Gene/Proteome Database (LMPD)

LMPD ID
LMP010071
Gene ID
817157
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
cytochrome P450, family 711, subfamily A, polypeptide 1
Gene Symbol
CYP711A1
Synonyms
cytochrome P450; family 711; MAX1; MORE AXILLARY BRANCHES 1; polypeptide 1; subfamily A; T1D16.19; T1D16_19
Alternate Names
cytochrome P450, family 711, subfamily A, polypeptide 1
Chromosome
2
EC Number
1.14.-.-
Summary
Encodes a protein with similarity to thromboxane-A synthase, member of the CYP711A cytochrome P450 family. MAX1 is a specific repressor of vegetative axillary buds generated by the axillary meristem. Expressed in vascular traces in the rosette stem and axillary buds throughout plant development. Mutants have increased axillary branches. Along with MAX3,4 thought to mediate control of shoot branching via synthesis of a signal molecule which is transported over long distance mediated by MAX2. cDNA supports the existence of the longer transcript predicted for this locus, no cDNA isolated for shorter transcript. MAX1 downregulates 11 genes involved in flavonoid pathway (CHS, CHI, F3H, F3'H, FLS, DFR, ANS, UFGT, RT, AAC and GST).
Orthologs
View orthologs and multiple alignments for CYP711A1

Proteins

cytochrome P450, family 711, subfamily A, polypeptide 1
Refseq ID NP_850074
Protein GI 30683028
UniProt ID B9DFU2
mRNA ID NM_179743
Length 439
RefSeq Status REVIEWED
MGRQPLIIIAEAELCREVGIKKFKDLPNRSIPSPISASPLHKKGLFFTRDKRWSKMRNTILSLYQPSHLTSLIPTMHSFITSATHNLDSKPRDIVFSNLFLKLTTDIIGQAAFGVDFGLSGKKPIKDVEVTDFINQHVYSTTQLKMDLSGSLSIILGLLIPILQEPFRQVLKRIPGTMDWRVEKTNARLSGQLNEIVSKRAKEAETDSKDFLSLILKARESDPFAKNIFTSDYISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKRLLQEIDGFGNRDLIPTAHDLQHKFPYLDQVIKEAMRFYMVSPLVARETAKEVEIGGYLLPKGTWVWLALGVLAKDPKNFPEPEKFKPERFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLEMEIPLQLDYGIILSFKNGVKLRTIKRF
cytochrome P450, family 711, subfamily A, polypeptide 1
Refseq ID NP_565617
Protein GI 30683024
UniProt ID B9DFU2
mRNA ID NM_128175
Length 522
RefSeq Status REVIEWED
MKTQHQWWEVLDPFLTQHEALIAFLTFAAVVIVIYLYRPSWSVCNVPGPTAMPLVGHLPLMAKYGPDVFSVLAKQYGPIFRFQMGRQPLIIIAEAELCREVGIKKFKDLPNRSIPSPISASPLHKKGLFFTRDKRWSKMRNTILSLYQPSHLTSLIPTMHSFITSATHNLDSKPRDIVFSNLFLKLTTDIIGQAAFGVDFGLSGKKPIKDVEVTDFINQHVYSTTQLKMDLSGSLSIILGLLIPILQEPFRQVLKRIPGTMDWRVEKTNARLSGQLNEIVSKRAKEAETDSKDFLSLILKARESDPFAKNIFTSDYISAVTYEHLLAGSATTAFTLSSVLYLVSGHLDVEKRLLQEIDGFGNRDLIPTAHDLQHKFPYLDQVIKEAMRFYMVSPLVARETAKEVEIGGYLLPKGTWVWLALGVLAKDPKNFPEPEKFKPERFDPNGEEEKHRHPYAFIPFGIGPRACVGQRFALQEIKLTLLHLYRNYIFRHSLEMEIPLQLDYGIILSFKNGVKLRTIKRF

Gene Information

Entrez Gene ID
817157
Gene Name
cytochrome P450, family 711, subfamily A, polypeptide 1
Gene Symbol
CYP711A1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:UniProtKB-KW F monooxygenase activity
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0009926 IMP:TAIR P auxin polar transport
GO:0016117 TAS:TAIR P carotenoid biosynthetic process
GO:0009963 IEP:TAIR P positive regulation of flavonoid biosynthetic process
GO:0009934 IMP:TAIR P regulation of meristem structural organization
GO:0010223 IMP:TAIR P secondary shoot formation

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 711, subfamily A, polypeptide 1
Protein Entry
MAX1_ARATH
UniProt ID
B9DFU2
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B9DFU2-1; Sequence=Displayed; Name=2; IsoId=B9DFU2-2; Sequence=VSP_046323;
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Disruption Phenotype Increased shoot branching. {ECO:0000269|PubMed:15737939, ECO:0000269|PubMed:16387852, ECO:0000269|PubMed:20667910, ECO:0000269|PubMed:21119045, ECO:0000269|PubMed:23204501}.
Function Acts downstream of CCD7/MAX3 and CCD8/MAX4 in strigolactone signaling pathway and may be implicated in synthesis of carotenoid-derived branch regulators. Acts as a positive regulator of the flavonoid pathway in the late vegetative stage plant. Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate- limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds. {ECO:0000269|PubMed:15737939, ECO:0000269|PubMed:16387852}.
Miscellaneous The branching phenotypes of the max1, ccd7/max3 and ccd8/max4 mutants can be rescued by exogenous treatment with the synthetic strigolactone analogs GR24 and 4BD. {ECO:0000305|PubMed:23204501}.
Sequence Caution Sequence=AAL91286.1; Type=Frameshift; Positions=102; Evidence={ECO:0000305};
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Single-pass membrane protein.
Tissue Specificity Expressed in the vascular cylinder (including the pericycle) in roots, the cambial region of vascular bundles in inflorescence stems and the vascular junctions of axillary regions in leaves and flowers. {ECO:0000269|PubMed:15737939}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010071 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30683024 RefSeq NP_565617 522 cytochrome P450, family 711, subfamily A, polypeptide 1
30683028 RefSeq NP_850074 439 cytochrome P450, family 711, subfamily A, polypeptide 1

Identical Sequences to LMP010071 proteins

Reference Database Accession Length Protein Name
GI:30683024 DBBJ BAH19609.1 522 AT2G26170 [Arabidopsis thaliana]
GI:30683028 GenBank AAM15001.1 439 putative thromboxane-A synthase [Arabidopsis thaliana]
GI:30683028 GenBank ACW94585.1 439 Sequence 13848 from patent US 7569389
GI:30683024 GenBank AEC07803.1 522 cytochrome P450, family 711, subfamily A, polypeptide 1 [Arabidopsis thaliana]
GI:30683028 GenBank AEC07804.1 439 cytochrome P450, family 711, subfamily A, polypeptide 1 [Arabidopsis thaliana]
GI:30683024 GenBank AFX48839.1 522 Sequence 50672 from patent US 8299318
GI:30683024 GenBank AGF15026.1 522 Sequence 14445 from patent US 8362325
GI:30683028 gnl TIGR 439 putative thromboxane-A synthase [Arabidopsis thaliana]
GI:30683024 SwissProt B9DFU2.1 522 RecName: Full=Cytochrome P450 711A1; AltName: Full=Protein MORE AXILLARY BRANCHES 1 [Arabidopsis thaliana]

Related Sequences to LMP010071 proteins

Reference Database Accession Length Protein Name
GI:30683028 DBBJ BAH19609.1 522 AT2G26170 [Arabidopsis thaliana]
GI:30683024 GenBank EFH55196.1 522 CYP711A1 [Arabidopsis lyrata subsp. lyrata]
GI:30683028 GenBank AEC07803.1 522 cytochrome P450, family 711, subfamily A, polypeptide 1 [Arabidopsis thaliana]
GI:30683028 GenBank AFX48839.1 522 Sequence 50672 from patent US 8299318
GI:30683028 GenBank AGF15026.1 522 Sequence 14445 from patent US 8362325
GI:30683028 RefSeq NP_565617.2 522 cytochrome P450, family 711, subfamily A, polypeptide 1 [Arabidopsis thaliana]
GI:30683024 RefSeq XP_002878937.1 522 CYP711A1 [Arabidopsis lyrata subsp. lyrata]
GI:30683024 RefSeq XP_006294008.1 525 hypothetical protein CARUB_v10022996mg [Capsella rubella]
GI:30683024 RefSeq XP_010417399.1 522 PREDICTED: cytochrome P450 711A1 [Camelina sativa]
GI:30683024 RefSeq XP_010429637.1 517 PREDICTED: cytochrome P450 711A1-like [Camelina sativa]
GI:30683024 RefSeq XP_010472644.1 536 PREDICTED: cytochrome P450 711A1-like [Camelina sativa]
GI:30683028 SwissProt B9DFU2.1 522 RecName: Full=Cytochrome P450 711A1; AltName: Full=Protein MORE AXILLARY BRANCHES 1 [Arabidopsis thaliana]