Gene/Proteome Database (LMPD)
LMPD ID
LMP009881
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ATP-citrate lyase B-1
Gene Symbol
Synonyms
ATP-citrate lyase B-1; T8E24.7; T8E24_7
Alternate Names
ATP-citrate lyase B-1
Chromosome
3
EC Number
2.3.3.8
Summary
One of the two genes encoding subunit B of the trimeric enzyme ATP Citrate lyase
Orthologs
Proteins
| ATP-citrate lyase B-1 | |
|---|---|
| Refseq ID | NP_187317 |
| Protein GI | 15230764 |
| UniProt ID | Q9C522 |
| mRNA ID | NM_111541 |
| Length | 608 |
| RefSeq Status | REVIEWED |
| MATGQLFSRNTQALFYNYKQLPIQRMLDFDFLCGRETPSVAGIINPGSEGFQKLFFGQEEIAIPVHAAIEAACAAHPTADVFINFASFRSAAASSMAALKQPTIKVVAIIAEGVPESDTKQLIAYARANNKVIIGPATVGGVQAGAFKIGDTAGTIDNIIQCKLYRPGSVGFVSKSGGMSNEMYNTIARVTDGIYEGIAIGGDVFPGSTLSDHILRFNNIPQIKMVVVLGELGGRDEYSLVEAMKQGKVTKPVVAWVSGTCARLFKSEVQFGHAGAKSGGEMESAQAKNQALQDAGATVPTSFEALEVAIKETFDKLVEEGKVSPIKEVTPPQIPEDLSSAIKSGKVRAPTHIISTISDDRGEEPCYAGVPMSSIIEQGYGVGDVISLLWFKRSLPRYCTKFIEICIMLCADHGPCVSGAHNTIVTARAGKDLVSSLVSGLLTIGPRFGGAIDDAARYFKDACDRNLTPYEFVEGMKKKGIRVPGIGHRIKSRDNRDKRVELLQKFARSNFPAVKYMEYAVQVETYTLSKANNLVLNVDGAIGSLFLDLLAGSGMFTKQEIDEIVQIGYLNGLFVLARSIGLIGHTFDQKRLKQPLYRHPWEDVLYTK | |
Gene Information
Entrez Gene ID
Gene Name
ATP-citrate lyase B-1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009346 | ISS:TAIR | C | citrate lyase complex |
| GO:0005829 | IDA:TAIR | C | cytosol |
| GO:0016020 | IDA:TAIR | C | membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0003878 | ISS:TAIR | F | ATP citrate synthase activity |
| GO:0048037 | IEA:InterPro | F | cofactor binding |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0004775 | IEA:InterPro | F | succinate-CoA ligase (ADP-forming) activity |
| GO:0006085 | TAS:TAIR | P | acetyl-CoA biosynthetic process |
| GO:0044262 | IEA:InterPro | P | cellular carbohydrate metabolic process |
| GO:0006629 | IEA:UniProtKB-KW | P | lipid metabolic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005811 | ATP-citrate lyase/succinyl-CoA ligase |
| IPR017440 | ATP-citrate lyase/succinyl-CoA ligase, active site |
| IPR002020 | Citrate synthase-like |
| IPR016141 | Citrate synthase-like, core |
| IPR016142 | Citrate synthase-like, large alpha subdomain |
| IPR016143 | Citrate synthase-like, small alpha subdomain |
| IPR003781 | CoA-binding |
| IPR016040 | NAD(P)-binding domain |
| IPR005810 | Succinyl-CoA ligase, alpha subunit |
| IPR017866 | Succinyl-CoA synthetase, beta subunit, conserved site |
| IPR016102 | Succinyl-CoA synthetase-like |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. |
| Function | ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. In contrast to all known animal ACL enzymes having a homomeric structure, plant ACLs are composed of alpha and beta chains (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000305}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. |
| Subunit | Heterooctamer of 4 alpha and 4 beta chains. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP009881 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15230764 | RefSeq | NP_187317 | 608 | ATP-citrate lyase B-1 |
Identical Sequences to LMP009881 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15230764 | GenBank | AAG50997.1 | 608 | ATP citrate lyase, putative; 38389-41775 [Arabidopsis thaliana] |
| GI:15230764 | GenBank | AAG51326.1 | 608 | ATP citrate lyase, putative; 3734-7120 [Arabidopsis thaliana] |
| GI:15230764 | GenBank | AAO22565.1 | 608 | putative ATP citrate lyase [Arabidopsis thaliana] |
| GI:15230764 | GenBank | AEE74426.1 | 608 | ATP-citrate lyase B-1 [Arabidopsis thaliana] |
| GI:15230764 | SwissProt | Q9C522.1 | 608 | RecName: Full=ATP-citrate synthase beta chain protein 1; Short=ATP-citrate synthase B-1; AltName: Full=ATP-citrate lyase B-1; AltName: Full=Citrate cleavage enzyme B-1 [Arabidopsis thaliana] |
Related Sequences to LMP009881 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15230764 | GenBank | EFH60859.1 | 608 | ATP-citrate lyase B-1 [Arabidopsis lyrata subsp. lyrata] |
| GI:15230764 | RefSeq | XP_002884600.1 | 608 | ATP-citrate lyase B-1 [Arabidopsis lyrata subsp. lyrata] |
| GI:15230764 | RefSeq | XP_010442772.1 | 608 | PREDICTED: ATP-citrate synthase beta chain protein 1 [Camelina sativa] |
| GI:15230764 | RefSeq | XP_010442848.1 | 608 | PREDICTED: ATP-citrate synthase beta chain protein 1 [Camelina sativa] |
| GI:15230764 | RefSeq | XP_010486180.1 | 608 | PREDICTED: ATP-citrate synthase beta chain protein 1 isoform X1 [Camelina sativa] |
| GI:15230764 | RefSeq | XP_010486181.1 | 608 | PREDICTED: ATP-citrate synthase beta chain protein 1 isoform X2 [Camelina sativa] |