMed:15890189}.
Interaction P09208:InR; NbExp=3; IntAct=EBI-176370, EBI-92063;
Miscellaneous 'Chico' means 'small boy' in Spanish. {ECO:0000305}.
Sequence Caution Sequence=AAD55429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Contains 1 IRS-type PTB domain. {ECO:0000255|PROSITE- ProRule:PRU00389}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subunit Bindings to phosphatidylinositol 3-kinase and SHP2.

Identical and Related Proteins

Unique RefSeq proteins for LMP008985 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
320544879 RefSeq NP_001188772 968 chico, isoform B

Identical Sequences to LMP008985 proteins

Reference Database Accession Length Protein Name
GI:320544879 GenBank AAV37022.1 968 GH02661p [Drosophila melanogaster]
GI:320544879 gnl FlyBase 968 chico, isoform B [Drosophila melanogaster]
GI:320544879 gnl FlyBase 968 chico, isoform C [Drosophila melanogaster]
GI:320544879 RefSeq NP_723540.1 968 chico, isoform A [Drosophila melanogaster]
GI:320544879 RefSeq NP_001260316.1 968 chico, isoform C [Drosophila melanogaster]
GI:320544879 SwissProt Q9XTN2.1 968 RecName: Full=Insulin receptor substrate 1; Short=dIRS; AltName: Full=Protein chico [Drosophila melanogaster]

Related Sequences to LMP008985 proteins

Reference Database Accession Length Protein Name
GI:320544879 EMBL CCB63168.1 968 hypothetical protein [Drosophila melanogaster]
GI:320544879 GenBank ACY01726.1 968 chico [Drosophila melanogaster]
GI:320544879 GenBank ACY01727.1 967 chico [Drosophila melanogaster]
GI:320544879 GenBank ACY01729.1 968 chico [Drosophila melanogaster]
GI:320544879 GenBank ACY01741.1 968 chico [Drosophila melanogaster]
GI:320544879 GenBank ACY01742.1 968 chico [Drosophila melanogaster]