Gene/Proteome Database (LMPD)

LMPD ID
LMP009130
Gene ID
38785
Species
Drosophila melanogaster (Drosophila)
Gene Name
melted
Gene Symbol
melt
Synonyms
1441/14; anon-WO03014152.10; CG8624; dMelt; Dmel\CG8624; Melt; Q9VS24_DROME
Chromosome
3L
Map Location
65E4-65E5

Proteins

melted, isoform B
Refseq ID NP_001014572
Protein GI 62472042
UniProt ID Q9VS24
mRNA ID NM_001014572
Length 988
RefSeq Status REVIEWED
MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRVLSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKEEPPHAKIAADIISSIFLNYDKKELMKIALPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAPEAVTPHAPLLMPLLPQCDPQERMAVFQLYLLIVQKSPEVLESCVPQLCGSLLDSDTSSITMQILLKLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHLPTQALLQQEATRLCSAYPVLFTDKVLACVRQKNAALSSQQDVGNGLANKTSGGVTIVSLNSSSPSPPLKPVPVGAPAINTTIVQPASVVSATPTPPPSSASAPIASSTPVSAATPTPQHAGYTRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGLHKSMTRLSNSQINQQPGGSSNGNVVVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPVTSGGVTVTTSPSKVRPHSQGPSTLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVSVHHASPALPQSASNGHAKSVMKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQIMRDPVQQFCEKNFNSIKSYMDEVSQHLPPPTRCSIEERRTKKVAKLHFACQIRGPHCLYSKTCFTMRTRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKCENRSFTELVTSQFPQVKDREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGFLNGSNQPMIEGQLKEKKGKWRLFRRWRTRYFTLSGAHLSCKGSSGGESIDVNQIRSVKVSRGARNIPKAFEIFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKTNSLPARSIGSSKPSF
melted, isoform C
Refseq ID NP_523953
Protein GI 281365757
UniProt ID Q9VS24
mRNA ID NM_079229
Length 994
RefSeq Status REVIEWED
MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRVLSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKEEPPHAKIAADIISSIFLNYDKKELMKIALPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAPEAVTPHAPLLMPLLPQCDPQERMAVFQLYLLIVQKSPEVLESCVPQLCGSLLDSDTSSITMQILLKLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHLPTQALLQQEATRLCSAYPVLFTDKVLACVRQKNAALSSQQDVGNGLANKTSGGVTIVSLNSSSPSPPLKPVPVGAPAINTTIVQPASVVSATPTPPPSSASAPIASSTPVSAATPTPQHAGYTRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGLHKSMTRLSNSQINQQPGGSSNGNVVVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPVTSGGVTVTTSPSKVRPHSQGPSTLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVSVHHASPALPQSASNGHAKSVMKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQIMRDPVQQFCEKNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHFACQIRGPHCLYSKTCFTMRTRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKCENRSFTELVTSQFPQVKDREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGFLNGSNQPMIEGQLKEKKGKWRLFRRWRTRYFTLSGAHLSCKGSSGGESIDVNQIRSVKVSRGARNIPKAFEIFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKTNSLPARSIGSSKPSF
melted, isoform D
Refseq ID NP_001261495
Protein GI 442630656
UniProt ID M9PEK0
mRNA ID NM_001274566
Length 992
RefSeq Status REVIEWED
MHELFNKVLAKRDLSRAGDLFSVPDADIVDDITEVLSEISPIISHADYVKNNNDQSVVEICVTRVLSCIRETKTAERYCAALVDLLRTCLLWNLQPSGTTKEEPPHAKIAADIISSIFLNYDKKELMKIALPVAVQFLPKGNRELSRNLASYLSLAAIDHAGLLSPHTESVMESILSGNYGLLRVLSQVYEVAPEAVTPHAPLLMPLLPQCDPQERMAVFQLYLLIVQKSPEVLESCVPQLCGSLLDSDTSSITMQILLKLSQHSPSLLVDHFEQLRLAAKTNPGTIPLCAQIMTTAGIGSKETAQQALDFVLEHLPTQALLQQEATRLCSAYPVLFTDKVLACVRQKNAALSSQQDVGNGLANKTSGGVTIVSLNSSSPSPPLKPVGAPAINTTIVQPASVVSATPTPPPSSASAPIASSTPVSAATPTPQHAGYTRRVKLGDSRSTGRLHPASNTHRSVTRLNVASGSVGGLHKSMTRLSNSQINQQPGGSSNGNVVVQSGATPKTPTGLSNPPVTPVPPLSNNVVITGHNRHGIPVTSGGVTVTTSPSKVRPHSQGPSTLLNSSTVLMKYSTDALNQSVGSISIPQSAAVATLPSTQTQNAVSVHHASPALPQSASNGHAKSVMKLPVNGNSEVIVSGPTTNVAPRRSDNTSRTLLNANSVMDQRMSTFEPYQIMRDPVQQFCEKNFNSIKSYMDEVSQHLPPPTRCSIEVSNEFAERRTKKVAKLHFACQIRGPHCLYSKTCFTMRTRNPKTWIHMMFLDFQVRHFVKEKCVLSTRESGISNLKNIWQILKCENRSFTELVTSQFPQVKDREILVNELRHSGFLDVFEVSKTDKSNPNCNELEYQWGCFLCNHPDKAVGFLNGSNQPMIEGQLKEKKGKWRLFRRWRTRYFTLSGAHLSCKGSSGGESIDVNQIRSVKVSRGARNIPKAFEIFTADQTLILKPKDGKNAEEWVQCLSIVVAHSQARDNPTAKTNSLPARSIGSSKPSF

Gene Information

Entrez Gene ID
38785
Gene Name
melted
Gene Symbol
melt
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IDA:UniProtKB C plasma membrane
GO:0035091 IDA:FlyBase F phosphatidylinositol binding
GO:0010314 IDA:FlyBase F phosphatidylinositol-5-phosphate binding
GO:0045464 IMP:FlyBase P R8 cell fate specification
GO:0001708 IMP:FlyBase P cell fate specification
GO:0007398 IEP:FlyBase P ectoderm development
GO:0008286 IMP:FlyBase P insulin receptor signaling pathway
GO:0006629 IEA:UniProtKB-KW P lipid metabolic process
GO:0008152 IMP:UniProtKB P metabolic process
GO:0007422 IMP:FlyBase P peripheral nervous system development
GO:2001020 IGI:FlyBase P regulation of response to DNA damage stimulus
GO:0030730 IMP:FlyBase P sequestering of triglyceride

Domain Information

InterPro Annotations

Accession Description
IPR011989 Armadillo-like helical
IPR016024 Armadillo-type fold
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
melted
Protein Entry
MELT_DROME
UniProt ID
Q9VS24
Species
Drosophila

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=C; IsoId=Q9VS24-3; Sequence=Displayed; Name=B; IsoId=Q9VS24-2; Sequence=VSP_027438;
Domain The PH domain is required for membrane targeting.
Function Participates in fat metabolism regulation by recruiting FOXO and the TSC1-TSC2 complex to the cell membrane, which positively regulates TOR activity and negatively regulates the expression of FOXO target genes. Involved in R8 photoreceptor subtype specification. During early embryonic development, may be required for ectodermal patterning. {ECO:0000269|PubMed:11102367, ECO:0000269|PubMed:16054033, ECO:0000269|PubMed:16143107}.
Similarity Belongs to the MELT/VEPH family. {ECO:0000305}.
Similarity Contains 1 PH domain.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:16054033}; Peripheral membrane protein {ECO:0000269|PubMed:16054033}; Cytoplasmic side {ECO:0000269|PubMed:16054033}.
Subunit Interacts with TSC1 and FOXO. {ECO:0000269|PubMed:16054033}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009130 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62472042 RefSeq NP_001014572 988 melted, isoform B
281365757 RefSeq NP_523953 994 melted, isoform C
442630656 RefSeq NP_001261495 992 melted, isoform D

Identical Sequences to LMP009130 proteins

Reference Database Accession Length Protein Name
GI:62472042 EMBL CAD88638.1 988 unnamed protein product [Drosophila melanogaster]
GI:281365757 GenBank ABJ17062.1 994 IP16092p [Drosophila melanogaster]
GI:62472042 gnl FlyBase 988 melted, isoform B [Drosophila melanogaster]
GI:281365757 gnl FlyBase 994 melted, isoform C [Drosophila melanogaster]
GI:442630656 gnl FlyBase 992 melted, isoform D [Drosophila melanogaster]
GI:281365757 SwissProt Q9VS24.2 994 RecName: Full=Protein melted [Drosophila melanogaster]

Related Sequences to LMP009130 proteins

Reference Database Accession Length Protein Name
GI:281365757 EMBL CAD88638.1 988 unnamed protein product [Drosophila melanogaster]
GI:62472042 GenBank ABJ17062.1 994 IP16092p [Drosophila melanogaster]
GI:442630656 GenBank ABJ17062.1 994 IP16092p [Drosophila melanogaster]
GI:281365757 GenBank EDW93711.1 988 GE21597 [Drosophila yakuba]
GI:442630656 gnl FlyBase 988 melted, isoform B [Drosophila melanogaster]
GI:281365757 gnl FlyBase 988 melted, isoform B [Drosophila melanogaster]
GI:62472042 gnl FlyBase 994 melted, isoform C [Drosophila melanogaster]
GI:442630656 gnl FlyBase 994 melted, isoform C [Drosophila melanogaster]
GI:281365757 gnl FlyBase 992 melted, isoform D [Drosophila melanogaster]
GI:62472042 gnl FlyBase 992 melted, isoform D [Drosophila melanogaster]
GI:442630656 RefSeq NP_001014572.1 988 melted, isoform B [Drosophila melanogaster]
GI:281365757 RefSeq NP_001014572.1 988 melted, isoform B [Drosophila melanogaster]
GI:62472042 RefSeq NP_523953.2 994 melted, isoform C [Drosophila melanogaster]
GI:442630656 RefSeq NP_523953.2 994 melted, isoform C [Drosophila melanogaster]
GI:281365757 RefSeq NP_001261495.1 992 melted, isoform D [Drosophila melanogaster]
GI:62472042 RefSeq NP_001261495.1 992 melted, isoform D [Drosophila melanogaster]
GI:442630656 SwissProt Q9VS24.2 994 RecName: Full=Protein melted [Drosophila melanogaster]
GI:62472042 SwissProt Q9VS24.2 994 RecName: Full=Protein melted [Drosophila melanogaster]