Gene/Proteome Database (LMPD)

LMPD ID
LMP009120
Gene ID
41191
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG8412 gene product from transcript CG8412-RA
Gene Symbol
CG8412
Synonyms
Dmel\CG8412
Alternate Names
CG8412; CG8412-PA
Chromosome
3R
Map Location
85E6-85E6
EC Number
2.4.1.260

Proteins

CG8412
Refseq ID NP_649939
Protein GI 21356043
UniProt ID Q9VH78
mRNA ID NM_141682
Length 678
RefSeq Status REVIEWED
MDILIFVTAAAHLVYTPFTKVEESFNLQAMHDILYLRNNFTQYDHHDYPGVVPRTFIGPLVVSIISAPFVLLFETLSINKFWAQYVVRLVLAGAISVAWNSLRQAVTKIYGVEVRLWFTAITITQFHFMFYMTRPLPNIFALPIVLFAIAYWLRDQHKPFIICSGISILVFRSELALFLGILLVVSLLRRKVSIDGLLKVALPAGVCILAATVLVDSFFWRRLLWPEGEVLWYNTVLNKSSNWGTSPFLWYFYSALPRAMGASLVLVPIGVALEPRIRPLVLSALLFVLLYSILPHKELRFIIYVFPVLNIAAACACQRIWMNSAKSTWHSFLALACGAHLLLNVFITLFLLVISGTNYPGGAALSRLHRLEAGTSNVSVHISNLAAQSGVSRFMEINNEWTYSKDETMNYTQADLVAYTHLLVEAKNKQNTELWASLQNEFDTLEFIDCFNSIGIQYNSLLPVRIKTKPCIGILKKRPVAPKEASKTKEKIAKTKTYPVEKETLLAPVKEFPKVIGDPKMKSRLQVDADDDDGIVSTVEEMSLELETDTEPHAGAETIETPLKEINFQELRTLALGQATKKSRAATKMKIRQIIEQHYRAKGKQIENDSAETQKTQGKAGLRQSVKSIIKQEKIKEMIEQIATMDLTRICDLERTSTKDCLKQVIDKIDDSEGLKSK

Gene Information

Entrez Gene ID
41191
Gene Name
CG8412 gene product from transcript CG8412-RA
Gene Symbol
CG8412
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0000009 ISS:UniProtKB F alpha-1,6-mannosyltransferase activity
GO:0052917 IEA:UniProtKB-EC F dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity
GO:0006488 ISS:UniProtKB P dolichol-linked oligosaccharide biosynthetic process
GO:0097502 ISS:GOC P mannosylation
GO:0006486 ISS:UniProtKB P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
dme01100 Metabolic pathways
dme00510 N-Glycan biosynthesis
ko00510 N-Glycan biosynthesis
dme_M00055 N-glycan precursor biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR005599 GPI mannosyltransferase

UniProt Annotations

Entry Information

Gene Name
CG8412 gene product from transcript CG8412-RA
Protein Entry
ALG12_DROME
UniProt ID
Q9VH78
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity Dolichyl beta-D-mannosyl phosphate + D-Man- alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha- (1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D- GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha- (1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)- D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man- beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
Function Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP- Man(7)GlcNAc(2)) required for protein glycosylation. {ECO:0000250}.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 22 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009120 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21356043 RefSeq NP_649939 678 CG8412

Identical Sequences to LMP009120 proteins

Reference Database Accession Length Protein Name
GI:21356043 GenBank AAL48754.1 678 RE17513p [Drosophila melanogaster]
GI:21356043 GenBank ACL86552.1 678 CG8412-PA, partial [synthetic construct]
GI:21356043 gnl FlyBase 678 CG8412 [Drosophila melanogaster]
GI:21356043 SwissProt Q9VH78.1 678 RecName: Full=Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; AltName: Full=Asparagine-linked glycosylation protein 12 homolog; AltName: Full=Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase; AltName: Full=Mannosyltransferase ALG12 homolog [Drosophila melanogaster]

Related Sequences to LMP009120 proteins

Reference Database Accession Length Protein Name
GI:21356043 GenBank EDV49717.1 678 GG17092 [Drosophila erecta]
GI:21356043 GenBank EDW42821.1 678 GM23833 [Drosophila sechellia]
GI:21356043 GenBank EDW96718.1 678 GE25981 [Drosophila yakuba]
GI:21356043 RefSeq XP_001980759.1 678 GG17092 [Drosophila erecta]
GI:21356043 RefSeq XP_002031835.1 678 GM23833 [Drosophila sechellia]
GI:21356043 RefSeq XP_002097006.1 678 GE25981 [Drosophila yakuba]