Gene/Proteome Database (LMPD)

LMPD ID
LMP010617
Gene ID
829549
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
methylcrotonoyl-CoA carboxylase beta chain
Gene Symbol
MCCB
Synonyms
3-methylcrotonyl-CoA carboxylase; 3-METHYLCROTONYL-COA CARBOXYLASE; F28A23.210; F28A23_210; MCCB
Alternate Names
methylcrotonoyl-CoA carboxylase beta chain
Chromosome
4
EC Number
6.4.1.4
Summary
MCC-B is involved in leucine degradation in mitochondria. The active protein is a dimer of MCC-A and MCC-B. MCC-A is biotinylated whereas MCC-B is not.
Orthologs
View orthologs and multiple alignments for MCCB

Proteins

methylcrotonoyl-CoA carboxylase beta chain
Refseq ID NP_567950
Protein GI 18418356
UniProt ID Q9LDD8
mRNA ID NM_119564
Length 587
RefSeq Status REVIEWED
MLRILGRRVVSASKELTSIQQWRIRPGTDSRPDPFRTFRGLQKGFCVGILPDGVDRNSEAFSSNSIAMEGILSELRSHIKKVLAGGGEEAVKRNRSRNKLLPRERIDRLLDPGSSFLELSQLAGHELYEEPLPSGGIITGIGPIHGRICMFMANDPTVKGGTYYPITIKKHLRAQEIAARCRLPCIYLVDSGGAYLPKQAEVFPDKENFGRVFYNESVMSSDGIPQIAIVLGSCTAGGAYIPAMADESVMVKGNGTIFLAGPPLVKAATGEEVSAEDLGGATVHCTVSGVSDYFAQDELHGLAIGRNIVKNLHMAAKQGMEGTFGSKNLVYKEPLYDINELRSIAPVDHKQQFDVRSIIARIVDGSEFDEFKKQYGTTLVTGFARIYGQTVGIIGNNGILFNESALKGAHFIELCSQRKIPLVFLQNITGFMVGSRAEANGIAKAGAKMVMAVSCAKVPKITIITGASFGAGNYAMCGRAYSPDFMFIWPNARIGIMGGAQAAGVLTQIERATKKRQGIKWTEEEEEAFKKKTVDAYEREANPYYSTARLWDDGVIDPCDTRKVLGLCLSAALNRPLEDTRFGVFRM

Gene Information

Entrez Gene ID
829549
Gene Name
methylcrotonoyl-CoA carboxylase beta chain
Gene Symbol
MCCB
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:TAIR C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0050897 IDA:TAIR F cobalt ion binding
GO:0004485 IEA:UniProtKB-EC F methylcrotonoyl-CoA carboxylase activity
GO:0008270 IDA:TAIR F zinc ion binding
GO:0006552 IDA:TAIR P leucine catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath_M00036 Leucine degradation, leucine => acetoacetate + acetyl-CoA
ath01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
6254406 Biotin transport and metabolism
6253683 Branched-chain amino acid catabolism

Domain Information

InterPro Annotations

Accession Description
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR000022 Carboxyl transferase
IPR029045 ClpP/crotonase-like domain

UniProt Annotations

Entry Information

Gene Name
methylcrotonoyl-CoA carboxylase beta chain
Protein Entry
MCCB_ARATH
UniProt ID
Q9LDD8
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + 3-methylcrotonoyl-CoA + HCO(3)(-) = ADP + phosphate + 3-methylglutaconyl-CoA.
Function Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000250}.
Miscellaneous Temporal and spatial accumulation of the alpha and beta subunits during development at approximately equal molar ratios.
Pathway Amino-acid degradation; L-leucine degradation; (S)-3- hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
Sequence Caution Sequence=CAA17569.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA19885.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB80120.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the AccD/PCCB family. {ECO:0000305}.
Similarity Contains 1 carboxyltransferase domain. {ECO:0000305}.
Subcellular Location Mitochondrion matrix.
Subunit Probably a heterodimer composed of biotin-containing alpha subunits and beta subunits. {ECO:0000250}.
Tissue Specificity In roots, cotyledons, leaves, flowers, ovaries, siliques and embryos.

Identical and Related Proteins

Unique RefSeq proteins for LMP010617 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18418356 RefSeq NP_567950 587 methylcrotonoyl-CoA carboxylase beta chain

Identical Sequences to LMP010617 proteins

Reference Database Accession Length Protein Name
GI:18418356 GenBank AAF35258.1 587 3-methylcrotonyl-CoA carboxylase non-biotinylated subunit [Arabidopsis thaliana]
GI:18418356 GenBank AAF35259.1 587 3-methylcrotonyl-CoA carboxylase nonbiotinylated subunit [Arabidopsis thaliana]
GI:18418356 GenBank AAN15703.1 587 Unknown protein [Arabidopsis thaliana]
GI:18418356 GenBank AEE86312.1 587 methylcrotonoyl-CoA carboxylase beta chain [Arabidopsis thaliana]
GI:18418356 SwissProt Q9LDD8.1 587 RecName: Full=Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Short=MCCase subunit beta; AltName: Full=3-methylcrotonyl-CoA carboxylase 2; AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010617 proteins

Reference Database Accession Length Protein Name
GI:18418356 EMBL CAA17569.1 630 putative protein [Arabidopsis thaliana]
GI:18418356 EMBL CAB80120.1 630 putative protein [Arabidopsis thaliana]
GI:18418356 GenBank AAK62371.1 587 Unknown protein [Arabidopsis thaliana]
GI:18418356 GenBank EFH45438.1 626 hypothetical protein ARALYDRAFT_328341 [Arabidopsis lyrata subsp. lyrata]
GI:18418356 PIR - 630 hypothetical protein F28A23.210 - Arabidopsis thaliana [Arabidopsis thaliana]
GI:18418356 RefSeq XP_010432478.1 588 PREDICTED: LOW QUALITY PROTEIN: methylcrotonoyl-CoA carboxylase beta chain, mitochondrial-like [Camelina sativa]