Gene/Proteome Database (LMPD)
LMPD ID
LMP009880
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ATP-citrate lyase A-3
Gene Symbol
Synonyms
ATP-citrate lyase A-3; F14J9.9; F14J9_9
Alternate Names
ATP-citrate lyase A-3
Chromosome
1
EC Number
2.3.3.8
Summary
Encodes subunit A of the heteromeric enzyme ATP citrate lyase (ACL). In animals, ACL is encoded by a single gene; ACL in Arabidopsis is composed of two polypeptides, ACLA (encoded by 3 genes) and ACLB (encoded by 2 genes). The holoenzyme has an A(4)B(4)stoichiometry. Expression of both ACLA and ACLB but not of either of the subunits alone results in ACL activity.
Orthologs
Proteins
| ATP-citrate lyase A-3 | |
|---|---|
| Refseq ID | NP_172414 |
| Protein GI | 15217510 |
| UniProt ID | O80526 |
| mRNA ID | NM_100814 |
| Length | 424 |
| RefSeq Status | REVIEWED |
| MARKKIREYDSKRLLKEHLKRLANIDLQIRSAQVTESTDFTELTNQESWLSSTKLVVKPDMLFGKRGKSGLVALKLDLAEVADFVKARLGTEVEMEGCKAPITTFIVEPFVPHDQEYYLSIVSDRLGCTISFSECGGIEIEENWDKVKTIFLPAEKSMTLEVCAPLIATLPLEVRAKIGNFIMGAFAVFQDLDFSFMEMNPFTLVDGEPFPLDMRGELDDTAAFKNFNKWGDIEFPLPFGRVLSSTENFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASELGNYAEYSGAPNEEEVLQYARVVIDCATTDPDGRKRALLIGGGIANFTDVAATFNGIIRALREKETRLKASRMHIYVRRGGPNYQTGLARMRALGEELGVPLEVYGPEATMTGICKRAIDCIMLPDA | |
Gene Information
Entrez Gene ID
Gene Name
ATP-citrate lyase A-3
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009346 | ISS:TAIR | C | citrate lyase complex |
| GO:0005829 | IDA:TAIR | C | cytosol |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0003878 | ISS:TAIR | F | ATP citrate synthase activity |
| GO:0006085 | TAS:TAIR | P | acetyl-CoA biosynthetic process |
| GO:0006629 | IEA:UniProtKB-KW | P | lipid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath01110 | Biosynthesis of secondary metabolites |
| ath00020 | Citrate cycle (TCA cycle) |
| ath01100 | Metabolic pathways |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 6253967 | ChREBP activates metabolic gene expression |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. |
| Function | ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. In contrast to all known animal ACL enzymes having a homomeric structure, plant ACLs are composed of alpha and beta chains (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the succinate/malate CoA ligase beta subunit family. {ECO:0000305}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. |
| Subunit | Heterooctamer of 4 alpha and 4 beta chains. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP009880 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15217510 | RefSeq | NP_172414 | 424 | ATP-citrate lyase A-3 |
Identical Sequences to LMP009880 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15217510 | GenBank | AAM83243.1 | 424 | At1g09430/F19J9_9 [Arabidopsis thaliana] |
| GI:15217510 | GenBank | AAO23582.1 | 424 | At1g09430/F19J9_9 [Arabidopsis thaliana] |
| GI:15217510 | GenBank | ABN27997.1 | 424 | Sequence 394 from patent US 7157621 |
| GI:15217510 | GenBank | AEE28442.1 | 424 | ATP-citrate lyase A-3 [Arabidopsis thaliana] |
| GI:15217510 | GenBank | AGD03051.1 | 424 | Sequence 507 from patent US 8343764 |
| GI:15217510 | SwissProt | O80526.1 | 424 | RecName: Full=ATP-citrate synthase alpha chain protein 3; Short=ATP-citrate synthase A-3; AltName: Full=ATP-citrate lyase A-3; AltName: Full=Citrate cleavage enzyme A-3 [Arabidopsis thaliana] |
Related Sequences to LMP009880 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15217510 | GenBank | EFH66008.1 | 424 | ATP-citrate lyase A-3 [Arabidopsis lyrata subsp. lyrata] |
| GI:15217510 | GenBank | EOA40505.1 | 424 | hypothetical protein CARUB_v10009231mg [Capsella rubella] |
| GI:15217510 | RefSeq | XP_002889749.1 | 424 | ATP-citrate lyase A-3 [Arabidopsis lyrata subsp. lyrata] |
| GI:15217510 | RefSeq | XP_006307607.1 | 424 | hypothetical protein CARUB_v10009231mg [Capsella rubella] |
| GI:15217510 | RefSeq | XP_010489987.1 | 424 | PREDICTED: ATP-citrate synthase alpha chain protein 3 [Camelina sativa] |
| GI:15217510 | RefSeq | XP_010489993.1 | 424 | PREDICTED: ATP-citrate synthase alpha chain protein 3 [Camelina sativa] |