Gene/Proteome Database (LMPD)

LMPD ID
LMP010543
Gene ID
814646
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
lipid phosphate phosphatase 1
Gene Symbol
PAP1
Synonyms
ATLPP1; ATPAP1; F10A8.6; F10A8_6; LIPID PHOSPHATE PHOSPHATASE 1; LPP1; PAP1; phosphatidic acid phosphatase 1
Alternate Names
lipid phosphate phosphatase 1
Chromosome
2
EC Number
3.1.3.-
Summary
Encodes phosphatidate phosphatase. Up-regulated by genotoxic stress (gamma ray or UV-B) and elicitor treatments with mastoparan and harpin. Expressed in roots and leaves.
Orthologs
View orthologs and multiple alignments for PAP1

Proteins

lipid phosphate phosphatase 1
Refseq ID NP_973389
Protein GI 42570631
UniProt ID Q9ZU49
mRNA ID NM_201660
Length 302
RefSeq Status REVIEWED
MQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMESGTSTAPR
lipid phosphate phosphatase 1
Refseq ID NP_565255
Protein GI 18379166
UniProt ID Q9ZU49
mRNA ID NM_126179
Length 327
RefSeq Status REVIEWED
MTIGSFFSSLLFWRNSQDQEAQRGRMQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMESGTSTAPR

Gene Information

Entrez Gene ID
814646
Gene Name
lipid phosphate phosphatase 1
Gene Symbol
PAP1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005887 TAS:TAIR C integral component of plasma membrane
GO:0005886 IDA:TAIR C plasma membrane
GO:0008195 IDA:TAIR F phosphatidate phosphatase activity
GO:0016311 IDA:GOC P dephosphorylation
GO:0009626 IEA:UniProtKB-KW P plant-type hypersensitive response
GO:0010224 IEP:TAIR P response to UV-B

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7039 phosphatidate metabolism, as a signaling molecule

REACTOME Pathway Links

REACTOME Pathway ID Description
6253980 Fcgamma receptor (FCGR) dependent phagocytosis
6253979 Role of phospholipids in phagocytosis

Domain Information

InterPro Annotations

Accession Description
IPR028681 Lipid phosphate phosphatase, plant
IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase

UniProt Annotations

Entry Information

Gene Name
lipid phosphate phosphatase 1
Protein Entry
LPP1_ARATH
UniProt ID
Q9ZU49
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9ZU49-1; Sequence=Displayed; Name=2; IsoId=Q9ZU49-2; Sequence=VSP_053601; Note=No experimental confirmation available.;
Enzyme Regulation PA phosphatase activity inhibited by N- ethylmaleimide with an IC(50) value of 10 mM. {ECO:0000269|PubMed:11278556}.
Function Plays a general role in cellular responses to stress, may be by attenuating the signal produced by phospholipases. Exhibits both diacylglycerol pyrophosphate (DGPP) phosphatase and phosphatidate (PA) phosphatase activities. Substrate preference is diacylglycerol pyrophosphate > phosphatidate. {ECO:0000269|PubMed:11278556}.
Induction Rapid increase in response to severe radiation stress (gamma rays or UV-B). Returns to basal level 45 min after the radiation injury. Also induced by mastoparan and by the hypersensitive response elicitor harpin. In this later case, induction is also observed in the leaves adjacent to those that were infiltrated with harpin. {ECO:0000269|PubMed:11278556}.
Sequence Caution Sequence=BX819931; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
Similarity Belongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Strongly expressed in leaves, moderately in roots, weakly in floral hamps and flower buds, and not detected in adult flowers and seedpods. {ECO:0000269|PubMed:11278556}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010543 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18379166 RefSeq NP_565255 327 lipid phosphate phosphatase 1
42570631 RefSeq NP_973389 302 lipid phosphate phosphatase 1

Identical Sequences to LMP010543 proteins

Reference Database Accession Length Protein Name
GI:42570631 DBBJ BAC41334.1 302 prenyl diphosphate phosphatase [Arabidopsis thaliana]
GI:42570631 EMBL CAK96028.1 302 unnamed protein product [Arabidopsis thaliana]
GI:42570631 GenBank ACC28549.1 302 Sequence 19 from patent US 7345216
GI:18379166 GenBank ACW98003.1 327 Sequence 18484 from patent US 7569389
GI:42570631 GenBank ACW98004.1 302 Sequence 18485 from patent US 7569389
GI:18379166 GenBank ACW99680.1 327 Sequence 20772 from patent US 7569389
GI:42570631 GenBank ACW99681.1 302 Sequence 20773 from patent US 7569389
GI:18379166 GenBank ADT60107.1 327 Sequence 1104 from patent US 7847156
GI:42570631 GenBank AEC05411.1 302 lipid phosphate phosphatase 1 [Arabidopsis thaliana]
GI:18379166 GenBank AEC05412.1 327 lipid phosphate phosphatase 1 [Arabidopsis thaliana]
GI:18379166 gnl TIGR 327 putative phosphatidic acid phosphatase [Arabidopsis thaliana]
GI:18379166 SwissProt Q9ZU49.2 327 RecName: Full=Lipid phosphate phosphatase 1; Short=AtLPP1; AltName: Full=Phosphatidic acid phosphatase 1; Short=AtPAP1; AltName: Full=Prenyl diphosphate phosphatase [Arabidopsis thaliana]

Related Sequences to LMP010543 proteins

Reference Database Accession Length Protein Name
GI:42570631 DBBJ BAB47575.1 327 phosphatidic acid phosphatase [Arabidopsis thaliana]
GI:18379166 GenBank AAL06503.1 327 At2g01180/F10A8.6 [Arabidopsis thaliana]
GI:18379166 GenBank AAM63082.1 327 putative phosphatidic acid phosphatase [Arabidopsis thaliana]
GI:18379166 GenBank AAN28825.1 327 At2g01180/F10A8.6 [Arabidopsis thaliana]
GI:18379166 GenBank AAO95196.1 348 Sequence 13 from patent US 6495739
GI:42570631 GenBank ACW99680.1 327 Sequence 20772 from patent US 7569389
GI:18379166 GenBank EFH52994.1 327 ATPAP1 [Arabidopsis lyrata subsp. lyrata]
GI:42570631 GenBank AEC05412.1 327 lipid phosphate phosphatase 1 [Arabidopsis thaliana]
GI:42570631 gnl TIGR 327 putative phosphatidic acid phosphatase [Arabidopsis thaliana]
GI:42570631 RefSeq NP_565255.1 327 lipid phosphate phosphatase 1 [Arabidopsis thaliana]
GI:18379166 RefSeq XP_002876735.1 327 ATPAP1 [Arabidopsis lyrata subsp. lyrata]
GI:42570631 SwissProt Q9ZU49.2 327 RecName: Full=Lipid phosphate phosphatase 1; Short=AtLPP1; AltName: Full=Phosphatidic acid phosphatase 1; Short=AtPAP1; AltName: Full=Prenyl diphosphate phosphatase [Arabidopsis thaliana]