Gene/Proteome Database (LMPD)

LMPD ID
LMP010536
Gene ID
821808
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
lipoxygenase 5
Gene Symbol
LOX5
Alternate Names
lipoxygenase 5
Chromosome
3
EC Number
1.13.11.58

Proteins

lipoxygenase 5
Refseq ID NP_188879
Protein GI 30686619
UniProt ID Q9LUW0
mRNA ID NM_113137
Length 886
RefSeq Status REVIEWED
MIHTDIAEILCVKPKTTKKTKTMEEDVKKTTTMKIEGEVVVMKKNLLDFKDVMASLLDRVNELLGRRVSLHLISSHQPDPANEKRGRLGKAAHLEKWVTKIKTSVTAEETAFGVTFDWDESMGPPAAFVIKNHHHSQFYLKSLTLRGFPDGEGGATAIHFICNSWIYPNHRYRSDRVFFSNKAYLPSETPELIKELREEELKNLRGNEKGGEFKEWDRVYDYAYYNDLGAPDKGPDSVRPVLGGSPELPYPRRGKTGRKSTKSDPKSESRLALLNLNIYVPRDERFSHVKFSDFLAYALKSVTQVLVPEIASVCDKTINEFDSFEDVFHLYDGSIKLANGHTISKLRDVIPWEMFRELVRNDGERFLKYPLPDILKESRSAWRTDEEFAREMLAGLNPVVISRLQEFPPKSCLDSAKYGNQHSSIRTEHIESNMNGLNVQEALEQNKLYILDHHDALMPYLTRINSTNTKTYATRTLLLLQADGTLKPLAIELSLPHAQGESYGSVSKVFTPAEKGVEGSVWQLAKAYAAVNDSGYHQLISHWLQTHAVIEPFIIASNRQLSVVHPIHKLLHPHFRDTMNINALARHVLINSDGVLERTVFPSRYAMEMSSSIYKNWVFTEQALPKDLLKRGVAVEDPNSDNGVKLLIEDYPFAVDGLEIWSAIKTWVTEYCTFYYNNDKTVQTDTEIQSWWTELRTKGHGDKRHESWWPSMQTRDDLIETCTIIIWIASALHAAVNFGQYPYAGFLPNRPTVSRRFMPEPGTDEYAELEEDADVAFLKTITPQLQTLLGISIIEILSMHSTDEIYLGQRDSPNWTADDEPLEAFKRFGKELELIENNIIRRNNDKRFKNRTGPVNIPYTLLYPNTTDYTREGGITGKGIPNSVSI

Gene Information

Entrez Gene ID
821808
Gene Name
lipoxygenase 5
Gene Symbol
LOX5
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0005506 IEA:InterPro F iron ion binding
GO:0016165 IEA:InterPro F linoleate 13S-lipoxygenase activity
GO:1990136 IDA:UniProtKB F linoleate 9S-lipoxygenase activity
GO:0010311 IMP:UniProtKB P lateral root formation
GO:0034440 IDA:TAIR P lipid oxidation
GO:1900366 IMP:TAIR P negative regulation of defense response to insect
GO:0031408 IEA:UniProtKB-UniPathway P oxylipin biosynthetic process
GO:0048364 IMP:TAIR P root development

KEGG Pathway Links

KEGG Pathway ID Description
ath00591 Linoleic acid metabolism
ko00591 Linoleic acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR013819 Lipoxygenase, C-terminal
IPR020834 Lipoxygenase, conserved site
IPR027433 Lipoxygenase, domain 3
IPR020833 Lipoxygenase, iron binding site
IPR001246 Lipoxygenase, plant
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
lipoxygenase 5
Protein Entry
LOX5_ARATH
UniProt ID
Q9LUW0
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Linoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy- 10,12-octadecadienoate.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|PROSITE-ProRule:PRU00726}; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
Developmental Stage First observed in lateral root primordia (LRP), from the first pericycle divisions. Disappears before root emergence. {ECO:0000269|PubMed:17369372}.
Disruption Phenotype Increment in the number of lateral roots, and moderate increase in the length of the primary root. {ECO:0000269|PubMed:17369372}.
Function 9S-lipoxygenase that can use linoleic acid or linolenic acid as substrates. Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. Function as regulators of root development by controlling the emergence of lateral roots. {ECO:0000269|PubMed:17369372, ECO:0000269|PubMed:18949503}.
Pathway Lipid metabolism; oxylipin biosynthesis. {ECO:0000255|PROSITE-ProRule:PRU00726}.
Sequence Caution Sequence=BAB01777.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the lipoxygenase family. {ECO:0000305}.
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Similarity Contains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
Subcellular Location Plastid, chloroplast {ECO:0000269|PubMed:15028209}.
Tissue Specificity Expressed in roots. {ECO:0000269|PubMed:17369372}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010536 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30686619 RefSeq NP_188879 886 lipoxygenase 5

Identical Sequences to LMP010536 proteins

Reference Database Accession Length Protein Name
GI:30686619 GenBank AEE76630.1 886 lipoxygenase 5 [Arabidopsis thaliana]
GI:30686619 SwissProt Q9LUW0.2 886 RecName: Full=Linoleate 9S-lipoxygenase 5, chloroplastic; AltName: Full=Lipoxygenase 5; Short=AtLOX5 [Arabidopsis thaliana]

Related Sequences to LMP010536 proteins

Reference Database Accession Length Protein Name
GI:30686619 DBBJ BAB01777.1 882 lipoxygenase [Arabidopsis thaliana]
GI:30686619 EMBL CAC19365.1 854 lipoxygenase, partial [Arabidopsis thaliana]
GI:30686619 GenBank ESQ47622.1 888 hypothetical protein EUTSA_v10020023mg [Eutrema salsugineum]
GI:30686619 RefSeq XP_006406169.1 888 hypothetical protein EUTSA_v10020023mg [Eutrema salsugineum]
GI:30686619 RefSeq XP_010511287.1 886 PREDICTED: linoleate 9S-lipoxygenase 5, chloroplastic isoform X1 [Camelina sativa]
GI:30686619 RefSeq XP_010466519.1 889 PREDICTED: linoleate 9S-lipoxygenase 5, chloroplastic-like [Camelina sativa]